8Q00
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![BU of 8q00 by Molmil](/molmil-images/mine/8q00) | TssM-Ub-PA complex - A USP-like DUB from B. pseudomallei (193-430) reacted with Ub-PA | Descriptor: | 1,2-ETHANEDIOL, CITRATE ANION, Polyubiquitin-B, ... | Authors: | Uthoff, M, Hermanns, T, Hofmann, K, Baumann, U. | Deposit date: | 2023-07-27 | Release date: | 2023-12-13 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | The structural basis for deubiquitination by the fingerless USP-type effector TssM. Life Sci Alliance, 7, 2024
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6TJ9
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![BU of 6tj9 by Molmil](/molmil-images/mine/6tj9) | Escherichia coli transketolase in complex with cofactor analog 2'-methoxythiamine and substrate xylulose 5-phosphate | Descriptor: | 1,2-ETHANEDIOL, 2-[3-[(4-azanyl-2-methoxy-pyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate, 5-O-phosphono-D-xylulose, ... | Authors: | Rabe von Pappenheim, F, Tittmann, K. | Deposit date: | 2019-11-25 | Release date: | 2020-07-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (0.95 Å) | Cite: | Structural basis for antibiotic action of the B 1 antivitamin 2'-methoxy-thiamine. Nat.Chem.Biol., 16, 2020
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6TJ8
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![BU of 6tj8 by Molmil](/molmil-images/mine/6tj8) | Escherichia coli transketolase in complex with cofactor analog 2'-methoxythiamine diphosphate | Descriptor: | 1,2-ETHANEDIOL, 2-[3-[(4-azanyl-2-methoxy-pyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate, CALCIUM ION, ... | Authors: | Rabe von Pappenheim, F, Tittmann, K. | Deposit date: | 2019-11-25 | Release date: | 2020-07-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (0.921 Å) | Cite: | Structural basis for antibiotic action of the B 1 antivitamin 2'-methoxy-thiamine. Nat.Chem.Biol., 16, 2020
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5NPA
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![BU of 5npa by Molmil](/molmil-images/mine/5npa) | Solution structure of Drosophila melanogaster Loquacious dsRBD2 | Descriptor: | Loquacious | Authors: | Tants, J.-N, Fesser, S, Kern, T, Stehle, R, Geerlof, A, Wunderlich, C, Boettcher, R, Kunzelmann, S, Lange, O, Kreutz, C, Foerstemann, K, Sattler, M. | Deposit date: | 2017-04-16 | Release date: | 2017-10-04 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Molecular basis for asymmetry sensing of siRNAs by the Drosophila Loqs-PD/Dcr-2 complex in RNA interference. Nucleic Acids Res., 45, 2017
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5NPG
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![BU of 5npg by Molmil](/molmil-images/mine/5npg) | Solution structure of Drosophila melanogaster Loquacious dsRBD1 | Descriptor: | Loquacious, isoform F | Authors: | Tants, J.-N, Fesser, S, Kern, T, Stehle, R, Geerlof, A, Wunderlich, C, Hartlmuller, C, Boettcher, R, Kunzelmann, S, Lange, O, Kreutz, C, Foerstemann, K, Sattler, M. | Deposit date: | 2017-04-16 | Release date: | 2017-10-04 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Molecular basis for asymmetry sensing of siRNAs by the Drosophila Loqs-PD/Dcr-2 complex in RNA interference. Nucleic Acids Res., 45, 2017
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6HA3
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![BU of 6ha3 by Molmil](/molmil-images/mine/6ha3) | Human transketolase variant E160Q in covalent complex with donor ketose D-fructose-6-phosphate | Descriptor: | 1,2-ETHANEDIOL, 2-C-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium-2-yl}-6-O-phosphono-D-glucitol, CALCIUM ION, ... | Authors: | Dai, S, Sautner, V, Tittmann, K. | Deposit date: | 2018-08-07 | Release date: | 2019-08-21 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.08 Å) | Cite: | Low-barrier hydrogen bonds in enzyme cooperativity. Nature, 573, 2019
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6HAF
