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5MCT
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BU of 5mct by Molmil
New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-LHG1)
Descriptor: 1,2-ETHANEDIOL, Cellular tumor antigen p53, DNA, ...
Authors:Golovenko, D, Rozenberg, H, Shakked, Z.
Deposit date:2016-11-10
Release date:2018-06-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.446 Å)
Cite:New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins.
Structure, 26, 2018
5MCU
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BU of 5mcu by Molmil
New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-LHG2)
Descriptor: 1,2-ETHANEDIOL, Cellular tumor antigen p53, DNA, ...
Authors:Golovenko, D, Rozenberg, H, Shakked, Z.
Deposit date:2016-11-10
Release date:2018-06-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins.
Structure, 26, 2018
3D08
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BU of 3d08 by Molmil
Human p53 core domain with hot spot mutation R249S and second-site suppressor mutation H168R
Descriptor: Cellular tumor antigen p53, ZINC ION
Authors:Suad, O, Rozenberg, H, Shimon, L.J.W, Frolow, F, Shakked, Z.
Deposit date:2008-05-01
Release date:2009-01-20
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations
J.Mol.Biol., 385, 2009
3D0A
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BU of 3d0a by Molmil
Human p53 core domain with hot spot mutation R249S and second site suppressor mutation H168R in sequence-specific complex with DNA
Descriptor: Cellular tumor antigen p53, DNA (5'-D(*DCP*DGP*DGP*DGP*DCP*DAP*DTP*DGP*DCP*DCP*DCP*DG)-3'), ZINC ION
Authors:Suad, O, Rozenberg, H, Shakked, Z.
Deposit date:2008-05-01
Release date:2009-01-20
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations
J.Mol.Biol., 385, 2009
3D07
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BU of 3d07 by Molmil
Human p53 core domain with hot spot mutation R249S (III)
Descriptor: Cellular tumor antigen p53, ZINC ION
Authors:Suad, O, Rozenberg, H, Shakked, Z.
Deposit date:2008-05-01
Release date:2009-01-20
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations
J.Mol.Biol., 385, 2009
3D06
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BU of 3d06 by Molmil
Human p53 core domain with hot spot mutation R249S (I)
Descriptor: Cellular tumor antigen p53, ZINC ION
Authors:Rozenberg, H, Suad, O, Shimon, L.J.W, Frolow, F, Shakked, Z.
Deposit date:2008-05-01
Release date:2009-01-20
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations
J.Mol.Biol., 385, 2009
3D09
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BU of 3d09 by Molmil
Human p53 core domain with hot spot mutation R249S and second-site suppressor mutations H168R and T123A
Descriptor: Cellular tumor antigen p53, ZINC ION
Authors:Rozenberg, H, Suad, O, Shakked, Z.
Deposit date:2008-05-01
Release date:2009-01-20
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations
J.Mol.Biol., 385, 2009
3D05
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BU of 3d05 by Molmil
Human p53 core domain with hot spot mutation R249S (II)
Descriptor: Cellular tumor antigen p53, ZINC ION
Authors:Suad, O, Rozenberg, H, Shimon, L.J.W, Frolow, F, Shakked, Z.
Deposit date:2008-05-01
Release date:2009-01-20
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations
J.Mol.Biol., 385, 2009
1VT9
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BU of 1vt9 by Molmil
The structure and hydration of the A-DNA fragment D(GGGTACCC) at room temperature and low temperature
Descriptor: DNA (5'-D(*GP*GP*GP*TP*AP*CP*CP*C)-3')
Authors:Eisenstein, M, Frolow, F, Shakked, Z, Rabinovich, D.
Deposit date:1991-04-11
Release date:2011-07-13
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The structure and hydration of the A-DNA fragment d(GGGTACCC) at room temperature and low temperature.
Nucleic Acids Res., 18, 1990
1VT5
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BU of 1vt5 by Molmil
THE CRYSTAL STRUCTURE OF D(CCCCGGGG): A NEW A-FORM VARIANT WITH AN EXTENDED BACKBONE CONFORMATION
Descriptor: DNA (5'-D(*CP*CP*CP*CP*GP*GP*GP*G)-3')
Authors:Haran, T.E, Shakked, Z, Wang, A.H.-J, Rich, A.
