7WMZ
 
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8KIA
 
 | Tomato spotted wilt virus L protein (apo state) | Descriptor: | RNA-directed RNA polymerase L | Authors: | Cao, L, Wang, X. | Deposit date: | 2023-08-23 | Release date: | 2024-09-25 | Last modified: | 2025-07-02 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structural basis for the activation of plant bunyavirus replication machinery and its dual-targeted inhibition by ribavirin. Nat.Plants, 11, 2025
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8KI8
 
 | structure of Tomato spotted wilt virus L protein binding to 5'vRNA | Descriptor: | RNA (5'-R(P*AP*GP*AP*GP*CP*AP*AP*UP*CP*A)-3'), RNA-directed RNA polymerase L | Authors: | Cao, L, Wang, X. | Deposit date: | 2023-08-23 | Release date: | 2024-09-25 | Last modified: | 2025-06-25 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural basis for the activation of plant bunyavirus replication machinery and its dual-targeted inhibition by ribavirin. Nat.Plants, 11, 2025
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8KI7
 
 | Structure of Tomato spotted wilt virus L protein contained endoH domain binding to 3'5'vRNA | Descriptor: | RNA (5'-R(P*AP*CP*CP*UP*GP*AP*UP*UP*GP*CP*UP*CP*U)-3'), RNA (5'-R(P*AP*GP*AP*GP*CP*AP*AP*UP*CP*A)-3'), RNA (5'-R(P*GP*CP*AP*AP*UP*CP*AP*GP*G)-3'), ... | Authors: | Cao, L, Wang, X. | Deposit date: | 2023-08-23 | Release date: | 2024-09-25 | Last modified: | 2025-07-02 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural basis for the activation of plant bunyavirus replication machinery and its dual-targeted inhibition by ribavirin. Nat.Plants, 11, 2025
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8KI6
 
 | Structure of tomato spotted wilt virus L protein binding to Ribavirin | Descriptor: | 1-(beta-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide, RNA-directed RNA polymerase L | Authors: | Cao, L, Wang, X. | Deposit date: | 2023-08-23 | Release date: | 2024-09-25 | Last modified: | 2025-07-02 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis for the activation of plant bunyavirus replication machinery and its dual-targeted inhibition by ribavirin. Nat.Plants, 11, 2025
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8WGI
 
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8WGJ
 
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8I54
 
 | Lb2Cas12a RNA DNA complex | Descriptor: | DNA (25-MER), DNA (5'-D(*AP*GP*TP*GP*CP*TP*TP*TP*A)-3'), Lb2Cas12a, ... | Authors: | Li, J, Sivaraman, J, Satoru, M. | Deposit date: | 2023-01-24 | Release date: | 2023-02-22 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.95 Å) | Cite: | Structures of apo Cas12a and its complex with crRNA and DNA reveal the dynamics of ternary complex formation and target DNA cleavage. Plos Biol., 21, 2023
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7Y8B
 
 | Crystal structure of CotA laccase complexed with syringic acid | Descriptor: | 3,5-dimethoxy-4-oxidanyl-benzoic acid, COPPER (II) ION, Spore coat protein A, ... | Authors: | Liu, Z.C, Xie, T, Wang, G.G. | Deposit date: | 2022-06-23 | Release date: | 2023-06-28 | Last modified: | 2024-11-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Molecular insights into substrate promiscuity of CotA laccase catalyzing lignin-phenol derivatives. Int.J.Biol.Macromol., 256, 2023
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7Y8C
 
 | Crystal structure of CotA laccase complexed with syringaldehyde | Descriptor: | 3,5-dimethoxy-4-oxidanyl-benzaldehyde, COPPER (II) ION, Spore coat protein A, ... | Authors: | Liu, Z.C, Xie, T, Wang, G.G. | Deposit date: | 2022-06-23 | Release date: | 2023-06-28 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Molecular insights into substrate promiscuity of CotA laccase catalyzing lignin-phenol derivatives. Int.J.Biol.Macromol., 256, 2023
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9F0H
 
