8YMZ
| Structure of ZBTB43 in complex with CACA containing B-form DNA | Descriptor: | DNA (5'-D(*AP*AP*GP*TP*GP*TP*GP*TP*AP*TP*GP*TP*GP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*CP*AP*CP*AP*TP*AP*CP*AP*CP*AP*CP*T)-3'), ZINC ION, ... | Authors: | Li, X, Yang, Y. | Deposit date: | 2024-03-10 | Release date: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Structural insights into the recognition of purine-pyrimidine dinucleotide repeats by zinc finger protein ZBTB43. Febs J., 2024
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1IYI
| Crystal structure of hematopoietic prostaglandin D synthase | Descriptor: | CALCIUM ION, GLUTATHIONE, HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE | Authors: | Inoue, T. | Deposit date: | 2002-08-26 | Release date: | 2003-04-08 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Mechanism of metal activation of human hematopoietic prostaglandin D synthase NAT.STRUCT.BIOL., 10, 2003
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1CGO
| CYTOCHROME C' | Descriptor: | CYTOCHROME C, HEME C | Authors: | Dobbs, A.J, Faber, H.R, Anderson, B.F, Baker, E.N. | Deposit date: | 1995-05-01 | Release date: | 1995-07-31 | Last modified: | 2020-01-22 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Three-dimensional structure of cytochrome c' from two Alcaligenes species and the implications for four-helix bundle structures. Acta Crystallogr.,Sect.D, 52, 1996
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1CGN
| CYTOCHROME C' | Descriptor: | CYTOCHROME C, HEME C | Authors: | Dobbs, A.J, Faber, H.R, Anderson, B.F, Baker, E.N. | Deposit date: | 1995-05-01 | Release date: | 1995-07-31 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Three-dimensional structure of cytochrome c' from two Alcaligenes species and the implications for four-helix bundle structures. Acta Crystallogr.,Sect.D, 52, 1996
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1MHO
| THE 2.0 A STRUCTURE OF HOLO S100B FROM BOVINE BRAIN | Descriptor: | CALCIUM ION, S-100 PROTEIN | Authors: | Matsumura, H, Shiba, T, Inoue, T, Harada, S, Yasushi, K.A.I. | Deposit date: | 1997-09-11 | Release date: | 1998-11-18 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A novel mode of target recognition suggested by the 2.0 A structure of holo S100B from bovine brain. Structure, 6, 1998
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1BQ5
| NITRITE REDUCTASE FROM ALCALIGENES XYLOSOXIDANS GIFU 1051 | Descriptor: | COPPER (II) ION, NITRITE REDUCTASE | Authors: | Inoue, T, Gotowda, M, Deligeer, Suzuki, S, Kataoka, K, Yamaguchi, K, Watanabe, H, Goho, M, Yasushi, K.A.I. | Deposit date: | 1998-08-21 | Release date: | 1999-08-21 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Type 1 Cu structure of blue nitrite reductase from Alcaligenes xylosoxidans GIFU 1051 at 2.05 A resolution: comparison of blue and green nitrite reductases. J.Biochem.(Tokyo), 124, 1998
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6DSS
| Re-refinement of P. falciparum orotidine 5'-monophosphate decarboxylase | Descriptor: | Orotidine 5'-monophosphate decarboxylase, URIDINE-5'-MONOPHOSPHATE | Authors: | Brandt, G.S, Novak, W.R.P. | Deposit date: | 2018-06-14 | Release date: | 2018-10-17 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.599 Å) | Cite: | Re-refinement of Plasmodium falciparum orotidine 5'-monophosphate decarboxylase provides a clearer picture of an important malarial drug target. Acta Crystallogr F Struct Biol Commun, 74, 2018
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6DSQ
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6DSR
| Re-refinement of P. falciparum orotidine 5'-monophosphate decarboxylase | Descriptor: | Orotidine 5'-monophosphate decarboxylase, URIDINE-5'-MONOPHOSPHATE | Authors: | Brandt, G.S, Novak, W.R.P. | Deposit date: | 2018-06-14 | Release date: | 2018-10-17 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.597 Å) | Cite: | Re-refinement of Plasmodium falciparum orotidine 5'-monophosphate decarboxylase provides a clearer picture of an important malarial drug target. Acta Crystallogr F Struct Biol Commun, 74, 2018
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2ZXC
| Ceramidase complexed with C2 | Descriptor: | DIMETHYL SULFOXIDE, FORMIC ACID, MAGNESIUM ION, ... | Authors: | Okano, H, Inoue, T, Okino, N, Kakuta, Y, Matsumura, H, Ito, M. | Deposit date: | 2008-12-22 | Release date: | 2009-02-03 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Mechanistic insights into the hydrolysis and synthesis of ceramide by neutral ceramidase. J.Biol.Chem., 284, 2009
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2ZWS
| Crystal Structure Analysis of neutral ceramidase from Pseudomonas aeruginosa | Descriptor: | FORMIC ACID, GLYCEROL, MAGNESIUM ION, ... | Authors: | Kakuta, Y, Okino, N, Inoue, T, Okano, H, Ito, M. | Deposit date: | 2008-12-17 | Release date: | 2009-03-03 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Mechanistic insights into the hydrolysis and synthesis of ceramide by neutral ceramidase. J.Biol.Chem., 284, 2009