Deposit date:1988-08-18
Release date:2011-07-13
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:The crystal structure of d(CCCCGGGG): a new A-form variant with an extended backbone conformation.
J.Biomol.Struct.Dyn., 5, 1987
1VTA
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BU of 1vta by Molmil
THE STRUCTURE AND HYDRATION OF THE A-DNA FRAGMENT D(GGGTACCC) AT ROOM TEMPERATURE AND LOW TEMPERATURE
Descriptor: DNA (5'-D(*GP*GP*GP*TP*AP*CP*CP*C)-3')
Authors:Eisenstein, M, Frolow, F, Shakked, Z, Rabinovich, D.
Deposit date:1991-04-11
Release date:2011-07-13
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The structure and hydration of the A-DNA fragment d(GGGTACCC) at room temperature and low temperature.
Nucleic Acids Res., 18, 1990
1VT7
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BU of 1vt7 by Molmil
Structures of the mismatched duplex D(GGGTGCCC)
Descriptor: DNA (5'-D(*GP*GP*GP*TP*GP*CP*CP*C)-3')
Authors:Rabinovich, D, Haran, T, Eisenstein, M, Shakked, Z.
Deposit date:1996-12-02
Release date:2011-07-13
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of the mismatched duplex d(GGGTGCCC) and one of its Watson-Crick analogues d(GGGCGCCC).
J.Mol.Biol., 200, 1988
1XJY
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BU of 1xjy by Molmil
The crystal structures of the DNA binding sites of the RUNX1 transcription factor
Descriptor: 5'-D(*TP*CP*TP*GP*CP*GP*GP*TP*C)-3', 5'-D(*TP*GP*AP*CP*CP*GP*CP*AP*G)-3'
Authors:Kitayner, M, Rozenberg, H, Rabinovich, D, Shakked, Z.
Deposit date:2004-09-26
Release date:2005-03-15
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of the DNA-binding site of Runt-domain transcription regulators.
Acta Crystallogr.,Sect.D, 61, 2005
1XJX
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BU of 1xjx by Molmil
The crystal structures of the DNA binding sites of the RUNX1 transcription factor
Descriptor: 5'-D(*TP*CP*TP*GP*CP*GP*GP*TP*C)-3', 5'-D(*TP*GP*AP*CP*CP*GP*CP*AP*G)-3'
Authors:Kitayner, M, Rozenberg, H, Rabinovich, D, Shakked, Z.
Deposit date:2004-09-26
Release date:2005-03-15
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structures of the DNA-binding site of Runt-domain transcription regulators.
Acta Crystallogr.,Sect.D, 61, 2005
2ATA
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BU of 2ata by Molmil
Structural Basis of DNA Recognition by p53 Tetramers (complex II)
Descriptor: 5'-D(*AP*AP*GP*GP*CP*AP*TP*GP*CP*CP*TP*T)-3', Cellular tumor antigen p53, ZINC ION
Authors:Kitayner, M, Rozenberg, H, Kessler, N, Rabinovich, D, Shakked, Z.
Deposit date:2005-08-24
Release date:2006-07-11
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Basis of DNA Recognition by p53 Tetramers
Mol.Cell, 22, 2006
2AHI
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BU of 2ahi by Molmil
Structural Basis of DNA Recognition by p53 Tetramers (complex III)
Descriptor: 5'-D(*CP*GP*GP*AP*CP*AP*TP*GP*TP*CP*CP*G)-3', Cellular tumor antigen p53, ZINC ION
Authors:Kitayner, M, Rozenberg, H, Kessler, N, Rabinovich, D, Shakked, Z.
Deposit date:2005-07-28
Release date:2006-07-11
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural Basis of DNA Recognition by p53 Tetramers
Mol.Cell, 22, 2006
2ADY
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BU of 2ady by Molmil
Structural Basis of DNA Recognition by p53 Tetramers (complex IV)
Descriptor: 5'-D(*CP*GP*GP*AP*CP*AP*TP*GP*TP*CP*CP*G)-3', Cellular tumor antigen p53, ZINC ION
Authors:Kitayner, M, Rozenberg, H, Kessler, N, Rabinovich, D, Shakked, Z.
