4MSK

Co-crystal structure of tankyrase 1 with compound 34

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003950	molecular_function	NAD+ poly-ADP-ribosyltransferase activity
B	0003950	molecular_function	NAD+ poly-ADP-ribosyltransferase activity
C	0003950	molecular_function	NAD+ poly-ADP-ribosyltransferase activity
D	0003950	molecular_function	NAD+ poly-ADP-ribosyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1401

Chain	Residue
A	CYS1234
A	HIS1237
A	CYS1242
A	CYS1245

---

site_id	AC2
Number of Residues	20
Details	BINDING SITE FOR RESIDUE 2C8 A 1402

Chain	Residue
A	LYS1195
A	GLY1196
A	PHE1197
A	ASP1198
A	HIS1201
A	TYR1203
A	ILE1212
A	TYR1213
A	PHE1214
A	ALA1215
A	LYS1220
A	SER1221
A	TYR1224
A	GLU1291
A	HOH1526
A	HIS1184
A	GLY1185
A	SER1186
A	PHE1188
A	ALA1191

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1401

Chain	Residue
B	CYS1234
B	HIS1237
B	CYS1242
B	CYS1245

---

site_id	AC4
Number of Residues	18
Details	BINDING SITE FOR RESIDUE 2C8 B 1402

Chain	Residue
B	HIS1184
B	GLY1185
B	PHE1188
B	ALA1191
B	GLY1196
B	PHE1197
B	ASP1198
B	HIS1201
B	TYR1203
B	ILE1212
B	TYR1213
B	PHE1214
B	ALA1215
B	LYS1220
B	SER1221
B	TYR1224
B	GLU1291
B	HOH1516

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN C 1401

Chain	Residue
C	HIS1237
C	CYS1242
C	CYS1245

---

site_id	AC6
Number of Residues	17
Details	BINDING SITE FOR RESIDUE 2C8 C 1402

Chain	Residue
C	HIS1184
C	GLY1185
C	PHE1188
C	LYS1195
C	GLY1196
C	PHE1197
C	ASP1198
C	HIS1201
C	TYR1203
C	ILE1212
C	TYR1213
C	PHE1214
C	ALA1215
C	LYS1220
C	SER1221
C	TYR1224
C	GLU1291

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 1401

Chain	Residue
D	CYS1234
D	HIS1237
D	CYS1242
D	CYS1245

---

site_id	AC8
Number of Residues	18
Details	BINDING SITE FOR RESIDUE 2C8 D 1402

Chain	Residue
D	HIS1184
D	GLY1185
D	SER1186
D	PHE1188
D	ALA1191
D	LYS1195
D	GLY1196
D	PHE1197
D	ASP1198
D	HIS1201
D	TYR1203
D	TYR1213
D	PHE1214
D	ALA1215
D	LYS1220
D	SER1221
D	TYR1224
D	GLU1291

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	15
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18436240","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2RF5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UDD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UH2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3UH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DVI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4I9I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4K4E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4K4F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LI6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LI8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MSG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MT9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4N3R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4N4V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OA7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TOR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TOS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4W5S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4W6E","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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