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3R88
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BU of 3r88 by Molmil
Anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis (complex with inhibitor ACS145)
Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-amino-4,5-dimethoxybenzoic acid, Anthranilate phosphoribosyltransferase, ...
Authors:Castell, A, Short, F.L, Lott, J.S.
Deposit date:2011-03-23
Release date:2012-09-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition.
Biochemistry, 52, 2013
4OWV
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BU of 4owv by Molmil
Anthranilate phosphoribosyl transferase from Mycobacterium tuberculosis in complex with anthranilate
Descriptor: 2-AMINOBENZOIC ACID, Anthranilate phosphoribosyltransferase, GLYCEROL, ...
Authors:Castell, A, Cookson, T.V.M, Short, F.L, Lott, J.S.
Deposit date:2014-02-04
Release date:2014-04-23
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis.
Biochem.J., 461, 2014
4OWQ
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BU of 4owq by Molmil
Anthranilate phosphoribosyl transferase from Mycobacterium tuberculosis in complex with 3-methylanthranilate, PRPP and Magnesium
Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-azanyl-3-methyl-benzoic acid, Anthranilate phosphoribosyltransferase, ...
Authors:Castell, A, Cookson, T.V.M, Short, F.L, Lott, J.S.
Deposit date:2014-02-03
Release date:2014-04-23
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis.
Biochem.J., 461, 2014
4OWS
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BU of 4ows by Molmil
Anthranilate phosphoribosyl transferase from Mycobacterium tuberculosis in complex with 4-methylanthranilate, PRPP and Magnesium
Descriptor: 2-azanyl-4-methyl-benzoic acid, Anthranilate phosphoribosyltransferase, IMIDAZOLE, ...
Authors:Castell, A, Cookson, T.V.M, Short, F.L, Lott, J.S.
Deposit date:2014-02-03
Release date:2014-04-23
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis.
Biochem.J., 461, 2014
3QQS
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BU of 3qqs by Molmil
Anthranilate phosphoribosyltransferase (TRPD) from Mycobacterium tuberculosis (complex with inhibitor ACS172)
Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2,2'-iminodibenzoic acid, Anthranilate phosphoribosyltransferase, ...
Authors:Castell, A, Short, F.L, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-02-16
Release date:2012-08-22
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition.
Biochemistry, 52, 2013
3QR9
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BU of 3qr9 by Molmil
Anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis (apo structure)
Descriptor: Anthranilate phosphoribosyltransferase, GLYCEROL
Authors:Castell, A, Short, F.L, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-02-17
Release date:2011-06-15
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition.
Biochemistry, 52, 2013
3QS8
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BU of 3qs8 by Molmil
Anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis (complex with inhibitor ACS174)
Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-benzylbenzoic acid, Anthranilate phosphoribosyltransferase, ...
Authors:Castell, A, Short, F.L, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-02-20
Release date:2012-08-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition.
Biochemistry, 52, 2013
3ST6
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BU of 3st6 by Molmil
Structure of a M. tuberculosis Synthase, MbtI, in Complex with an Isochorismate Analogue Inhibitor
Descriptor: 3-[(1-carboxyethenyl)oxy]-2-hydroxybenzoic acid, Isochorismate synthase/isochorismate-pyruvate lyase mbtI
Authors:Chi, G, Bulloch, E.M.M, Manos-Turvey, A, Payne, R.J, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-07-08
Release date:2012-05-30
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis
Biochemistry, 51, 2012
3R6C
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BU of 3r6c by Molmil
Anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis (complex with inhibitor ACS179)
Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 8-methoxyphenanthro[3,4-d][1,3]dioxole-5,6-dicarboxylic acid, Anthranilate phosphoribosyltransferase, ...
Authors:Castell, A, Short, F.L, Lott, J.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-03-21
Release date:2012-09-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition.
Biochemistry, 52, 2013
3TWP
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BU of 3twp by Molmil
Crystal structure of M. tuberculosis TrpD in complex with an inhibitor
Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 2-HYDROXYBENZOIC ACID, Anthranilate phosphoribosyltransferase, ...
Authors:Castell, A, Short, F.L, Lott, J.S.
Deposit date:2011-09-22
Release date:2012-09-26
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition.
Biochemistry, 52, 2013
2M3O
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BU of 2m3o by Molmil
Structure and dynamics of a human Nedd4 WW domain-ENaC complex
Descriptor: Amiloride-sensitive sodium channel subunit alpha, E3 ubiquitin-protein ligase NEDD4
Authors:Bobby, R, Medini, K, Neudecker, P, Lee, V, MacDonald, F.J, Brimble, M.A, Lott, J, Dingley, A.J.
Deposit date:2013-01-23
Release date:2013-08-28
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Structure and dynamics of human Nedd4-1 WW3 in complex with the alpha ENaC PY motif.
