7NAL
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![BU of 7nal by Molmil](/molmil-images/mine/7nal) | Cryo-EM structure of activated human SARM1 in complex with NMN and 1AD (ARM and SAM domains) | Descriptor: | BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, NAD(+) hydrolase SARM1 | Authors: | Kerry, P.S, Nanson, J.D, Adams, S, Cunnea, K, Bosanac, T, Kobe, B, Hughes, R.O, Ve, T. | Deposit date: | 2021-06-21 | Release date: | 2022-03-23 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules. Mol.Cell, 82, 2022
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6UH8
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![BU of 6uh8 by Molmil](/molmil-images/mine/6uh8) | Crystal structure of DAD2 N242I mutant | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Decreased Apical Dominance 2, GLYCEROL, ... | Authors: | Sharma, P, Hamiaux, C, Snowden, K.C. | Deposit date: | 2019-09-27 | Release date: | 2020-02-26 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Flexibility of the petunia strigolactone receptor DAD2 promotes its interaction with signaling partners. J.Biol.Chem., 295, 2020
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6UH9
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![BU of 6uh9 by Molmil](/molmil-images/mine/6uh9) | Crystal structure of DAD2 D166A mutant | Descriptor: | Decreased Apical Dominance 2, TETRAETHYLENE GLYCOL | Authors: | Sharma, P, Hamiaux, C, Snowden, K.C. | Deposit date: | 2019-09-27 | Release date: | 2020-02-26 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | Flexibility of the petunia strigolactone receptor DAD2 promotes its interaction with signaling partners. J.Biol.Chem., 295, 2020
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6LI3
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![BU of 6li3 by Molmil](/molmil-images/mine/6li3) | cryo-EM structure of GPR52-miniGs-NB35 | Descriptor: | G-protein coupled receptor 52, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Li, M, Wang, N, Xu, F, Wu, J, Lei, M. | Deposit date: | 2019-12-10 | Release date: | 2020-02-26 | Last modified: | 2020-03-18 | Method: | ELECTRON MICROSCOPY (3.32 Å) | Cite: | Structural basis of ligand recognition and self-activation of orphan GPR52. Nature, 579, 2020
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8I2J
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![BU of 8i2j by Molmil](/molmil-images/mine/8i2j) | |
8I27
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![BU of 8i27 by Molmil](/molmil-images/mine/8i27) | |
8I4I
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![BU of 8i4i by Molmil](/molmil-images/mine/8i4i) | |
8I2M
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8I1Y
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![BU of 8i1y by Molmil](/molmil-images/mine/8i1y) | The structure of E. coli TrpRS bound with a chemical fragment | Descriptor: | 5-ethanoylthiophene-2-carbonitrile, SULFATE ION, TRYPTOPHANYL-5'AMP, ... | Authors: | Xiang, M, Zhou, H. | Deposit date: | 2023-01-13 | Release date: | 2023-04-12 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | An asymmetric structure of bacterial TrpRS supports the half-of-the-sites catalytic mechanism and facilitates antimicrobial screening. Nucleic Acids Res., 51, 2023
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8I2A
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8I2L
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8I1W
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8I1Z
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![BU of 8i1z by Molmil](/molmil-images/mine/8i1z) | E. coli tryptophanyl-tRNA synthetase bound with a chemical fragment | Descriptor: | 1-(2,3-dihydro-1-benzofuran-5-yl)ethanone, SULFATE ION, TRYPTOPHANYL-5'AMP, ... | Authors: | Xiang, M, Zhou, H. | Deposit date: | 2023-01-13 | Release date: | 2023-04-12 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | An asymmetric structure of bacterial TrpRS supports the half-of-the-sites catalytic mechanism and facilitates antimicrobial screening. Nucleic Acids Res., 51, 2023
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8I2C
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5ZNK
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![BU of 5znk by Molmil](/molmil-images/mine/5znk) | Crystal structure of a bacterial ProRS with ligands | Descriptor: | 7-chloro-6-fluoro-3-{2-oxo-3-[(2S)-piperidin-2-yl]propyl}quinazolin-4(3H)-one, GLYCEROL, MAGNESIUM ION, ... | Authors: | Cheng, B, Yu, Y, Zhou, H. | Deposit date: | 2018-04-09 | Release date: | 2019-05-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Structure-Guided Design of Halofuginone Derivatives as ATP-Aided Inhibitors Against Bacterial Prolyl-tRNA Synthetase. J.Med.Chem., 65, 2022