 | cryo-EM structure of carboxysomal mini-shell icosahedral assembly from co-expression of CsoS1C, CsoS4A, and CsoS2-C (T = 9) | Descriptor: | Carboxysome assembly protein CsoS2B, Carboxysome shell protein CsoS1C, Carboxysome shell vertex protein CsoS4A, ... | Authors: | Wang, P, Marles-Wright, J, Liu, L.N. | Deposit date: | 2024-04-16 | Release date: | 2024-12-11 | Method: | ELECTRON MICROSCOPY (1.8 Å) | Cite: | Molecular principles of the assembly and construction of a carboxysome shell. Sci Adv, 10, 2024
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5JWB
 
 | Structure of NDH2 from plasmodium falciparum in complex with NADH | Descriptor: | 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, ACETATE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Yu, Y, Li, X.L. | Deposit date: | 2016-05-12 | Release date: | 2017-03-29 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Target Elucidation by Cocrystal Structures of NADH-Ubiquinone Oxidoreductase of Plasmodium falciparum (PfNDH2) with Small Molecule To Eliminate Drug-Resistant Malaria J. Med. Chem., 60, 2017
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1WCI
 
 | Reactivity modulation of human branched-chain alpha-ketoacid dehydrogenase by an internal molecular switch | Descriptor: | 2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, C2-1-HYDROXY-3-METHYL-BUTYL-THIAMIN, ... | Authors: | Machius, M, Wynn, R.M, Chuang, J.L, Tomchick, D.R, Brautigam, C.A, Chuang, D.T. | Deposit date: | 2004-11-16 | Release date: | 2006-02-16 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | A Versatile Conformational Switch Regulates Reactivity in Human Branched-Chain Alpha-Ketoacid Dehydrogenase. Structure, 14, 2006
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5JWC
 
 | Structure of NDH2 from plasmodium falciparum in complex with RYL-552 | Descriptor: | 5-fluoro-3-methyl-2-{4-[4-(trifluoromethoxy)benzyl]phenyl}quinolin-4(1H)-one, FLAVIN-ADENINE DINUCLEOTIDE, FRAGMENT OF TRITON X-100, ... | Authors: | Yu, Y. | Deposit date: | 2016-05-12 | Release date: | 2017-03-22 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.051 Å) | Cite: | Target Elucidation by Cocrystal Structures of NADH-Ubiquinone Oxidoreductase of Plasmodium falciparum (PfNDH2) with Small Molecule To Eliminate Drug-Resistant Malaria J. Med. Chem., 60, 2017
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5D1M
 
 | Crystal Structure of UbcH5B in Complex with the RING-U5BR Fragment of AO7 (P199A) | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase RNF25, ... | Authors: | Liang, Y.-H, Li, S, Weissman, A.M, Ji, X. | Deposit date: | 2015-08-04 | Release date: | 2015-10-28 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.581 Å) | Cite: | Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B. J.Biol.Chem., 290, 2015
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6IGD
 
 | Crystal structure of HPV58/33 chimeric L1 pentamer | Descriptor: | Major capsid protein L1 | Authors: | Li, Z.H, Song, S, He, M.Z, Gu, Y, Li, S.W. | Deposit date: | 2018-09-25 | Release date: | 2018-11-21 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity. Nat Commun, 9, 2018
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6IGE
 
 | Crystal structure of Human Papillomavirus type 33 pentamer | Descriptor: | Major capsid protein L1 | Authors: | Li, Z.H, Song, S, He, M.Z, Gu, Y, Li, S.W. | Deposit date: | 2018-09-25 | Release date: | 2018-12-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity. Nat Commun, 9, 2018
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6IGF
 