Biochim.Biophys.Acta, 1834, 2013
6OGD
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BU of 6ogd by Molmil
Cryo-EM structure of YenTcA in its prepore state
Descriptor: Chitinase 2, Toxin subunit YenA1, Toxin subunit YenA2
Authors:Piper, S.J, Brillault, L, Box, J.K, Landsberg, M.J.
Deposit date:2019-04-02
Release date:2019-05-08
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:Cryo-EM structures of the pore-forming A subunit from the Yersinia entomophaga ABC toxin.
Nat Commun, 10, 2019
4WPY
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BU of 4wpy by Molmil
Racemic crystal structure of Rv1738 from Mycobacterium tuberculosis (Form-II)
Descriptor: GLYCEROL, protein DL-Rv1738, trifluoroacetic acid
Authors:Bunker, R.D, Mandal, K, Kent, S.B.H, Baker, E.N.
Deposit date:2014-10-21
Release date:2015-03-18
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:A functional role of Rv1738 in Mycobacterium tuberculosis persistence suggested by racemic protein crystallography.
Proc.Natl.Acad.Sci.USA, 112, 2015
4WSP
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BU of 4wsp by Molmil
Racemic crystal structure of Rv1738 from Mycobacterium tuberculosis (Form-I)
Descriptor: CHLORIDE ION, protein DL-Rv1738
Authors:Bunker, R.D, Mandal, K, Kent, S.B.H, Baker, E.N.
Deposit date:2014-10-28
Release date:2015-03-18
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:A functional role of Rv1738 in Mycobacterium tuberculosis persistence suggested by racemic protein crystallography.
Proc.Natl.Acad.Sci.USA, 112, 2015
6BP6
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BU of 6bp6 by Molmil
Crystal structure of Commd9 COMM domain
Descriptor: COMM domain-containing protein 9
Authors:Healy, M.D, Chandra, M, Collins, B.M, Ghai, R.
Deposit date:2017-11-22
Release date:2018-08-15
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Structural insights into the architecture and membrane interactions of the conserved COMMD proteins.
Elife, 7, 2018
3KGF
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BU of 3kgf by Molmil
The structure of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis complexed with phenylalanine and tryptophan
Descriptor: CHLORIDE ION, GLYCEROL, MANGANESE (II) ION, ...
Authors:Parker, E.J, Jameson, G.B, Jiao, W, Webby, C.J, Baker, E.N, Baker, H.M, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2009-10-29
Release date:2010-07-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Synergistic allostery, a sophisticated regulatory network for the control of aromatic amino acid biosynthesis in Mycobacterium tuberculosis
J.Biol.Chem., 285, 2010
5ID2
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BU of 5id2 by Molmil
Asymmetry in the active site of Mycobacterium tuberculosis AhpE upon exposure to Mycothiol
Descriptor: ACETATE ION, GLYCEROL, Putative peroxiredoxin Rv2238c
Authors:Kumar, A, Balakrishna, A.M, Gruber, G.
Deposit date:2016-02-23
Release date:2016-08-03
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Redox chemistry of Mycobacterium tuberculosis alkylhydroperoxide reductase E (AhpE): Structural and mechanistic insight into a mycoredoxin-1 independent reductive pathway of AhpE via mycothiol
Free Radic. Biol. Med., 97, 2016
4X1U
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BU of 4x1u by Molmil
The structure of AhpE from Mycobacterium tuberculosis revisited
Descriptor: GLYCEROL, Putative peroxiredoxin MT2298
Authors:Pallo, A, Messens, J.
Deposit date:2014-11-25
Release date:2016-07-27
Last modified:2016-08-10
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Revisiting sulfur H-bonds in proteins: The example of peroxiredoxin AhpE.
Sci Rep, 6, 2016
4X0X
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BU of 4x0x by Molmil
The structure of AhpE from Mycobacterium tuberculosis revisited
Descriptor: Putative peroxiredoxin MT2298
Authors:Pallo, A, Messens, J.
Deposit date:2014-11-24
Release date:2016-07-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Revisiting sulfur H-bonds in proteins: The example of peroxiredoxin AhpE.
Sci Rep, 6, 2016
3NV8
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BU of 3nv8 by Molmil
The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase in complex with phosphoenol pyruvate and manganese (thesit-free)
Descriptor: CHLORIDE ION, GLYCEROL, MANGANESE (II) ION, ...
Authors:Parker, E.J, Jameson, G.B, Jiao, W, Hutton, R.H, Webby, C.J, Baker, E.N, Baker, H.M.
Deposit date:2010-07-08
Release date:2010-07-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Synergistic allostery, a sophisticated regulatory network for the control of aromatic amino acid biosynthesis in Mycobacterium tuberculosis
J.Biol.Chem., 285, 2010
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