2W2X
| Complex of Rac2 and PLCg2 spPH Domain | Descriptor: | 1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-2, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, ... | Authors: | Opaleye, O, Bunney, T.D, Roe, S.M, Pearl, L.H. | Deposit date: | 2008-11-04 | Release date: | 2009-05-05 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural Insights Into Formation of an Active Signaling Complex between Rac and Phospholipase C Gamma 2. Mol.Cell, 34, 2009
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5B5I
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2QN9
| Glycogen Phosphorylase in complex with N-4-aminobenzoyl-N'-beta-D-glucopyranosyl urea | Descriptor: | Glycogen phosphorylase, muscle form, INOSINIC ACID, ... | Authors: | Chrysina, E.D, Tiraidis, C, Alexacou, K.-M, Zographos, S.E, Leonidas, D.D, Oikonomakos, N.G. | Deposit date: | 2007-07-18 | Release date: | 2008-07-22 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | N-(4-substituted-benzoyl)-N'-(beta-D-glucopyranosyl)ureas, inhibitors of glycogen phosphorylase: synthesis, kinetic and crystallographic evaluation To be Published
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3A5R
| Benzalacetone synthase from Rheum palmatum complexed with 4-coumaroyl-primed monoketide intermediate | Descriptor: | 4'-HYDROXYCINNAMIC ACID, Benzalacetone synthase | Authors: | Morita, H, Kato, R, Abe, I, Sugio, S, Kohno, T. | Deposit date: | 2009-08-10 | Release date: | 2010-01-26 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | A structure-based mechanism for benzalacetone synthase from Rheum palmatum Proc.Natl.Acad.Sci.USA, 107, 2010
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3A5Q
| Benzalacetone synthase from Rheum palmatum | Descriptor: | Benzalacetone synthase | Authors: | Morita, H, Kato, R, Abe, I, Sugio, S, Kohno, T. | Deposit date: | 2009-08-10 | Release date: | 2010-01-26 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A structure-based mechanism for benzalacetone synthase from Rheum palmatum Proc.Natl.Acad.Sci.USA, 107, 2010
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2ZZN
| The complex structure of aTrm5 and tRNACys | Descriptor: | MAGNESIUM ION, RNA (71-MER), S-ADENOSYLMETHIONINE, ... | Authors: | Goto-Ito, S, Ito, T, Yokoyama, S. | Deposit date: | 2009-02-19 | Release date: | 2009-09-15 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Tertiary structure checkpoint at anticodon loop modification in tRNA functional maturation. Nat.Struct.Mol.Biol., 16, 2009
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3A5S
| Benzalacetone synthase (I207L/L208F) | Descriptor: | Benzalacetone synthase | Authors: | Morita, H, Kato, R, Abe, I, Sugio, S, Kohno, T. | Deposit date: | 2009-08-10 | Release date: | 2010-01-26 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A structure-based mechanism for benzalacetone synthase from Rheum palmatum Proc.Natl.Acad.Sci.USA, 107, 2010
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2ZZM
| The complex structure of aTrm5 and tRNALeu | Descriptor: | MAGNESIUM ION, RNA (84-MER), S-ADENOSYLMETHIONINE, ... | Authors: | Goto-Ito, S, Ito, T, Yokoyama, S. | Deposit date: | 2009-02-19 | Release date: | 2009-09-15 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Tertiary structure checkpoint at anticodon loop modification in tRNA functional maturation Nat.Struct.Mol.Biol., 16, 2009
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3SYU
| Re-refined coordinates for pdb entry 1det - ribonuclease T1 carboxymethylated at GLU 58 in complex with 2'GMP | Descriptor: | GUANOSINE-2'-MONOPHOSPHATE, Guanyl-specific ribonuclease T1, SODIUM ION, ... | Authors: | Smart, O.S, Womack, T.O, Bricogne, G. | Deposit date: | 2011-07-18 | Release date: | 2012-03-28 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Exploiting structure similarity in refinement: automated NCS and target-structure restraints in BUSTER. Acta Crystallogr.,Sect.D, 68, 2012