 | Crystal structure of Human Papillomavirus type 52 pentamer | Descriptor: | Major capsid protein L1 | Authors: | Li, Z.H, Song, S, He, M.Z, Gu, Y, Li, S.W. | Deposit date: | 2018-09-25 | Release date: | 2018-11-28 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.751 Å) | Cite: | Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity. Nat Commun, 9, 2018
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5Y9F
 
 | Crystal structure of HPV59 pentamer in complex with the Fab fragment of antibody 28F10 | Descriptor: | Major capsid protein L1, heavy chain of Fab fragment of antibody 28F10, light chains of Fab fragment of antibody 28F10 | Authors: | Li, S.W, Li, Z.H. | Deposit date: | 2017-08-24 | Release date: | 2017-10-25 | Last modified: | 2024-11-13 | Method: | X-RAY DIFFRACTION (3.35 Å) | Cite: | Crystal Structures of Two Immune Complexes Identify Determinants for Viral Infectivity and Type-Specific Neutralization of Human Papillomavirus. MBio, 8, 2017
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5Y9C
 
 | Crystal structure of HPV58 pentamer in complex with the Fab fragment of antibody A12A3 | Descriptor: | Major capsid protein L1, heavy chain of Fab fragment of antibody A12A3, light chain of Fab fragment of antibody A12A3 | Authors: | Li, S.W, Li, Z.H. | Deposit date: | 2017-08-24 | Release date: | 2017-10-25 | Last modified: | 2024-11-06 | Method: | X-RAY DIFFRACTION (3.443 Å) | Cite: | Crystal Structures of Two Immune Complexes Identify Determinants for Viral Infectivity and Type-Specific Neutralization of Human Papillomavirus. MBio, 8, 2017
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5Y9E
 
 | Crystal structure of HPV58 pentamer | Descriptor: | GLYCEROL, MAGNESIUM ION, Major capsid protein L1 | Authors: | Li, S.W, Li, Z.H. | Deposit date: | 2017-08-24 | Release date: | 2017-10-25 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.042 Å) | Cite: | Crystal Structures of Two Immune Complexes Identify Determinants for Viral Infectivity and Type-Specific Neutralization of Human Papillomavirus. MBio, 8, 2017
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3JUE
 
 | Crystal Structure of ArfGAP and ANK repeat domain of ACAP1 | Descriptor: | ARFGAP with coiled-coil, ANK repeat and PH domain-containing protein 1, SULFATE ION, ... | Authors: | Pang, X, Zhang, K, Ma, J, Zhou, Q, Sun, F. | Deposit date: | 2009-09-15 | Release date: | 2010-09-22 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Mechanistic insights into regulated cargo binding by ACAP1 protein J.Biol.Chem., 287, 2012
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3RWP
 
 | Discovery of a Novel, Potent and Selective Inhibitor of 3-Phosphoinositide Dependent Kinase (PDK1) | Descriptor: | 3-phosphoinositide-dependent protein kinase 1, GLYCEROL, SULFATE ION, ... | Authors: | Greasley, S.E, Hickey, M, Ferre, R.-A, Krauss, M, Cronin, C. | Deposit date: | 2011-05-09 | Release date: | 2011-11-16 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Discovery of Novel, Potent, and Selective Inhibitors of 3-Phosphoinositide-Dependent Kinase (PDK1). J.Med.Chem., 54, 2011
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3RWQ
 
 | Discovery of a Novel, Potent and Selective Inhibitor of 3-Phosphoinositide Dependent Kinase (PDK1) | Descriptor: | 3-phosphoinositide-dependent protein kinase 1, GLYCEROL, SULFATE ION, ... | Authors: | Kazmirski, S, Kohls, D. | Deposit date: | 2011-05-09 | Release date: | 2011-11-16 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Discovery of Novel, Potent, and Selective Inhibitors of 3-Phosphoinositide-Dependent Kinase (PDK1). J.Med.Chem., 54, 2011
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1JI6
 
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