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5ZNJ
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![BU of 5znj by Molmil](/molmil-images/mine/5znj) | Crystal structure of a bacterial ProRS with ligands | Descriptor: | 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, GLYCEROL, MAGNESIUM ION, ... | Authors: | Cheng, B, Yu, Y, Zhou, H. | Deposit date: | 2018-04-09 | Release date: | 2019-05-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Structure-Guided Design of Halofuginone Derivatives as ATP-Aided Inhibitors Against Bacterial Prolyl-tRNA Synthetase. J.Med.Chem., 65, 2022
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7KXT
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![BU of 7kxt by Molmil](/molmil-images/mine/7kxt) | Crystal structure of human EED | Descriptor: | 1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-benzimidazol-2-amine, Polycomb protein EED, UNKNOWN ATOM OR ION | Authors: | Zhu, L, Dong, A, Du, D, Liu, Y, Luo, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2020-12-04 | Release date: | 2021-02-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction. J.Med.Chem., 64, 2021
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4R15
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![BU of 4r15 by Molmil](/molmil-images/mine/4r15) | High-resolution crystal structure of Z-DNA in complex with Cr3+ cations | Descriptor: | CHROMIUM ION, DNA (5'-D(*CP*GP*CP*GP*CP*G)-3') | Authors: | Drozdzal, P, Gilski, M, Kierzek, R, Lomozik, L, Jaskolski, M. | Deposit date: | 2014-08-04 | Release date: | 2015-03-04 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (0.97 Å) | Cite: | High-resolution crystal structure of Z-DNA in complex with Cr(3+) cations. J.Biol.Inorg.Chem., 20, 2015
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5EW6
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![BU of 5ew6 by Molmil](/molmil-images/mine/5ew6) | Structure of ligand binding region of uPARAP at pH 7.4 without calcium | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C-type mannose receptor 2, ... | Authors: | Yuan, C, Huang, M. | Deposit date: | 2015-11-20 | Release date: | 2016-08-10 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | Crystal structures of the ligand-binding region of uPARAP: effect of calcium ion binding Biochem.J., 473, 2016
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6AP8
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5E4K
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![BU of 5e4k by Molmil](/molmil-images/mine/5e4k) | Structure of ligand binding region of uPARAP at pH 7.4 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, C-type mannose receptor 2, ... | Authors: | Yuan, C, Huang, M. | Deposit date: | 2015-10-06 | Release date: | 2016-08-10 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.58 Å) | Cite: | Crystal structures of the ligand-binding region of uPARAP: effect of calcium ion binding Biochem.J., 473, 2016
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6AP6
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![BU of 6ap6 by Molmil](/molmil-images/mine/6ap6) | Crystal Structure of DAD2 in complex with tolfenamic acid | Descriptor: | 2-[(3-chloro-2-methylphenyl)amino]benzoic acid, Probable strigolactone esterase DAD2 | Authors: | Hamiaux, C. | Deposit date: | 2017-08-17 | Release date: | 2018-03-21 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Inhibition of strigolactone receptors byN-phenylanthranilic acid derivatives: Structural and functional insights. J. Biol. Chem., 293, 2018
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6AP7
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5XS3
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![BU of 5xs3 by Molmil](/molmil-images/mine/5xs3) | Crystal structure of HLA Class I antigen | Descriptor: | Heavy Chain, Light Chain, P | Authors: | Wei, P.C, Yang, Y, Liu, Z.X, Luo, Z.Q, Tu, W.Y, Han, J.Y, Deng, Y.H, Yin, L. | Deposit date: | 2017-06-12 | Release date: | 2017-09-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Characterization of Autoantigen Presentation by HLA-C*06:02 in Psoriasis J. Invest. Dermatol., 137, 2017
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8GZ4
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![BU of 8gz4 by Molmil](/molmil-images/mine/8gz4) | Crystal structure of MPXV phosphatase | Descriptor: | Dual specificity protein phosphatase H1, PHOSPHATE ION | Authors: | Yang, H.T, Wang, W, Huang, H.J, Ji, X.Y. | Deposit date: | 2022-09-25 | Release date: | 2023-05-17 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.802 Å) | Cite: | Crystal structure of monkeypox H1 phosphatase, an antiviral drug target. Protein Cell, 14, 2023
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