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4U3V
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BU of 4u3v by Molmil
Crystal structure of the trans-acyltransferase polyketide synthase enoyl-isomerase
Descriptor: Polyketide synthase PksR
Authors:Gay, D.C, Spear, P.J, Keatinge-Clay, A.T.
Deposit date:2014-07-22
Release date:2014-08-20
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:A Double-Hotdog with a New Trick: Structure and Mechanism of the trans-Acyltransferase Polyketide Synthase Enoyl-isomerase.
Acs Chem.Biol., 9, 2014
5E5N
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BU of 5e5n by Molmil
Ketosynthase from module 6 of the bacillaene synthase from Bacillus subtilis 168 (C167S mutant, crystal form 1)
Descriptor: Polyketide synthase PksL
Authors:Wagner, D.T, Gay, D.C, Keatinge-Clay, A.T.
Deposit date:2015-10-08
Release date:2015-11-18
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:The LINKS motif zippers trans-acyltransferase polyketide synthase assembly lines into a biosynthetic megacomplex.
J.Struct.Biol., 193, 2016
5E6K
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BU of 5e6k by Molmil
Ketosynthase from module 6 of the bacillaene synthase from Bacillus subtilis 168 (C167S mutant, crystal form 2)
Descriptor: Polyketide synthase PksL, SULFATE ION
Authors:Wagner, D.T, Gay, D.C, Keatinge-Clay, A.T.
Deposit date:2015-10-10
Release date:2015-11-18
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:The LINKS motif zippers trans-acyltransferase polyketide synthase assembly lines into a biosynthetic megacomplex.
J.Struct.Biol., 193, 2016
3MJV
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BU of 3mjv by Molmil
Structure of A-type Ketoreductases from Modular Polyketide Synthase
Descriptor: AmphB, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Zheng, J, Taylor, C.A, Piasecki, S.K, Keatinge-Clay, A.T.
Deposit date:2010-04-13
Release date:2010-08-18
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Structural and Functional Analysis of A-Type Ketoreductases from the Amphotericin Modular Polyketide Synthase.
Structure, 18, 2010
3MJE
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BU of 3mje by Molmil
Structure of A-type Ketoreductases from Modular Polyketide Synthase
Descriptor: AmphB, GLYCEROL, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Zheng, J, Taylor, C.A, Piasecki, S.K, Keatinge-Clay, A.T.
Deposit date:2010-04-12
Release date:2010-08-18
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:Structural and Functional Analysis of A-Type Ketoreductases from the Amphotericin Modular Polyketide Synthase.
Structure, 18, 2010
5ELP
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BU of 5elp by Molmil
Ketosynthase from module 1 of the bacillaene synthase from Bacillus amyloliquefaciens FZB42
Descriptor: NRPS/PKS protein
Authors:Wagner, D.T, Gay, D.C, Keatinge-Clay, A.T, Zogzas, C.E.
Deposit date:2015-11-04
Release date:2016-01-13
Last modified:2016-11-02
Method:X-RAY DIFFRACTION (2.93 Å)
Cite:The LINKS motif zippers trans-acyltransferase polyketide synthase assembly lines into a biosynthetic megacomplex.
J.Struct.Biol., 193, 2016
5ERB
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BU of 5erb by Molmil
Ketosynthase from module 5 of the bacillaene synthase from Bacillus amyloliquefaciens FZB42
Descriptor: Polyketide synthase
Authors:Wagner, D.T, Gay, D.C, Keatinge-Clay, A.T, Meinke, J.
Deposit date:2015-11-13
Release date:2015-12-23
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:The LINKS motif zippers trans-acyltransferase polyketide synthase assembly lines into a biosynthetic megacomplex.
J.Struct.Biol., 193, 2016
5ERF
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BU of 5erf by Molmil
Ketosynthase from module 6 of the bacillaene synthase from Bacillus subtilis 168
Descriptor: Polyketide synthase PksL
Authors:Wagner, D.T, Gay, D.C, Keatinge-Clay, A.T.
Deposit date:2015-11-14
Release date:2015-12-23
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The LINKS motif zippers trans-acyltransferase polyketide synthase assembly lines into a biosynthetic megacomplex.
J.Struct.Biol., 193, 2016
5ENY
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BU of 5eny by Molmil
Ketosynthase from module 6 connected to acyl carrier protein from module 5 (unobservable) of the bacillaene synthase from Bacillus subtilis 168
Descriptor: Polyketide synthase PksL
Authors:Wagner, D.T, Gay, D.C, Keatinge-Clay, A.T.
Deposit date:2015-11-09
Release date:2015-12-23
Last modified:2016-11-02
Method:X-RAY DIFFRACTION (4 Å)
Cite:The LINKS motif zippers trans-acyltransferase polyketide synthase assembly lines into a biosynthetic megacomplex.
J.Struct.Biol., 193, 2016
6CCA
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BU of 6cca by Molmil
Crystal structure of DszA carbon methyltransferase
Descriptor: DisA protein
Authors:Meinke, J.L, