7QN8
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![BU of 7qn8 by Molmil](/molmil-images/mine/7qn8) | Cryo-EM structure of human full-length beta3delta GABA(A)R in complex with histamine and nanobody Nb25 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit beta-3, ... | Authors: | Sente, A, Desai, R, Naydenova, K, Malinauskas, T, Jounaidi, Y, Miehling, J, Zhou, X, Masiulis, S, Hardwick, S.W, Chirgadze, D.Y, Miller, K.W, Aricescu, A.R. | Deposit date: | 2021-12-20 | Release date: | 2022-04-13 | Last modified: | 2022-04-20 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Differential assembly diversifies GABA A receptor structures and signalling. Nature, 604, 2022
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7QN6
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![BU of 7qn6 by Molmil](/molmil-images/mine/7qn6) | Cryo-EM structure of human full-length beta3delta GABA(A)R in complex with nanobody Nb25 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | Authors: | Sente, A, Desai, R, Naydenova, K, Malinauskas, T, Jounaidi, Y, Miehling, J, Zhou, X, Masiulis, S, Hardwick, S.W, Chirgadze, D.Y, Miller, K.W, Aricescu, A.R. | Deposit date: | 2021-12-20 | Release date: | 2022-04-13 | Last modified: | 2022-04-20 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Differential assembly diversifies GABA A receptor structures and signalling. Nature, 604, 2022
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7QN9
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![BU of 7qn9 by Molmil](/molmil-images/mine/7qn9) | Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex with GABA, histamine and nanobody Nb25 in a pre-open/closed state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DECANE, ... | Authors: | Sente, A, Desai, R, Naydenova, K, Malinauskas, T, Jounaidi, Y, Miehling, J, Zhou, X, Masiulis, S, Hardwick, S.W, Chirgadze, D.Y, Miller, K.W, Aricescu, A.R. | Deposit date: | 2021-12-20 | Release date: | 2022-04-13 | Last modified: | 2022-04-20 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Differential assembly diversifies GABA A receptor structures and signalling. Nature, 604, 2022
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6LGV
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![BU of 6lgv by Molmil](/molmil-images/mine/6lgv) | Crystal structure of a cysteine-pair mutant (P10C-S291C) of a bacterial bile acid transporter in an inward-facing state complexed with citrate | Descriptor: | 2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CITRIC ACID, Transporter, ... | Authors: | Wang, X, Lyu, Y, Ji, Y, Sun, Z, Zhou, X. | Deposit date: | 2019-12-06 | Release date: | 2020-12-09 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.847 Å) | Cite: | Substrate binding in the bile acid transporter ASBT Yf from Yersinia frederiksenii. Acta Crystallogr D Struct Biol, 77, 2021
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8GS8
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![BU of 8gs8 by Molmil](/molmil-images/mine/8gs8) | cryo-EM structure of the human respiratory complex II | Descriptor: | (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, FE2/S2 (INORGANIC) CLUSTER, FE3-S4 CLUSTER, ... | Authors: | Du, Z, Zhou, X, Lai, Y, Xu, J, Zhang, Y, Zhou, S, Liu, F, Gao, Y, Gong, H, Rao, Z. | Deposit date: | 2022-09-05 | Release date: | 2023-05-10 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.86 Å) | Cite: | Structure of the human respiratory complex II. Proc.Natl.Acad.Sci.USA, 120, 2023
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4Z0B
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![BU of 4z0b by Molmil](/molmil-images/mine/4z0b) | Crystal Structure of the Fab Fragment of Anti-ofloxacin Antibody and Exploration Its Receptor Binding Site | Descriptor: | PHOSPHATE ION, antibody heavy chain, antibody light chain | Authors: | He, K, Du, X, Sheng, W, Zhou, X, Wang, J, Wang, S. | Deposit date: | 2015-03-26 | Release date: | 2016-04-27 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Crystal Structure of the Fab Fragment of an Anti-ofloxacin Antibody and Exploration of Its Specific Binding. J.Agric.Food Chem., 64, 2016
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7TAK
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![BU of 7tak by Molmil](/molmil-images/mine/7tak) | Structure of a NAT transporter | Descriptor: | GUANINE, Putative membrane protein PurT | Authors: | Weng, J, Zhou, X, Ren, Z, Chen, K, Zhou, M. | Deposit date: | 2021-12-21 | Release date: | 2023-01-25 | Last modified: | 2024-08-07 | Method: | X-RAY DIFFRACTION (2.79828 Å) | Cite: | Insight into the mechanism of H + -coupled nucleobase transport. Proc.Natl.Acad.Sci.USA, 120, 2023
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5GNS