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![BU of 6haf by Molmil](/molmil-images/mine/6haf) | Pyruvate oxidase variant E59Q from L. plantarum in complex with phosphate | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, MAGNESIUM ION, ... | Authors: | Funk, L.M, Sautner, V, Tittmann, K. | Deposit date: | 2018-08-07 | Release date: | 2019-08-21 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Low-barrier hydrogen bonds in enzyme cooperativity. Nature, 573, 2019
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3ZNX
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![BU of 3znx by Molmil](/molmil-images/mine/3znx) | Crystal structure of the OTU domain of OTULIN D336A mutant | Descriptor: | CALCIUM ION, CHLORIDE ION, GLYCEROL, ... | Authors: | Keusekotten, K, Elliott, P.R, Glockner, L, Kulathu, Y, Wauer, T, Krappmann, D, Hofmann, K, Komander, D. | Deposit date: | 2013-02-18 | Release date: | 2013-06-26 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Otulin Antagonizes Lubac Signaling by Specifically Hydrolyzing met1-Linked Polyubiquitin. Cell(Cambridge,Mass.), 153, 2013
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6HAD
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![BU of 6had by Molmil](/molmil-images/mine/6had) | Human transketolase variant E160Q | Descriptor: | CALCIUM ION, MAGNESIUM ION, SODIUM ION, ... | Authors: | Dai, S, Sautner, V, Tittmann, K. | Deposit date: | 2018-08-07 | Release date: | 2019-08-21 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.04 Å) | Cite: | Low-barrier hydrogen bonds in enzyme cooperativity. Nature, 573, 2019
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3ZNZ
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![BU of 3znz by Molmil](/molmil-images/mine/3znz) | Crystal structure of OTULIN OTU domain (C129A) in complex with Met1- di ubiquitin | Descriptor: | POLYUBIQUITIN-C, PROTEIN FAM105B, SULFATE ION | Authors: | Keusekotten, K, Elliott, P.R, Glockner, L, Kulathu, Y, Wauer, T, Krappmann, D, Hofmann, K, Komander, D. | Deposit date: | 2013-02-18 | Release date: | 2013-06-26 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Otulin Antagonizes Lubac Signaling by Specifically Hydrolyzing met1-Linked Polyubiquitin. Cell(Cambridge,Mass.), 153, 2013
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3ZNV
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![BU of 3znv by Molmil](/molmil-images/mine/3znv) | Crystal structure of the OTU domain of OTULIN at 1.3 Angstroms. | Descriptor: | CALCIUM ION, CHLORIDE ION, GLYCEROL, ... | Authors: | Keusekotten, K, Elliott, P.R, Glockner, L, Kulathu, Y, Wauer, T, Krappmann, D, Hofmann, K, Komander, D. | Deposit date: | 2013-02-18 | Release date: | 2013-06-26 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Otulin Antagonizes Lubac Signaling by Specifically Hydrolyzing met1-Linked Polyubiquitin. Cell(Cambridge,Mass.), 153, 2013
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8ADD
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![BU of 8add by Molmil](/molmil-images/mine/8add) | Viral tegument-like DUBs | Descriptor: | ATP-dependent DNA helicase | Authors: | Erven, I, Abraham, E.T, Hermanns, T, Hofmann, K, Baumann, U. | Deposit date: | 2022-07-08 | Release date: | 2023-02-15 | Last modified: | 2024-09-04 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A widely distributed family of eukaryotic and bacterial deubiquitinases related to herpesviral large tegument proteins. Nat Commun, 13, 2022
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1MI1
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![BU of 1mi1 by Molmil](/molmil-images/mine/1mi1) | Crystal Structure of the PH-BEACH Domain of Human Neurobeachin | Descriptor: | Neurobeachin | Authors: | Jogl, G, Shen, Y, Gebauer, D, Li, J, Wiegmann, K, Kashkar, H, Kroenke, M, Tong, L, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2002-08-21 | Release date: | 2002-09-27 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal structure of the BEACH domain reveals an unusual fold and extensive association with a novel PH domain. EMBO J., 21, 2002
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1E7N
