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8E2M
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BU of 8e2m by Molmil
Bruton's tyrosine kinase (BTK) with compound 13
Descriptor: (5P)-5-[4-methyl-6-(2-methylpropyl)pyridin-3-yl]-4-oxo-N-[(1R,2S)-2-propanamidocyclopentyl]-4,5-dihydro-3H-1-thia-3,5,8-triazaacenaphthylene-2-carboxamide, TRIETHYLENE GLYCOL, Tyrosine-protein kinase BTK
Authors:Alexander, R, Milligan, C.M.
Deposit date:2022-08-15
Release date:2022-11-16
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.904 Å)
Cite:Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase.
J.Med.Chem., 65, 2022
7NAD
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BU of 7nad by Molmil
State E2 nucleolar 60S ribosomal biogenesis intermediate - Spb4 local refinement model
Descriptor: 25S rRNA, 5.8S rRNA, 60S ribosomal protein L17-A, ...
Authors:Cruz, V.E, Sekulski, K, Peddada, N, Erzberger, J.P.
Deposit date:2021-06-21
Release date:2022-11-09
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.04 Å)
Cite:Sequence-specific remodeling of a topologically complex RNP substrate by Spb4.
Nat.Struct.Mol.Biol., 29, 2022
7NAC
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BU of 7nac by Molmil
State E2 nucleolar 60S ribosomal biogenesis intermediate - Composite model
Descriptor: 25S rRNA, 25S rRNA (cytosine(2870)-C(5))-methyltransferase, 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase, ...
Authors:Cruz, V.E, Sekulski, K, Peddada, N, Erzberger, J.P.
Deposit date:2021-06-21
Release date:2022-11-09
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.04 Å)
Cite:Sequence-specific remodeling of a topologically complex RNP substrate by Spb4.
Nat.Struct.Mol.Biol., 29, 2022
7NAF
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BU of 7naf by Molmil
State E2 nucleolar 60S ribosomal biogenesis intermediate - Spb1-MTD local model
Descriptor: 25S rRNA, 25S rRNA (cytosine(2870)-C(5))-methyltransferase, 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase, ...
Authors:Cruz, V.E, Sekulski, K, Peddada, N, Erzberger, J.P.
Deposit date:2021-06-21
Release date:2022-11-09
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.13 Å)
Cite:Sequence-specific remodeling of a topologically complex RNP substrate by Spb4.
Nat.Struct.Mol.Biol., 29, 2022
3HS2
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BU of 3hs2 by Molmil
Crystal structure of PHD truncated to residue 57 in an orthorhombic space group
Descriptor: Prevent host death protein, SULFATE ION
Authors:Garcia-Pino, A, Loris, R.
Deposit date:2009-06-10
Release date:2010-06-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Allostery and intrinsic disorder mediate transcription regulation by conditional cooperativity.
Cell(Cambridge,Mass.), 142, 2010
7MU5
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BU of 7mu5 by Molmil
Human DCTPP1 bound to Triptolide
Descriptor: MAGNESIUM ION, dCTP pyrophosphatase 1, triptolide
Authors:Hauk, G, Berger, J.M.
Deposit date:2021-05-14
Release date:2022-08-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Triptolide sensitizes cancer cells to nucleoside DNA methyltransferase inhibitors through inhibition of DCTPP1 mediated cell-intrinsic resistance
To Be Published
3HRY
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BU of 3hry by Molmil
Crystal structure of PHD in a trigonal space group and partially disordered
Descriptor: Prevent host death protein
Authors:Garcia-Pino, A, Loris, R.
Deposit date:2009-06-10
Release date:2010-06-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Allostery and intrinsic disorder mediate transcription regulation by conditional cooperativity.
Cell(Cambridge,Mass.), 142, 2010
3K33
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BU of 3k33 by Molmil
Crystal structure of the Phd-Doc complex
Descriptor: ACETATE ION, Death on curing protein, Polypeptide of unknown amino acids and source, ...
Authors:Loris, R, Garcia-Pino, A.
Deposit date:2009-10-01
Release date:2010-08-18
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Allostery and intrinsic disorder mediate transcription regulation by conditional cooperativity.
