7YSH
 
 | | Cryo-EM Structure of FGF23-FGFR1c-aKlotho-HS Quaternary Complex | | Descriptor: | 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, COPPER (II) ION, Fibroblast growth factor 23, ... | | Authors: | Mohammadi, M, Chen, L. | | Deposit date: | 2022-08-12 | | Release date: | 2023-04-19 | | Last modified: | 2023-07-05 | | Method: | ELECTRON MICROSCOPY (2.74 Å) | | Cite: | Structural basis for FGF hormone signalling.
Nature, 618, 2023
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7XK2
 | | Cryo-EM Structure of Human Niacin Receptor HCA2-Gi protein complex | | Descriptor: | 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Yang, Y, Kang, H.J, Gao, R.G, Wang, J.J, Han, G.W, DiBerto, J.F, Wu, L.J, Tong, J.H, Qu, L, Wu, Y.R, Pileski, R, Li, X.M, Zhang, X.C, Zhao, S.W, Kenakin, T, Wang, Q, Stevens, R.C, Peng, W, Roth, B.L, Rao, Z.H, Liu, Z.J. | | Deposit date: | 2022-04-19 | | Release date: | 2023-02-22 | | Last modified: | 2023-12-06 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural insights into the human niacin receptor HCA2-G i signalling complex.
Nat Commun, 14, 2023
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8HKH
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8JB4
 | | lipopolysaccharide-binding domain-LBDB | | Descriptor: | Antilipopolysaccharide factor D | | Authors: | Huang, J, Qin, Z. | | Deposit date: | 2023-05-08 | | Release date: | 2024-03-13 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Machine learning and genetic algorithm-guided directed evolution for the development of small-molecule antibiotics originating from antimicrobial peptides
To Be Published
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8K37
 | | Structure of the bacteriophage lambda neck | | Descriptor: | Head-tail connector protein FII, Tail tube protein, Tail tube terminator protein | | Authors: | Xiao, H, Tan, L, Cheng, L.P, Liu, H.R. | | Deposit date: | 2023-07-14 | | Release date: | 2023-11-15 | | Last modified: | 2024-01-17 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structure of the siphophage neck-Tail complex suggests that conserved tail tip proteins facilitate receptor binding and tail assembly.
Plos Biol., 21, 2023
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8K38
 | | The structure of bacteriophage lambda portal-adaptor | | Descriptor: | Head completion protein, Portal protein B | | Authors: | Xiao, H, Tan, L, Cheng, L.P, Liu, H.R. | | Deposit date: | 2023-07-14 | | Release date: | 2023-11-15 | | Last modified: | 2024-01-17 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structure of the siphophage neck-Tail complex suggests that conserved tail tip proteins facilitate receptor binding and tail assembly.
Plos Biol., 21, 2023
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8K39
 | | Structure of the bacteriophage lambda portal vertex | | Descriptor: | Major capsid protein, Portal protein B | | Authors: | Xiao, H, Tan, L, Cheng, L.P, Liu, H.R. | | Deposit date: | 2023-07-14 | | Release date: | 2023-11-15 | | Last modified: | 2024-01-17 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structure of the siphophage neck-Tail complex suggests that conserved tail tip proteins facilitate receptor binding and tail assembly.
Plos Biol., 21, 2023
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8K36
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8K35
 | | Structure of the bacteriophage lambda tail tip complex | | Descriptor: | IRON/SULFUR CLUSTER, Tail tip assembly protein I, Tail tip protein L, ... | | Authors: | Xiao, H, Tan, L, Cheng, L.P, Liu, H.R. | | Deposit date: | 2023-07-14 | | Release date: | 2023-11-15 | | Last modified: | 2024-01-17 | | Method: | ELECTRON MICROSCOPY (3.44 Å) | | Cite: | Structure of the siphophage neck-Tail complex suggests that conserved tail tip proteins facilitate receptor binding and tail assembly.
Plos Biol., 21, 2023
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8IDN
 | | Cryo-EM structure of RBD/E77-Fab complex | | Descriptor: | E77 Fab heavy chain, E77 Fab light chain, Spike protein S1, ... | | Authors: | Lu, D.F, Zhang, Z.C. | | Deposit date: | 2023-02-13 | | Release date: | 2023-06-21 | | Last modified: | 2023-08-16 | | Method: | ELECTRON MICROSCOPY (3.35 Å) | | Cite: | The structure of the RBD-E77 Fab complex reveals neutralization and immune escape of SARS-CoV-2.
