5OI9
 
 | | Trichoplax adhaerens STIL N-terminal domain | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Putative uncharacterized protein | | Authors: | van Breugel, M. | | Deposit date: | 2017-07-18 | | Release date: | 2018-04-18 | | Last modified: | 2018-05-09 | | Method: | X-RAY DIFFRACTION (2.09 Å) | | Cite: | Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly.
Nat Commun, 9, 2018
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5OI7
 | | Human CEP85 - coiled coil domain 4 | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Centrosomal protein of 85 kDa | | Authors: | van Breugel, M. | | Deposit date: | 2017-07-18 | | Release date: | 2018-04-18 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.67 Å) | | Cite: | Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly.
Nat Commun, 9, 2018
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5OID
 | | Complex Trichoplax STIL-NTD:human CEP85 coiled coil domain 4 | | Descriptor: | Centrosomal protein of 85 kDa, Putative uncharacterized protein | | Authors: | van Breugel, M. | | Deposit date: | 2017-07-18 | | Release date: | 2018-04-18 | | Last modified: | 2018-05-09 | | Method: | X-RAY DIFFRACTION (4.6 Å) | | Cite: | Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly.
Nat Commun, 9, 2018
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5OLM
 | | TRIM21 | | Descriptor: | E3 ubiquitin-protein ligase TRIM21, ZINC ION | | Authors: | James, L.C. | | Deposit date: | 2017-07-28 | | Release date: | 2018-04-25 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21.
Elife, 7, 2018
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6I7G
 | | Crystal structure of dimeric wild type FICD complexed with ATP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Adenosine monophosphate-protein transferase FICD, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Perera, L.A, Yan, Y, Read, R.J, Ron, D. | | Deposit date: | 2018-11-16 | | Release date: | 2019-09-25 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | An oligomeric state-dependent switch in the ER enzyme FICD regulates AMPylation and deAMPylation of BiP.
Embo J., 38, 2019
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6I7L
 | | Crystal structure of monomeric FICD mutant L258D complexed with MgAMP-PNP | | Descriptor: | Adenosine monophosphate-protein transferase FICD, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Perera, L.A, Yan, Y, Read, R.J, Ron, D. | | Deposit date: | 2018-11-16 | | Release date: | 2019-09-25 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.32 Å) | | Cite: | An oligomeric state-dependent switch in the ER enzyme FICD regulates AMPylation and deAMPylation of BiP.
Embo J., 38, 2019
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4D0L
 | | Phosphatidylinositol 4-kinase III beta-PIK93 in a complex with Rab11a- GTP gammaS | | Descriptor: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDE, ... | | Authors: | Burke, J.E, Inglis, A.J, Perisic, O, Masson, G.R, McLaughin, S.H, Rutaganira, F, Shokat, K.M, Williams, R.L. | | Deposit date: | 2014-04-29 | | Release date: | 2014-05-28 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.94 Å) | | Cite: | Structures of Pi4Kiiibeta Complexes Show Simultaneous Recruitment of Rab11 and its Effectors.
Science, 344, 2014
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4X2O
 | | Sac3N peptide bound to Mex67:Mtr2 | | Descriptor: | Putative SAC3 family protein, Putative mRNA export protein, Putative uncharacterized protein | | Authors: | Aibara, S, Valkov, E, Stewart, M. | | Deposit date: | 2014-11-26 | | Release date: | 2015-06-17 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structural Characterization of the Chaetomium thermophilum TREX-2 Complex and its Interaction with the mRNA Nuclear Export Factor Mex67:Mtr2.
Structure, 23, 2015
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4WPX
 | | Chaetomium theromophilum TREX2 CID domain complex | | Descriptor: | Cell division control protein 31-like protein, Putative SAC3 family protein, Putative uncharacterized protein | | Authors: | Valkov, E, Stewart, M. | | Deposit date: | 2014-10-21 | | Release date: | 2015-06-17 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (3.31 Å) | | Cite: | Structural Characterization of the Chaetomium thermophilum TREX-2 Complex and its Interaction with the mRNA Nuclear Export Factor Mex67:Mtr2.
Structure, 23, 2015
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4X2H
 | | Sac3N peptide bound to Mex67:Mtr2 | | Descriptor: | Putative mRNA export protein, Putative uncharacterized protein, SER-SER-VAL-PHE-GLY-ALA-PRO-ALA | | Authors: | Aibara, S, Valkov, E, Stewart, M. | | Deposit date: | 2014-11-26 | | Release date: | 2015-06-17 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural Characterization of the Chaetomium thermophilum TREX-2 Complex and its Interaction with the mRNA Nuclear Export Factor Mex67:Mtr2.