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7XLP
| MEK1 bound to DS03090629 | Descriptor: | (1~{R},3~{S})-3-[[6-[2-chloranyl-4-(4-methylpyrimidin-2-yl)oxy-phenyl]-3-methyl-1~{H}-indazol-4-yl]oxy]cyclohexan-1-amine, CALCIUM ION, DIMETHYL SULFOXIDE, ... | Authors: | Kishikawa, S, Takano, K, Ubukata, O, Hanzawa, H. | Deposit date: | 2022-04-22 | Release date: | 2023-03-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Discovery of a Novel ATP-Competitive MEK Inhibitor DS03090629 that Overcomes Resistance Conferred by BRAF Overexpression in BRAF-Mutated Melanoma. Mol.Cancer Ther., 22, 2023
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7XNC
| MEK1 bound to DS94070624 | Descriptor: | CALCIUM ION, DIMETHYL SULFOXIDE, Dual specificity mitogen-activated protein kinase kinase 1, ... | Authors: | Kishikawa, S, Takano, K, Ubukata, O, Hanzawa, H. | Deposit date: | 2022-04-28 | Release date: | 2023-03-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Discovery of a Novel ATP-Competitive MEK Inhibitor DS03090629 that Overcomes Resistance Conferred by BRAF Overexpression in BRAF-Mutated Melanoma. Mol.Cancer Ther., 22, 2023
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2ZJC
| TNFR1 selectve TNF mutant; R1-6 | Descriptor: | GLYCEROL, Tumor necrosis factor | Authors: | Mukai, Y, Yamagata, Y, Tsutsumi, Y. | Deposit date: | 2008-03-05 | Release date: | 2009-01-20 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure-Function Relationship of Tumor Necrosis Factor (TNF) and Its Receptor Interaction Based on 3D Structural Analysis of a Fully Active TNFR1-Selective TNF Mutant J.Mol.Biol., 385, 2009
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7Y3F
| Structure of the Anabaena PSI-monomer-IsiA supercomplex | Descriptor: | 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, BETA-CAROTENE, ... | Authors: | Nagao, R, Kato, K, Hamaguchi, T, Kawakami, K, Yonekura, K, Shen, J.R. | Deposit date: | 2022-06-10 | Release date: | 2023-03-01 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (2.62 Å) | Cite: | Structure of a monomeric photosystem I core associated with iron-stress-induced-A proteins from Anabaena sp. PCC 7120. Nat Commun, 14, 2023
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2ZPX
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1SAY
| L-ALANINE DEHYDROGENASE COMPLEXED WITH PYRUVATE | Descriptor: | L-ALANINE DEHYDROGENASE, PYRUVIC ACID | Authors: | Baker, P.J, Sawa, Y, Shibata, H, Sedelnikova, S.E, Rice, D.W. | Deposit date: | 1998-06-05 | Release date: | 1999-06-08 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Analysis of the structure and substrate binding of Phormidium lapideum alanine dehydrogenase. Nat.Struct.Biol., 5, 1998
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1PJB
| L-ALANINE DEHYDROGENASE | Descriptor: | L-ALANINE DEHYDROGENASE | Authors: | Baker, P.J, Sawa, Y, Shibata, H, Sedelnikova, S.E, Rice, D.W. | Deposit date: | 1998-06-05 | Release date: | 1999-06-08 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Analysis of the structure and substrate binding of Phormidium lapideum alanine dehydrogenase. Nat.Struct.Biol., 5, 1998
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1PJC
| L-ALANINE DEHYDROGENASE COMPLEXED WITH NAD | Descriptor: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PROTEIN (L-ALANINE DEHYDROGENASE) | Authors: | Baker, P.J, Sawa, Y, Shibata, H, Sedelnikova, S.E, Rice, D.W. | Deposit date: | 1998-06-05 | Release date: | 1999-07-15 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Analysis of the structure and substrate binding of Phormidium lapideum alanine dehydrogenase. Nat.Struct.Biol., 5, 1998