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![BU of 5gns by Molmil](/molmil-images/mine/5gns) | Structures of human Mitofusin 1 provide insight into mitochondrial tethering | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, Mitofusin-1 | Authors: | Qi, Y, Yan, L, Yu, C, Guo, X, Zhou, X, Hu, X, Huang, X, Rao, Z, Lou, Z, Hu, J. | Deposit date: | 2016-07-24 | Release date: | 2016-12-07 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.702 Å) | Cite: | Structures of human Mitofusin 1 provide insight into mitochondrial tethering To Be Published
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5U6I
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![BU of 5u6i by Molmil](/molmil-images/mine/5u6i) | Discovery of MLi-2, an Orally Available and Selective LRRK2 Inhibitor that Reduces Brain Kinase Activity | Descriptor: | 3-[2-(morpholin-4-yl)pyridin-4-yl]-5-[(propan-2-yl)oxy]-1H-indazole, Mitogen-activated protein kinase 1, SULFATE ION | Authors: | Scott, J.D, DeMong, D.E, Fell, M.J, Mirescu, C, Basu, K, Greshock, T.J, Morrow, J.A, Xiao, L, Hruza, A, Harris, J, Tiscia, H.E, Chang, R.K, Embrey, M.W, McCauley, J.A, Li, W, Lin, S, Liu, H, Dai, X, Baptista, M, Agnihotri, G, Columbus, J, Mei, H, Poirier, M, Zhou, X, Lin, Y, Yin, Z, Sanders, J.M, Drolet, R.E, Kern, J.T, Kennedy, M.E, Parker, E.M, Stamford, A.W, Nargund, R, Miller, M.W. | Deposit date: | 2016-12-08 | Release date: | 2017-03-15 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity. J. Med. Chem., 60, 2017
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5H3O
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![BU of 5h3o by Molmil](/molmil-images/mine/5h3o) | Structure of a eukaryotic cyclic nucleotide-gated channel | Descriptor: | CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated cation channel, SODIUM ION | Authors: | Li, M, Zhou, X, Wang, S, Michailidis, I, Gong, Y, Su, D, Li, H, Li, X, Yang, J. | Deposit date: | 2016-10-26 | Release date: | 2017-01-25 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structure of a eukaryotic cyclic-nucleotide-gated channel. Nature, 542, 2017
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5TJB
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![BU of 5tjb by Molmil](/molmil-images/mine/5tjb) | I-II linker of TRPML1 channel at pH 4.5 | Descriptor: | Mucolipin-1 | Authors: | Li, M, Zhang, W.K, Benvin, N.M, Zhou, X, Su, D, Li, H, Wang, S, Michailidis, I.E, Tong, L, Li, X, Yang, J. | Deposit date: | 2016-10-04 | Release date: | 2017-01-25 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis of dual Ca(2+)/pH regulation of the endolysosomal TRPML1 channel. Nat. Struct. Mol. Biol., 24, 2017
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5TJA
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![BU of 5tja by Molmil](/molmil-images/mine/5tja) | I-II linker of TRPML1 channel at pH 6 | Descriptor: | Mucolipin-1 | Authors: | Li, M, Zhang, W.K, Benvin, N.M, Zhou, X, Su, D, Li, H, Wang, S, Michailidis, I.E, Tong, L, Li, X, Yang, J. | Deposit date: | 2016-10-04 | Release date: | 2017-01-25 | Last modified: | 2019-12-18 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis of dual Ca(2+)/pH regulation of the endolysosomal TRPML1 channel. Nat. Struct. Mol. Biol., 24, 2017
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5TJC
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![BU of 5tjc by Molmil](/molmil-images/mine/5tjc) | I-II linker of TRPML1 channel at pH 7.5 | Descriptor: | Mucolipin-1 | Authors: | Li, M, Zhang, W.K, Benvin, N.M, Zhou, X, Su, D, Li, H, Wang, S, Michailidis, I.E, Tong, L, Li, X, Yang, J. | Deposit date: | 2016-10-04 | Release date: | 2017-01-25 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis of dual Ca(2+)/pH regulation of the endolysosomal TRPML1 channel. Nat. Struct. Mol. Biol., 24, 2017
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2HPL
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![BU of 2hpl by Molmil](/molmil-images/mine/2hpl) | Crystal structure of the mouse p97/PNGase complex | Descriptor: | C-terminal of mouse p97/VCP, PNGase | Authors: | Zhao, G, Zhou, X, Wang, L, Li, G, Lennarz, W, Schindelin, H. | Deposit date: | 2006-07-17 | Release date: | 2007-05-29 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Studies on peptide:N-glycanase-p97 interaction suggest that p97 phosphorylation modulates endoplasmic reticulum-associated degradation. Proc.Natl.Acad.Sci.Usa, 104, 2007
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2HPJ
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![BU of 2hpj by Molmil](/molmil-images/mine/2hpj) | Crystal structure of the PUB domain of mouse PNGase | Descriptor: | GLYCEROL, PNGase | Authors: | Zhao, G, Zhou, X, Wang, L, Li, G, Lennarz, W, Schindelin, H. | Deposit date: | 2006-07-17 | Release date: | 2007-05-29 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Studies on peptide:N-glycanase-p97 interaction suggest that p97 phosphorylation modulates endoplasmic reticulum-associated degradation. Proc.Natl.Acad.Sci.Usa, 104, 2007