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![BU of 1e7n by Molmil](/molmil-images/mine/1e7n) | The N-terminal domain of beta-B2-crystallin resembles the putative ancestral homodimer | Descriptor: | BETA-CRYSTALLIN B2 | Authors: | Clout, N.J, Basak, A, Wieligmann, K, Bateman, O.A, Jaenicke, R, Slingsby, C. | Deposit date: | 2000-08-31 | Release date: | 2000-10-05 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | The N-Terminal Domain of Betab2-Crystallin Resembles the Putative Ancestral Homodimer. J.Mol.Biol., 304, 2000
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1S2H
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![BU of 1s2h by Molmil](/molmil-images/mine/1s2h) | The Mad2 spindle checkpoint protein possesses two distinct natively folded states | Descriptor: | Mitotic spindle assembly checkpoint protein MAD2A | Authors: | Luo, X, Tang, Z, Xia, G, Wassmann, K, Matsumoto, T, Rizo, J, Yu, H. | Deposit date: | 2004-01-08 | Release date: | 2004-03-30 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | The Mad2 spindle checkpoint protein has two distinct natively folded states. Nat.Struct.Mol.Biol., 11, 2004
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6EI1
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![BU of 6ei1 by Molmil](/molmil-images/mine/6ei1) | Crystal structure of the covalent complex between deubiquitinase ZUFSP (ZUP1) and Ubiquitin-PA | Descriptor: | GLYCEROL, MALONATE ION, Polyubiquitin-B, ... | Authors: | Pichlo, C, Baumann, U, Hofmann, K, Hermanns, T. | Deposit date: | 2017-09-16 | Release date: | 2018-03-07 | Last modified: | 2019-10-16 | Method: | X-RAY DIFFRACTION (1.732 Å) | Cite: | A family of unconventional deubiquitinases with modular chain specificity determinants. Nat Commun, 9, 2018
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7OIY
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![BU of 7oiy by Molmil](/molmil-images/mine/7oiy) | Crystal structure of the ZUFSP family member Mug105 | Descriptor: | SODIUM ION, Ubiquitin carboxyl-terminal hydrolase mug105 | Authors: | Pichlo, C, Hermanns, T, Hofmann, K, Baumann, U. | Deposit date: | 2021-05-12 | Release date: | 2022-02-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | A structural basis for the diverse linkage specificities within the ZUFSP deubiquitinase family. Nat Commun, 13, 2022
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7OJE
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![BU of 7oje by Molmil](/molmil-images/mine/7oje) | Crystal structure of the covalent complex between Tribolium castaneum deubiquitinase ZUP and Ubiquitin-PA | Descriptor: | 1,2-ETHANEDIOL, CITRIC ACID, Lys-63-specific deubiquitinase ZUFSP, ... | Authors: | Pichlo, C, Hermanns, T, Hofmann, K, Baumann, U. | Deposit date: | 2021-05-14 | Release date: | 2022-02-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | A structural basis for the diverse linkage specificities within the ZUFSP deubiquitinase family. Nat Commun, 13, 2022
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2QC7
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![BU of 2qc7 by Molmil](/molmil-images/mine/2qc7) | Crystal structure of the protein-disulfide isomerase related chaperone ERp29 | Descriptor: | Endoplasmic reticulum protein ERp29 | Authors: | Barak, N.N, Sevvana, M, Neumann, P, Malesevic, M, Naumann, K, Fischer, G, Sheldrick, G.M, Stubbs, M.T, Ferrari, D.M. | Deposit date: | 2007-06-19 | Release date: | 2008-06-24 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal structure and functional analysis of the protein disulfide isomerase-related protein ERp29. J.Mol.Biol., 385, 2009
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2R8P