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1KZK
| JE-2147-HIV Protease Complex | Descriptor: | (4R)-3-{(2S,3S)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-phenylbutanoyl}-5,5-dimethyl-N-(2-methylbenzyl)-1,3-thiazolidine-4-carboxamide, 1,2-ETHANEDIOL, CHLORIDE ION, ... | Authors: | Reiling, K.K, Endres, N.F, Dauber, D.S, Craik, C.S, Stroud, R.M. | Deposit date: | 2002-02-06 | Release date: | 2002-04-03 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.09 Å) | Cite: | Anisotropic Dynamics of the JE-2147-HIV Protease Complex:
Drug Resistance and Thermodynamic Binding Mode Examined in a 1.09 A Structure Biochemistry, 41, 2002
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4MT9
| Co-crystal structure of tankyrase 1 with compound 49 | Descriptor: | N-[trans-4-(4-cyanophenoxy)cyclohexyl]-3-[(4-oxo-3,4-dihydroquinazolin-2-yl)sulfanyl]propanamide, Tankyrase-1, ZINC ION | Authors: | Huang, X. | Deposit date: | 2013-09-19 | Release date: | 2013-12-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Development of novel dual binders as potent, selective, and orally bioavailable tankyrase inhibitors. J.Med.Chem., 56, 2013
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4MSG
| Crystal structure of tankyrase 1 with compound 22 | Descriptor: | 3-[(4-oxo-3,4-dihydroquinazolin-2-yl)sulfanyl]-N-[trans-4-(5-phenyl-1,3,4-oxadiazol-2-yl)cyclohexyl]propanamide, Tankyrase-1, ZINC ION | Authors: | Huang, X. | Deposit date: | 2013-09-18 | Release date: | 2013-12-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Development of novel dual binders as potent, selective, and orally bioavailable tankyrase inhibitors. J.Med.Chem., 56, 2013
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1QAS
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1OFV
| FLAVODOXIN FROM ANACYSTIS NIDULANS: REFINEMENT OF TWO FORMS OF THE OXIDIZED PROTEIN | Descriptor: | FLAVIN MONONUCLEOTIDE, FLAVODOXIN | Authors: | Smith, W.W, Pattridge, K.A, Luschinsky, C.L, Ludwig, M.L. | Deposit date: | 1992-06-22 | Release date: | 1994-01-31 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Refined structures of oxidized flavodoxin from Anacystis nidulans. J.Mol.Biol., 294, 1999
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4EN6
| Crystal structure of HA70 (HA3) subcomponent of Clostridium botulinum type C progenitor toxin in complex with alpha 2-3-sialyllactose | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, Hemagglutinin components HA-22/23/53, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-beta-D-glucopyranose | Authors: | Yamashita, S, Yoshida, H, Tonozuka, T, Nishikawa, A, Kamitori, S. | Deposit date: | 2012-04-12 | Release date: | 2012-06-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.56 Å) | Cite: | Carbohydrate recognition mechanism of HA70 from Clostridium botulinum deduced from X-ray structures in complexes with sialylated oligosaccharides Febs Lett., 586, 2012
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1QAT
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4MSK
| Co-crystal structure of tankyrase 1 with compound 34 | Descriptor: | 3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-[4-(5-phenyl-1,3,4-oxadiazol-2-yl)phenyl]propanamide, Tankyrase-1, ZINC ION | Authors: | Huang, X. | Deposit date: | 2013-09-18 | Release date: | 2013-12-25 | Last modified: | 2014-02-05 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Development of novel dual binders as potent, selective, and orally bioavailable tankyrase inhibitors. J.Med.Chem., 56, 2013
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