6WE5

Crystal structure of an inorganic pyrophosphatase from Chlamydia trachomatis D/UW-3/Cx

Summary for 6WE5

• Entry DOI: 10.2210/pdb6we5/pdb
• Descriptor: Inorganic pyrophosphatase, SODIUM ION (3 entities in total)
• Functional Keywords: national institute of allergy and infectious diseases, niaid, structural genomics, sexually transmitted infections, sti, std, pyrophosphate phospho-hydrolase, seattle structural genomics center for infectious disease, ssgcid, hydrolase
• Biological source: Chlamydia trachomatis (strain D/UW-3/Cx)
• Total number of polymer chains: 3
• Total formula weight: 73409.65

Authors

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2020-04-01, release date: 2020-04-08, Last modification date: 2023-10-18)

Primary citation

Maddy, J.,Staker, B.L.,Subramanian, S.,Abendroth, J.,Edwards, T.E.,Myler, P.J.,Hybiske, K.,Asojo, O.A.
Crystal structure of an inorganic pyrophosphatase from Chlamydia trachomatis D/UW-3/Cx.
Acta Crystallogr.,Sect.F, 78:135-142, 2022

PubMed Abstract: Chlamydia trachomatis is the leading cause of bacterial sexually transmitted infections globally and is one of the most commonly reported infections in the United States. There is a need to develop new therapeutics due to drug resistance and the failure of current treatments to clear persistent infections. Structures of potential C. trachomatis rational drug-discovery targets, including C. trachomatis inorganic pyrophosphatase (CtPPase), have been determined by the Seattle Structural Genomics Center for Infectious Disease. Inorganic pyrophosphatase hydrolyzes inorganic pyrophosphate during metabolism. Furthermore, bacterial inorganic pyrophosphatases have shown promise for therapeutic discovery. Here, a 2.2 Å resolution X-ray structure of CtPPase is reported. The crystal structure of CtPPase reveals shared structural features that may facilitate the repurposing of inhibitors identified for bacterial inorganic pyrophosphatases as starting points for new therapeutics for C. trachomatis.

PubMed: 35234139
DOI: 10.1107/S2053230X22002138

Experimental method

X-RAY DIFFRACTION (2.25 Å)