Structure, 23, 2015
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3CFS
 | | Structural basis of the interaction of RbAp46/RbAp48 with histone H4 | | Descriptor: | ARSENIC, Histone H4, Histone-binding protein RBBP7 | | Authors: | Murzina, N.V, Pei, X.-Y, Pratap, J.V, Sparkes, M, Vicente-Garcia, J, Ben-Shahar, T.R, Verreault, A, Luisi, B.F, Laue, E.D. | | Deposit date: | 2008-03-04 | | Release date: | 2008-06-10 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural Basis for the Recognition of Histone H4 by the Histone-Chaperone RbAp46.
Structure, 16, 2008
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7B1H
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7B1F
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7B1J
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7PB8
 | | Crystal structure of the CENP-OPQUR complex | | Descriptor: | Centromere protein O, Centromere protein P, Centromere protein Q, ... | | Authors: | Bellini, D, Yatskevich, S, Muir, K.W, Barford, D. | | Deposit date: | 2021-07-31 | | Release date: | 2022-04-27 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (3.68 Å) | | Cite: | Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome.
Science, 376, 2022
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7PB4
 | | Cenp-HIK 3-protein complex | | Descriptor: | Centromere protein H, Centromere protein I, Centromere protein K | | Authors: | Bellini, D, Yatskevich, S, Muir, W.K, Barford, D. | | Deposit date: | 2021-07-30 | | Release date: | 2022-04-27 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.49 Å) | | Cite: | Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome.
Science, 376, 2022
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7PKN
 | | Structure of the human CCAN deltaCT complex | | Descriptor: | Centromere protein H, Centromere protein I, Centromere protein K, ... | | Authors: | Muir, K.W, Yatskevich, S, Bellini, D, Barford, D. | | Deposit date: | 2021-08-25 | | Release date: | 2022-04-27 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome.
Science, 376, 2022
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7PII
 | | Structure of the human CCAN CENP-A alpha-satellite complex | | Descriptor: | Centromere protein C, DNA (122-MER), DNA (123-MER), ... | | Authors: | Yatskevich, S, Muir, K.W, Bellini, D, Barford, D. | | Deposit date: | 2021-08-19 | | Release date: | 2022-05-25 | | Last modified: | 2024-07-17 | | Method: | ELECTRON MICROSCOPY (2.68 Å) | | Cite: | Structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome.
Science, 376, 2022
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7PG5
 | | Crystal Structure of PI3Kalpha | | Descriptor: | GLYCEROL, PHOSPHATE ION, Phosphatidylinositol 3-kinase regulatory subunit alpha, ... | | Authors: | Gong, G, Pinotsis, N, Williams, R.L, Vanhaesebroeck, B. | | Deposit date: | 2021-08-13 | | Release date: | 2022-08-24 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.20029068 Å) | | Cite: | A small-molecule PI3K alpha activator for cardioprotection and neuroregeneration.
Nature, 618, 2023
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7PG6
 | | Crystal Structure of PI3Kalpha in complex with the inhibitor NVP-BYL719 | | Descriptor: | (2S)-N~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, ... | | Authors: | Gong, G, Pinotsis, N, Williams, R.L, Vanhaesebroeck, B. | | Deposit date: | 2021-08-13 | | Release date: | 2022-08-24 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.49943733 Å) | | Cite: | A small-molecule PI3K alpha activator for cardioprotection and neuroregeneration.
Nature, 618, 2023
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5L2L
 | | Nab2 Zn fingers 5-7 bound to A11G RNA | | Descriptor: | Nab2p, RNA (5'-R(*AP*AP*AP*AP*AP*AP*AP*AP*AP*G)-3'), ZINC ION | | Authors: | Stewart, M, Aibara, S. | | Deposit date: | 2016-08-02 | | Release date: | 2016-12-21 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Structural basis for the dimerization of Nab2 generated by RNA binding provides insight into its contribution to both poly(A) tail length determination and transcript compaction in Saccharomyces cerevisiae.
Nucleic Acids Res., 45, 2017
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5LJM
 | | Structure of SPATA2 PUB domain | | Descriptor: | GLYCEROL, Spermatogenesis-associated protein 2 | | Authors: | Elliott, P.R, Komander, D. | | Deposit date: | 2016-07-18 | | Release date: | 2016-08-24 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.454 Å) | | Cite: | SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling.
Mol.Cell, 63, 2016
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5LPI
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5LPH
 | | Structure of the TOG domain of human Cep104 | | Descriptor: | Centrosomal protein of 104 kDa | | Authors: | van Breugel, M. | | Deposit date: | 2016-08-13 | | Release date: | 2017-01-11 | | Last modified: | 2017-09-13 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | The Ciliopathy-Associated Cep104 Protein Interacts with Tubulin and Nek1 Kinase.
Structure, 25, 2017
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5LY5
 | | Arcadin-1 from Pyrobaculum calidifontis | | Descriptor: | arcadin-1 | | Authors: | Izore, T, Lowe, J. | | Deposit date: | 2016-09-23 | | Release date: | 2017-01-18 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crenactin forms actin-like double helical filaments regulated by arcadin-2.
Elife, 5, 2016
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