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8UYS
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![BU of 8uys by Molmil](/molmil-images/mine/8uys) | SARS-CoV-2 5' proximal stem-loop 5 | Descriptor: | SARS-CoV-2 RNA SL5 domain. | Authors: | Kretsch, R.C, Xu, L, Zheludev, I.N, Zhou, X, Huang, R, Nye, G, Li, S, Zhang, K, Chiu, W, Das, R. | Deposit date: | 2023-11-14 | Release date: | 2023-12-06 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses. Proc.Natl.Acad.Sci.USA, 121, 2024
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8UYJ
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![BU of 8uyj by Molmil](/molmil-images/mine/8uyj) | BtCoV-HKU5 5' proximal stem-loop 5, conformation 4 | Descriptor: | BtCoV-HKU5 5' proximal stem-loop 5, conformation 4 | Authors: | Kretsch, R.C, Xu, L, Zheludev, I.N, Zhou, X, Huang, R, Nye, G, Li, S, Zhang, K, Chiu, W, Das, R. | Deposit date: | 2023-11-13 | Release date: | 2023-12-06 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (7.3 Å) | Cite: | Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses. Proc.Natl.Acad.Sci.USA, 121, 2024
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8UYL
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![BU of 8uyl by Molmil](/molmil-images/mine/8uyl) | MERS 5' proximal stem-loop 5, conformation 2 | Descriptor: | MERS 5' proximal stem-loop 5 | Authors: | Kretsch, R.C, Xu, L, Zheludev, I.N, Zhou, X, Huang, R, Nye, G, Li, S, Zhang, K, Chiu, W, Das, R. | Deposit date: | 2023-11-13 | Release date: | 2023-12-06 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (6.4 Å) | Cite: | Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses. Proc.Natl.Acad.Sci.USA, 121, 2024
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8UYM
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![BU of 8uym by Molmil](/molmil-images/mine/8uym) | MERS 5' proximal stem-loop 5, conformation 3 | Descriptor: | MERS 5' proximal stem-loop 5 | Authors: | Kretsch, R.C, Xu, L, Zheludev, I.N, Zhou, X, Huang, R, Nye, G, Li, S, Zhang, K, Chiu, W, Das, R. | Deposit date: | 2023-11-13 | Release date: | 2023-12-06 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (6.4 Å) | Cite: | Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses. Proc.Natl.Acad.Sci.USA, 121, 2024
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8UYK
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![BU of 8uyk by Molmil](/molmil-images/mine/8uyk) | MERS 5' proximal stem-loop 5, conformation 1 | Descriptor: | MERS 5' proximal stem-loop 5 | Authors: | Kretsch, R.C, Xu, L, Zheludev, I.N, Zhou, X, Huang, R, Nye, G, Li, S, Zhang, K, Chiu, W, Das, R. | Deposit date: | 2023-11-13 | Release date: | 2023-12-06 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (6.9 Å) | Cite: | Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses. Proc.Natl.Acad.Sci.USA, 121, 2024
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8UYG
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![BU of 8uyg by Molmil](/molmil-images/mine/8uyg) | BtCoV-HKU5 5' proximal stem-loop 5, conformation 2 | Descriptor: | RNA (135-MER) | Authors: | Kretsch, R.C, Xu, L, Zheludev, I.N, Zhou, X, Huang, R, Nye, G, Li, S, Zhang, K, Chiu, W, Das, R. | Deposit date: | 2023-11-13 | Release date: | 2023-12-06 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (6.4 Å) | Cite: | Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses. Proc.Natl.Acad.Sci.USA, 121, 2024
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8UYE
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![BU of 8uye by Molmil](/molmil-images/mine/8uye) | BtCoV-HKU5 5' proximal stem-loop 5, conformation 1 | Descriptor: | BtCoV-HKU5 5' proximal stem-loop 5 | Authors: | Kretsch, R.C, Xu, L, Zheludev, I.N, Zhou, X, Huang, R, Nye, G, Li, S, Zhang, K, Chiu, W, Das, R. | Deposit date: | 2023-11-13 | Release date: | 2023-12-06 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (5.9 Å) | Cite: | Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses. Proc.Natl.Acad.Sci.USA, 121, 2024
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8UYP
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![BU of 8uyp by Molmil](/molmil-images/mine/8uyp) | SARS-CoV-1 5' proximal stem-loop 5 | Descriptor: | SARS-CoV-1 5' proximal stem-loop 5 | Authors: | Kretsch, R.C, Xu, L, Zheludev, I.N, Zhou, X, Huang, R, Nye, G, Li, S, Zhang, K, Chiu, W, Das, R. | Deposit date: | 2023-11-13 | Release date: | 2023-12-20 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (7.1 Å) | Cite: | Tertiary folds of the SL5 RNA from the 5' proximal region of SARS-CoV-2 and related coronaviruses. Proc.Natl.Acad.Sci.USA, 121, 2024
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8WUE
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![BU of 8wue by Molmil](/molmil-images/mine/8wue) | |
8W4E
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![BU of 8w4e by Molmil](/molmil-images/mine/8w4e) | |