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![BU of 2r8p by Molmil](/molmil-images/mine/2r8p) | Transketolase from E. coli in complex with substrate D-fructose-6-phosphate | Descriptor: | 1,2-ETHANEDIOL, 2-C-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium-2-yl}-6-O-phosphono-D-glucitol, CALCIUM ION, ... | Authors: | Wille, G, Asztalos, P, Weiss, M.S, Tittmann, K. | Deposit date: | 2007-09-11 | Release date: | 2007-12-11 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Strain and near attack conformers in enzymic thiamin catalysis: X-ray crystallographic snapshots of bacterial transketolase in covalent complex with donor ketoses xylulose 5-phosphate and fructose 6-phosphate, and in noncovalent complex with acceptor aldose ribose 5-phosphate. Biochemistry, 46, 2007
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7ZB7
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![BU of 7zb7 by Molmil](/molmil-images/mine/7zb7) | Crystal Structure of SARS-CoV-2 Main Protease (Mpro) variant Y54F at 1.63 A resolution | Descriptor: | 3C-like proteinase nsp5, DIMETHYL SULFOXIDE, GLYCEROL | Authors: | Paknia, E, Rabe von Pappenheim, F, Funk, L.-M, Tittmann, K, Chari, A. | Deposit date: | 2022-03-23 | Release date: | 2022-06-01 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | Multiple redox switches of the SARS-CoV-2 main protease in vitro provide opportunities for drug design. Nat Commun, 15, 2024
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7ZB6
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![BU of 7zb6 by Molmil](/molmil-images/mine/7zb6) | Crystal Structure of SARS-CoV-2 Main Protease (Mpro) variant C44S at 2.12 A resolution | Descriptor: | 3C-like proteinase nsp5, DIMETHYL SULFOXIDE | Authors: | Paknia, E, Rabe von Pappenheim, F, Funk, L.-M, Tittmann, K, Chari, A. | Deposit date: | 2022-03-23 | Release date: | 2022-06-01 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | Multiple redox switches of the SARS-CoV-2 main protease in vitro provide opportunities for drug design. Nat Commun, 15, 2024
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7ZB8
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![BU of 7zb8 by Molmil](/molmil-images/mine/7zb8) | Crystal Structure of SARS-CoV-2 Main Protease (Mpro) variant K61A at 2.48 A resolution | Descriptor: | 3C-like proteinase nsp5, DIMETHYL SULFOXIDE | Authors: | Paknia, E, Rabe von Pappenheim, F, Funk, L.-M, Tittmann, K, Chari, A. | Deposit date: | 2022-03-23 | Release date: | 2022-06-01 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Multiple redox switches of the SARS-CoV-2 main protease in vitro provide opportunities for drug design. Nat Commun, 15, 2024
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2R5N
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![BU of 2r5n by Molmil](/molmil-images/mine/2r5n) | Crystal structure of transketolase from Escherichia coli in noncovalent complex with acceptor aldose ribose 5-phosphate | Descriptor: | 1,2-ETHANEDIOL, 5-O-phosphono-beta-D-ribofuranose, CALCIUM ION, ... | Authors: | Parthier, C, Asztalos, P, Wille, G, Tittmann, K. | Deposit date: | 2007-09-04 | Release date: | 2007-11-06 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Strain and Near Attack Conformers in Enzymic Thiamin Catalysis: X-ray Crystallographic Snapshots of Bacterial Transketolase in Covalent Complex with Donor Ketoses Xylulose 5-phosphate and Fructose 6-phosphate, and in Noncovalent Complex with Acceptor Aldose Ribose 5-phosphate. Biochemistry, 46, 2007
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2R8O
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![BU of 2r8o by Molmil](/molmil-images/mine/2r8o) | Transketolase from E. coli in complex with substrate D-xylulose-5-phosphate | Descriptor: | 1,2-ETHANEDIOL, 2-C-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thia zol-3-ium-2-yl}-5-O-phosphono-D-xylitol, CALCIUM ION, ... | Authors: | Wille, G, Asztalos, P, Weiss, M.S, Tittmann, K. | Deposit date: | 2007-09-11 | Release date: | 2007-12-11 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Strain and near attack conformers in enzymic thiamin catalysis: X-ray crystallographic snapshots of bacterial transketolase in covalent complex with donor ketoses xylulose 5-phosphate and fructose 6-phosphate, and in noncovalent complex with acceptor aldose ribose 5-phosphate. Biochemistry, 46, 2007
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