Acta Crystallogr D Struct Biol, 79, 2023
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8KGS
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8KGL
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8KGQ
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8KGR
 | | Structure of African swine fever virus topoisomerase II in complex with dsDNA | | Descriptor: | DNA (32-MER), DNA (33-MER), DNA topoisomerase 2, ... | | Authors: | Cong, J, Xin, U, Li, X, Chen, Y. | | Deposit date: | 2023-08-19 | | Release date: | 2024-04-03 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structure of African swine fever virus topoisomerase II in complex with dsDNA
To Be Published
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8KGM
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8KGN
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8HW4
 | | Cryo-EM structure of dehydroepiandrosterone sulfate-bound human ABC transporter ABCC3 in nanodiscs | | Descriptor: | 17-oxoandrost-5-en-3beta-yl hydrogen sulfate, ATP-binding cassette sub-family C member 3 | | Authors: | Wang, J, Wang, F.F, Chen, Y.X, Zhou, C.Z. | | Deposit date: | 2022-12-28 | | Release date: | 2023-06-07 | | Last modified: | 2023-10-11 | | Method: | ELECTRON MICROSCOPY (3.52 Å) | | Cite: | Placing steroid hormones within the human ABCC3 transporter reveals a compatible amphiphilic substrate-binding pocket.
Embo J., 42, 2023
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8HVH
 | | Cryo-EM structure of ABC transporter ABCC3 | | Descriptor: | ATP-binding cassette sub-family C member 3 | | Authors: | Wang, J, Wang, F.F, Chen, Y.X, Zhou, C.Z. | | Deposit date: | 2022-12-26 | | Release date: | 2023-06-07 | | Last modified: | 2023-10-11 | | Method: | ELECTRON MICROSCOPY (3.07 Å) | | Cite: | Placing steroid hormones within the human ABCC3 transporter reveals a compatible amphiphilic substrate-binding pocket.
Embo J., 42, 2023
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8HW2
 | | Cryo-EM structure of beta-estradiol 17-(beta-D-glucuronide)-bound human ABC transporter ABCC3 in nanodiscs | | Descriptor: | ATP-binding cassette sub-family C member 3, Estradiol-17beta-glucuronide | | Authors: | Wang, J, Wang, F.F, Chen, Y.X, Zhou, C.Z. | | Deposit date: | 2022-12-28 | | Release date: | 2023-06-07 | | Last modified: | 2023-10-11 | | Method: | ELECTRON MICROSCOPY (3.65 Å) | | Cite: | Placing steroid hormones within the human ABCC3 transporter reveals a compatible amphiphilic substrate-binding pocket.
Embo J., 42, 2023
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7BRO
 | | Crystal structure of the 2019-nCoV main protease | | Descriptor: | 3C-like proteinase | | Authors: | Fu, L.F. | | Deposit date: | 2020-03-29 | | Release date: | 2020-05-13 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease.
Nat Commun, 11, 2020
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7C6S
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7C6U
 | | Crystal structure of SARS-CoV-2 complexed with GC376 | | Descriptor: | (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase | | Authors: | Fu, L, Feng, Y, Qi, J, Gao, F.G. | | Deposit date: | 2020-05-22 | | Release date: | 2020-09-02 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease.
Nat Commun, 11, 2020
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7D65
 | | Cryo-EM Structure of human CALHM5 in the presence of Ca2+ | | Descriptor: | 1,2-DIOCTANOYL-SN-GLYCERO-3-PHOSPHATE, Calcium homeostasis modulator protein 5 | | Authors: | Liu, J, Guan, F.H, Wu, J, Wan, F.T, Lei, M, Ye, S. | | Deposit date: | 2020-09-29 | | Release date: | 2020-12-23 | | Method: | ELECTRON MICROSCOPY (2.94 Å) | | Cite: | Cryo-EM structures of human calcium homeostasis modulator 5.
Cell Discov, 6, 2020
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7D61
 | | Cryo-EM Structure of human CALHM5 in the presence of EDTA | | Descriptor: | 1,2-DIOCTANOYL-SN-GLYCERO-3-PHOSPHATE, Calcium homeostasis modulator protein 5 | | Authors: | Liu, J, Guan, F.H, Wu, J, Wan, F.T, Lei, M, Ye, S. | | Deposit date: | 2020-09-28 | | Release date: | 2020-12-23 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Cryo-EM structures of human calcium homeostasis modulator 5.
Cell Discov, 6, 2020
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7D1M
 | | CRYSTAL STRUCTURE OF THE SARS-CoV-2 MAIN PROTEASE COMPLEXED WITH GC376 | | Descriptor: | (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase, DIMETHYL SULFOXIDE | | Authors: | Fu, L.F, Gilski, M, Shabalin, I, Gao, G.F, Qi, J.X. | | Deposit date: | 2020-09-14 | | Release date: | 2020-10-28 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease.
Nat Commun, 11, 2020
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