Cell(Cambridge,Mass.), 142, 2010
7R7O
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BU of 7r7o by Molmil
Structure of methyltransferase domain of Spb1 boudn to SAM
Descriptor: AdoMet-dependent rRNA methyltransferase SPB1, S-ADENOSYLMETHIONINE
Authors:Cruz, V.E, Sekulski, K, Peddada, N, Erzberger, J.P.
Deposit date:2021-06-25
Release date:2022-06-29
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Post-catalytic rRNA binding by the DEAD-box ATPase Spb4 and methyltransferase Spb1 guide the late nucleolar assembly of 60S ribosomes
To Be Published
7R6K
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BU of 7r6k by Molmil
State E2 nucleolar 60S ribosomal intermediate - Model for Noc2/Noc3 region
Descriptor: 25S rRNA, 25S rRNA (cytosine(2870)-C(5))-methyltransferase, 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase, ...
Authors:Cruz, V.E, Sekulski, K, Peddada, N, Erzberger, J.P.
Deposit date:2021-06-22
Release date:2022-11-09
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.17 Å)
Cite:Sequence-specific remodeling of a topologically complex RNP substrate by Spb4.
Nat.Struct.Mol.Biol., 29, 2022
7R7C
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BU of 7r7c by Molmil
State E2 nucleolar 60S ribosomal biogenesis intermediate - L1 stalk local model
Descriptor: 25S rRNA, 25S rRNA (cytosine(2870)-C(5))-methyltransferase, 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase, ...
Authors:Cruz, V.E, Sekulski, K, Peddada, N, Erzberger, J.P.
Deposit date:2021-06-24
Release date:2022-11-09
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.71 Å)
Cite:Sequence-specific remodeling of a topologically complex RNP substrate by Spb4.
Nat.Struct.Mol.Biol., 29, 2022
7R72
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BU of 7r72 by Molmil
State E1 nucleolar 60S ribosome biogenesis intermediate - Spb4 local model
Descriptor: 25S rRNA, 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase, 5.8S rRNA, ...
Authors:Cruz, V.E, Sekulski, K, Peddada, N, Erzberger, J.P.
Deposit date:2021-06-24
Release date:2022-11-09
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.07 Å)
Cite:Sequence-specific remodeling of a topologically complex RNP substrate by Spb4.
Nat.Struct.Mol.Biol., 29, 2022
7R7A
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BU of 7r7a by Molmil
State E1 nucleolar 60S ribosome biogenesis intermediate - Composite model
Descriptor: 25S rRNA, 25S rRNA (cytosine(2870)-C(5))-methyltransferase, 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase, ...
Authors:Cruz, V.E, Sekulski, K, Peddada, N, Erzberger, J.P.
Deposit date:2021-06-24
Release date:2022-11-09
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.04 Å)
Cite:Sequence-specific remodeling of a topologically complex RNP substrate by Spb4.
Nat.Struct.Mol.Biol., 29, 2022
7R6Q
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BU of 7r6q by Molmil
State E2 nucleolar 60S ribosome biogenesis intermediate - Foot region model
Descriptor: 25S rRNA, 5.8S rRNA, 60S ribosomal protein L13-A, ...
Authors:Cruz, V.E, Sekulski, K, Peddada, N, Erzberger, J.P.
Deposit date:2021-06-23
Release date:2022-11-09
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (2.98 Å)
Cite:Sequence-specific remodeling of a topologically complex RNP substrate by Spb4.
Nat.Struct.Mol.Biol., 29, 2022
7U0H
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BU of 7u0h by Molmil
State NE1 nucleolar 60S ribosome biogenesis intermediate - Overall model
Descriptor: 25S rRNA, 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase, 5.8S rRNA, ...
Authors:Cruz, V.E, Sekulski, K, Peddada, N, Erzberger, J.P.
Deposit date:2022-02-18
Release date:2022-12-14
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (2.76 Å)
Cite:Sequence-specific remodeling of a topologically complex RNP substrate by Spb4.
Nat.Struct.Mol.Biol., 29, 2022
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