7ZB7

Crystal Structure of SARS-CoV-2 Main Protease (Mpro) variant Y54F at 1.63 A resolution

Summary for 7ZB7

Entry DOI	10.2210/pdb7zb7/pdb
Descriptor	3C-like proteinase nsp5, DIMETHYL SULFOXIDE, GLYCEROL, ... (4 entities in total)
Functional Keywords	sars-cov-2, mpro, hydrolase
Biological source	Severe acute respiratory syndrome coronavirus 2
Total number of polymer chains	1
Total formula weight	34214.17
Authors	Paknia, E.,Rabe von Pappenheim, F.,Funk, L.-M.,Tittmann, K.,Chari, A. (deposition date: 2022-03-23, release date: 2022-06-01, Last modification date: 2024-01-31)
Primary citation	Funk, L.M.,Poschmann, G.,Rabe von Pappenheim, F.,Chari, A.,Stegmann, K.M.,Dickmanns, A.,Wensien, M.,Eulig, N.,Paknia, E.,Heyne, G.,Penka, E.,Pearson, A.R.,Berndt, C.,Fritz, T.,Bazzi, S.,Uranga, J.,Mata, R.A.,Dobbelstein, M.,Hilgenfeld, R.,Curth, U.,Tittmann, K. Multiple redox switches of the SARS-CoV-2 main protease in vitro provide opportunities for drug design. Nat Commun, 15:411-411, 2024 Cited by PubMed: 38195625 DOI: 10.1038/s41467-023-44621-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.63 Å)

Structure validation