Deposit date:2005-07-21
Release date:2006-07-11
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis of DNA Recognition by p53 Tetramers
Mol.Cell, 22, 2006
287D
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BU of 287d by Molmil
X-RAY AND SOLUTION STUDIES OF DNA OLIGOMERS AND IMPLICATIONS FOR THE STRUCTURAL BASIS OF A-TRACT-DEPENDENT CURVATURE
Descriptor: DNA (5'-D(*CP*GP*CP*GP*AP*TP*AP*TP*CP*GP*CP*G)-3')
Authors:Eisenstein, M, Shatzky-Schwartz, M, Shakked, Z.
Deposit date:1996-09-20
Release date:1997-05-08
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:X-ray and solution studies of DNA oligomers and implications for the structural basis of A-tract-dependent curvature.
J.Mol.Biol., 267, 1997
286D
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BU of 286d by Molmil
X-RAY AND SOLUTION STUDIES OF DNA OLIGOMERS AND IMPLICATIONS FOR THE STRUCTURAL BASIS OF A-TRACT-DEPENDENT CURVATURE
Descriptor: DNA (5'-D(*CP*CP*IP*IP*IP*CP*CP*CP*GP*G)-3')
Authors:Shatzky-Schwartz, M, Shakked, Z, Luisi, B.F.
Deposit date:1996-09-16
Release date:1997-05-08
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:X-ray and solution studies of DNA oligomers and implications for the structural basis of A-tract-dependent curvature.
J.Mol.Biol., 267, 1997
2AC0
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BU of 2ac0 by Molmil
Structural Basis of DNA Recognition by p53 Tetramers (complex I)
Descriptor: 5'-D(*CP*GP*GP*GP*CP*AP*TP*GP*CP*CP*CP*G)-3', Cellular tumor antigen p53, ZINC ION
Authors:Kitayner, M, Rozenberg, H, Kessler, N, Rabinovich, D, Shakked, Z.
Deposit date:2005-07-18
Release date:2006-07-11
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis of DNA Recognition by p53 Tetramers
Mol.Cell, 22, 2006
285D
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BU of 285d by Molmil
X-RAY AND SOLUTION STUDIES OF DNA OLIGOMERS AND IMPLICATIONS FOR THE STRUCTURAL BASIS OF A-TRACT-DEPENDENT CURVATURE
Descriptor: DNA (5'-D(*CP*GP*CP*AP*IP*AP*TP*(5CM)P*TP*GP*CP*G)-3')
Authors:Shatzky-Schwartz, M, Shakked, Z, Luisi, B.F.
Deposit date:1996-09-11
Release date:1997-05-08
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:X-ray and solution studies of DNA oligomers and implications for the structural basis of A-tract-dependent curvature.
J.Mol.Biol., 267, 1997
6ZNC
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BU of 6znc by Molmil
Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human wild-type p53DBD bound to DNA and MQ: wt-DNA-MQ (I)
Descriptor: (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, Cellular tumor antigen p53, ...
Authors:Rozenberg, H, Degtjarik, O, Diskin-Posner, Y, Shakked, Z.
Deposit date:2020-07-06
Release date:2021-12-08
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ).
Nat Commun, 12, 2021
7B4D
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BU of 7b4d by Molmil
Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273C/S240R double mutant bound to DNA and MQ: R273C/S240R-DNA-MQ
Descriptor: (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, Cellular tumor antigen p53, ...
Authors:Rozenberg, H, Diskin-Posner, Y, Degtjarik, O, Shakked, Z.
Deposit date:2020-12-02
Release date:2021-12-08
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ).
Nat Commun, 12, 2021
7B4N
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BU of 7b4n by Molmil
Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human wild-type p53DBD bound to DNA and MQ: wt-DNA-MQ (II)
Descriptor: (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, Cellular tumor antigen p53, ...
Authors:Rozenberg, H, Diskin-Posner, Y, Degtjarik, O, Shakked, Z.
Deposit date:2020-12-02
Release date:2021-12-08
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ).
Nat Commun, 12, 2021
7B49
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BU of 7b49 by Molmil
Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to DNA and MQ: R273H-DNA-MQ
Descriptor: (2~{R})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, (2~{S})-2-methyl-1-azabicyclo[2.2.2]octan-3-one, 1,2-ETHANEDIOL, ...
Authors:Rozenberg, H, Degtjarik, O, Shakked, Z.
Deposit date:2020-12-02
Release date:2021-12-08
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ).
Nat Commun, 12, 2021

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