Human CEP85 - coiled coil domain 4

Summary for 5OI7

DescriptorCentrosomal protein of 85 kDa, (4S)-2-METHYL-2,4-PENTANEDIOL (3 entities in total)
Functional Keywordscentrosomes, centriole, cep85, stil, protein binding
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm, cytoskeleton, microtubule organizing center, centrosome  Q6P2H3
Total number of polymer chains2
Total molecular weight20813.04
van Breugel, M. (deposition date: 2017-07-18, release date: 2018-04-18, Last modification date: 2018-05-09)
Primary citation
Liu, Y.,Gupta, G.D.,Barnabas, D.D.,Agircan, F.G.,Mehmood, S.,Wu, D.,Coyaud, E.,Johnson, C.M.,McLaughlin, S.H.,Andreeva, A.,Freund, S.M.V.,Robinson, C.V.,Cheung, S.W.T.,Raught, B.,Pelletier, L.,van Breugel, M.
Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly.
Nat Commun, 9:1731-1731, 2018
PubMed: 29712910 (PDB entries with the same primary citation)
DOI: 10.1038/s41467-018-04122-x
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2413000.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution