1NEX
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![BU of 1nex by Molmil](/molmil-images/mine/1nex) | Crystal Structure of ScSkp1-ScCdc4-CPD peptide complex | Descriptor: | CDC4 protein, Centromere DNA-binding protein complex CBF3 subunit D, GLL(TPO)PPQSG | Authors: | Orlicky, S, Tang, X, Willems, A, Tyers, M, Sicheri, F. | Deposit date: | 2002-12-12 | Release date: | 2003-02-18 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural Basis for Phosphodependent Substrate Selection and
Orientation by the SCFCdc4 Ubiquitin Ligase Cell(Cambridge,Mass.), 112, 2003
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1QCF
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![BU of 1qcf by Molmil](/molmil-images/mine/1qcf) | CRYSTAL STRUCTURE OF HCK IN COMPLEX WITH A SRC FAMILY-SELECTIVE TYROSINE KINASE INHIBITOR | Descriptor: | 1-TER-BUTYL-3-P-TOLYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE, Tyrosine-protein kinase HCK | Authors: | Schindler, T, Sicheri, F, Pico, A, Gazit, A, Levitzki, A, Kuriyan, J. | Deposit date: | 1999-05-04 | Release date: | 1999-06-08 | Last modified: | 2022-12-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor. Mol.Cell, 3, 1999
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1Q8H
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![BU of 1q8h by Molmil](/molmil-images/mine/1q8h) | Crystal structure of porcine osteocalcin | Descriptor: | CALCIUM ION, Osteocalcin | Authors: | Hoang, Q.Q, Sicheri, F, Howard, A.J, Yang, D.S. | Deposit date: | 2003-08-21 | Release date: | 2003-11-11 | Last modified: | 2019-02-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Bone recognition mechanism of porcine osteocalcin from crystal structure. Nature, 425, 2003
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1JPA
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![BU of 1jpa by Molmil](/molmil-images/mine/1jpa) | Crystal Structure of unphosphorylated EphB2 receptor tyrosine kinase and juxtamembrane region | Descriptor: | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, neural kinase, Nuk=Eph/Elk/Eck family receptor-like tyrosine kinase | Authors: | Wybenga-Groot, L.E, Pawson, T, Sicheri, F. | Deposit date: | 2001-08-01 | Release date: | 2001-10-03 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region. Cell(Cambridge,Mass.), 106, 2001
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1LUZ
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![BU of 1luz by Molmil](/molmil-images/mine/1luz) | |
3ENP
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![BU of 3enp by Molmil](/molmil-images/mine/3enp) | Crystal structure of human cgi121 | Descriptor: | TP53RK-binding protein | Authors: | Haffani, Y.Z, Ceccarelli, D.F, Neculai, D, Mao, D.Y, Sicheri, F. | Deposit date: | 2008-09-25 | Release date: | 2008-11-04 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine. Mol.Cell, 32, 2008
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4PL5
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![BU of 4pl5 by Molmil](/molmil-images/mine/4pl5) | Crystal structure of murine IRE1 in complex with OICR573 inhibitor | Descriptor: | 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL, 3-methoxy-5-methyl-4'-(morpholin-4-yl)biphenyl-4-ol, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Sanches, M, Duffy, N, Talukdar, M, Thevakumaran, N, Chiovitti, D, Al-awar, R, Patterson, J.B, Sicheri, F. | Deposit date: | 2014-05-16 | Release date: | 2014-09-03 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors. Nat Commun, 5, 2014
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4PDP
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![BU of 4pdp by Molmil](/molmil-images/mine/4pdp) | |
4QLB
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![BU of 4qlb by Molmil](/molmil-images/mine/4qlb) | Structural Basis for the Recruitment of Glycogen Synthase by Glycogenin | Descriptor: | GLYCEROL, Probable glycogen [starch] synthase, Protein GYG-1, ... | Authors: | Zeqiraj, E, Judd, A, Sicheri, F. | Deposit date: | 2014-06-11 | Release date: | 2014-07-09 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis for the recruitment of glycogen synthase by glycogenin. Proc.Natl.Acad.Sci.USA, 111, 2014
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4PL4
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![BU of 4pl4 by Molmil](/molmil-images/mine/4pl4) | Crystal structure of murine IRE1 in complex with OICR464 inhibitor | Descriptor: | 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL, 2-methoxy-6-methyl-4-(4-methyl-3,4-dihydro-2H-1,4-benzoxazin-7-yl)phenol, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Sanches, M, Duffy, N, Talukdar, M, Thevakumaran, N, Chiovitti, D, Al-awar, R, Patterson, J.B, Sicheri, F. | Deposit date: | 2014-05-16 | Release date: | 2014-09-03 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors. Nat Commun, 5, 2014
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4PDS
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![BU of 4pds by Molmil](/molmil-images/mine/4pds) | Crystal structure of Rad53 kinase domain and SCD2 in complex with AMPPNP | Descriptor: | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase RAD53 | Authors: | Ho, C.S, Wybenga-Groot, L.E, Ceccarelli, D.F, Sicheri, F. | Deposit date: | 2014-04-21 | Release date: | 2014-05-28 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural basis of Rad53 kinase activation by dimerization and activation segment exchange. Cell Signal., 26, 2014
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7U3E
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![BU of 7u3e by Molmil](/molmil-images/mine/7u3e) | GID4 in complex with compound 1 | Descriptor: | Glucose-induced degradation protein 4 homolog, tert-butyl (1S,4S)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate | Authors: | Chana, C.K, Sicheri, F. | Deposit date: | 2022-02-27 | Release date: | 2022-10-05 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.852 Å) | Cite: | Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4. J.Med.Chem., 65, 2022
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7U3F
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![BU of 7u3f by Molmil](/molmil-images/mine/7u3f) | GID4 in complex with compound 4 | Descriptor: | (4R)-4-(4-methoxyphenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine, GLYCEROL, Glucose-induced degradation protein 4 homolog | Authors: | Chana, C.K, Sicheri, F. | Deposit date: | 2022-02-27 | Release date: | 2022-10-05 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4. J.Med.Chem., 65, 2022
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7U3H
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![BU of 7u3h by Molmil](/molmil-images/mine/7u3h) | GID4 in complex with compound 7 | Descriptor: | (5R)-N-(4-fluorophenyl)-5-methyl-4,5-dihydro-1,3-thiazol-2-amine, Glucose-induced degradation protein 4 homolog | Authors: | Chana, C.K, Sicheri, F. | Deposit date: | 2022-02-27 | Release date: | 2022-10-05 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.798 Å) | Cite: | Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4. J.Med.Chem., 65, 2022
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7U3L
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![BU of 7u3l by Molmil](/molmil-images/mine/7u3l) | GID4 in complex with compound 91 | Descriptor: | GLYCEROL, Glucose-induced degradation protein 4 homolog, Nalpha-{(2R,4E)-2-[(N-benzylglycyl)amino]-5-phenylpent-4-enoyl}-N,4-dimethyl-L-phenylalaninamide | Authors: | Chana, C.K, Sicheri, F. | Deposit date: | 2022-02-27 | Release date: | 2022-10-05 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.295 Å) | Cite: | Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4. J.Med.Chem., 65, 2022
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7U3G
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![BU of 7u3g by Molmil](/molmil-images/mine/7u3g) | GID4 in complex with compound 67 | Descriptor: | (1R)-1-phenyl-1,2,3,4-tetrahydroisoquinolin-5-amine, Glucose-induced degradation protein 4 homolog | Authors: | Chana, C.K, Sicheri, F. | Deposit date: | 2022-02-27 | Release date: | 2022-10-05 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.244 Å) | Cite: | Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4. J.Med.Chem., 65, 2022
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7U3K
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![BU of 7u3k by Molmil](/molmil-images/mine/7u3k) | GID4 in complex with compound 89 | Descriptor: | GLYCEROL, Glucose-induced degradation protein 4 homolog, N-butylglycyl-4-tert-butyl-D-phenylalanyl-3-methoxy-N-methyl-L-phenylalaninamide | Authors: | Chana, C.K, Sicheri, F. | Deposit date: | 2022-02-27 | Release date: | 2022-10-05 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.198 Å) | Cite: | Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4. J.Med.Chem., 65, 2022
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7U3I
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![BU of 7u3i by Molmil](/molmil-images/mine/7u3i) | GID4 in complex with compound 16 | Descriptor: | 3-{[(5S)-5-methyl-4,5-dihydro-1,3-thiazol-2-yl]amino}phenol, GLYCEROL, Glucose-induced degradation protein 4 homolog | Authors: | Chana, C.K, Sicheri, F. | Deposit date: | 2022-02-27 | Release date: | 2022-10-05 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.991 Å) | Cite: | Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4. J.Med.Chem., 65, 2022
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7U3J
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![BU of 7u3j by Molmil](/molmil-images/mine/7u3j) | GID4 in complex with compound 88 | Descriptor: | (2S)-2-{[(2S)-2-({N-[(2,4-dimethoxyphenyl)methyl]glycyl}amino)-2-(thiophen-2-yl)acetyl]amino}-N-methyl-4-phenylbutanamide, GLYCEROL, Glucose-induced degradation protein 4 homolog | Authors: | Chana, C.K, Sicheri, F. | Deposit date: | 2022-02-27 | Release date: | 2022-10-05 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.642 Å) | Cite: | Discovery and Structural Characterization of Small Molecule Binders of the Human CTLH E3 Ligase Subunit GID4. J.Med.Chem., 65, 2022
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4PL3
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![BU of 4pl3 by Molmil](/molmil-images/mine/4pl3) | Crystal structure of murine IRE1 in complex with MKC9989 inhibitor | Descriptor: | 7-hydroxy-6-methoxy-3-[2-(2-methoxyethoxy)ethyl]-4,8-dimethyl-2H-chromen-2-one, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Sanches, M, Duffy, N, Talukdar, M, Thevakumaran, N, Chiovitti, D, Al-awar, R, Patterson, J.B, Sicheri, F. | Deposit date: | 2014-05-16 | Release date: | 2014-09-03 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors. Nat Commun, 5, 2014
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3LJ1
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![BU of 3lj1 by Molmil](/molmil-images/mine/3lj1) | IRE1 complexed with Cdk1/2 Inhibitor III | Descriptor: | 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE, Serine/threonine-protein kinase/endoribonuclease IRE1 | Authors: | Lee, K.P.K, Sicheri, F. | Deposit date: | 2010-01-25 | Release date: | 2010-05-12 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.33 Å) | Cite: | Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1. Mol.Cell, 38, 2010
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3LJ0
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![BU of 3lj0 by Molmil](/molmil-images/mine/3lj0) | IRE1 complexed with ADP and Quercetin | Descriptor: | 3,5,7,3',4'-PENTAHYDROXYFLAVONE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Lee, K.P.K, Sicheri, F. | Deposit date: | 2010-01-25 | Release date: | 2010-05-12 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1. Mol.Cell, 38, 2010
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5TWF
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![BU of 5twf by Molmil](/molmil-images/mine/5twf) | |
5TWG
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![BU of 5twg by Molmil](/molmil-images/mine/5twg) | |
3MKS
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![BU of 3mks by Molmil](/molmil-images/mine/3mks) | Crystal Structure of yeast Cdc4/Skp1 in complex with an allosteric inhibitor SCF-I2 | Descriptor: | 1,1'-binaphthalene-2,2'-dicarboxylic acid, Cell division control protein 4, GLYCEROL, ... | Authors: | Orlicky, S, Sicheri, F, Tyers, M, Tang, X. | Deposit date: | 2010-04-15 | Release date: | 2010-07-21 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | An allosteric inhibitor of substrate recognition by the SCF(Cdc4) ubiquitin ligase. Nat.Biotechnol., 28, 2010
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