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2ZA3
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2ZA1
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2ZA2
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3MO0
| Human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E11 | Descriptor: | 1,2-ETHANEDIOL, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, ... | Authors: | Chang, Y, Horton, J.R, Cheng, X. | Deposit date: | 2010-04-22 | Release date: | 2010-06-30 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.78 Å) | Cite: | Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases. J.Mol.Biol., 400, 2010
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3MO5
| Human G9a-like (GLP, also known as EHMT1) in complex with inhibitor E72 | Descriptor: | 7-[(5-aminopentyl)oxy]-N~4~-[1-(5-aminopentyl)piperidin-4-yl]-N~2~-[3-(dimethylamino)propyl]-6-methoxyquinazoline-2,4-diamine, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, ... | Authors: | Chang, Y, Horton, J.R, Cheng, X. | Deposit date: | 2010-04-22 | Release date: | 2010-06-30 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases. J.Mol.Biol., 400, 2010
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7ZZO
| HDAC2 in complex with an inhibitor | Descriptor: | 2-(cyclohexylazaniumyl)ethanesulfonate, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Cleasby, A, Tisi, D. | Deposit date: | 2022-05-25 | Release date: | 2022-09-21 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
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7ZZT
| Ligand binding to HDAC2 | Descriptor: | 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, CALCIUM ION, ... | Authors: | Cleasby, A, Tisi, D. | Deposit date: | 2022-05-26 | Release date: | 2022-09-21 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
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7ZZS
| HDAC2 complexed with an inhibitory ligand | Descriptor: | (5~{S})-5-(4-chlorophenyl)pyrrolidin-2-one, 1,2-ETHANEDIOL, 2-(cyclohexylazaniumyl)ethanesulfonate, ... | Authors: | Cleasby, A, Tisi, D. | Deposit date: | 2022-05-26 | Release date: | 2022-09-21 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
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7ZZP
| Structure of HDAC2 complexed with an inhibitory ligand | Descriptor: | (2S)-2-HYDROXYPROPANOIC ACID, 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ... | Authors: | Cleasby, A, Tisi, D. | Deposit date: | 2022-05-25 | Release date: | 2022-09-21 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
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7ZZR
| HDAC2 in complex with inhibitory ligand | Descriptor: | 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, CALCIUM ION, ... | Authors: | Cleasby, A, Tisi, D. | Deposit date: | 2022-05-26 | Release date: | 2022-09-21 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.168 Å) | Cite: | Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
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7ZZW
| Ligand binding to HDAC2 | Descriptor: | 1,2-ETHANEDIOL, 2-(cyclohexylazaniumyl)ethanesulfonate, CALCIUM ION, ... | Authors: | Cleasby, A, Tisi, D. | Deposit date: | 2022-05-26 | Release date: | 2022-09-21 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
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8A0B
| Inhibitor binding to HDAC2 | Descriptor: | 1,2-ETHANEDIOL, 1,3-dihydroisoindol-2-yl-[(2R,4S)-4-phenylpyrrolidin-1-ium-2-yl]methanone, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ... | Authors: | Cleasby, A, Tisi, D. | Deposit date: | 2022-05-27 | Release date: | 2022-09-21 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.746 Å) | Cite: | Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
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7ZZU
| Inhibitory Ligand binding to HDAC2 | Descriptor: | 1,2-ETHANEDIOL, 2-[4-[(2~{R},4~{S})-4-phenylpyrrolidin-2-yl]carbonylpiperazin-1-yl]pyridine-3-carbonitrile, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ... | Authors: | Cleasby, A, Tisi, D. | Deposit date: | 2022-05-26 | Release date: | 2022-09-21 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
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1AY4
| AROMATIC AMINO ACID AMINOTRANSFERASE WITHOUT SUBSTRATE | Descriptor: | AROMATIC AMINO ACID AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE | Authors: | Okamoto, A, Hirotsu, K, Kagamiyama, H. | Deposit date: | 1997-11-14 | Release date: | 1998-10-14 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (2.33 Å) | Cite: | Crystal structures of Paracoccus denitrificans aromatic amino acid aminotransferase: a substrate recognition site constructed by rearrangement of hydrogen bond network. J.Mol.Biol., 280, 1998
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