6TJ9

Escherichia coli transketolase in complex with cofactor analog 2'-methoxythiamine and substrate xylulose 5-phosphate

Summary for 6TJ9

Entry DOI	10.2210/pdb6tj9/pdb
Descriptor	Transketolase 1, 5-O-phosphono-D-xylulose, 2-[3-[(4-azanyl-2-methoxy-pyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate, ... (7 entities in total)
Functional Keywords	thiamin diphosphate, enzyme catalysis, pentose phosphate pathway, transferase
Biological source	Escherichia coli (strain K12)
Total number of polymer chains	2
Total formula weight	149325.77
Authors	Rabe von Pappenheim, F.,Tittmann, K. (deposition date: 2019-11-25, release date: 2020-07-08, Last modification date: 2024-01-24)
Primary citation	Rabe von Pappenheim, F.,Aldeghi, M.,Shome, B.,Begley, T.,de Groot, B.L.,Tittmann, K. Structural basis for antibiotic action of the B 1 antivitamin 2'-methoxy-thiamine. Nat.Chem.Biol., 16:1237-1245, 2020 Cited by PubMed: 32839604 DOI: 10.1038/s41589-020-0628-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (0.95 Å)

Structure validation