4MSK

Co-crystal structure of tankyrase 1 with compound 34

Summary for 4MSK

Entry DOI	10.2210/pdb4msk/pdb
Related	4I9I 4MSG
Descriptor	Tankyrase-1, ZINC ION, 3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-[4-(5-phenyl-1,3,4-oxadiazol-2-yl)phenyl]propanamide, ... (4 entities in total)
Functional Keywords	tankyrase, parp, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: O95271
Total number of polymer chains	4
Total formula weight	102176.76
Authors	Huang, X. (deposition date: 2013-09-18, release date: 2013-12-25, Last modification date: 2014-02-05)
Primary citation	Hua, Z.,Bregman, H.,Buchanan, J.L.,Chakka, N.,Guzman-Perez, A.,Gunaydin, H.,Huang, X.,Gu, Y.,Berry, V.,Liu, J.,Teffera, Y.,Huang, L.,Egge, B.,Emkey, R.,Mullady, E.L.,Schneider, S.,Andrews, P.S.,Acquaviva, L.,Dovey, J.,Mishra, A.,Newcomb, J.,Saffran, D.,Serafino, R.,Strathdee, C.A.,Turci, S.M.,Stanton, M.,Wilson, C.,Dimauro, E.F. Development of novel dual binders as potent, selective, and orally bioavailable tankyrase inhibitors. J.Med.Chem., 56:10003-10015, 2013 Cited by PubMed: 24294969 DOI: 10.1021/jm401317z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation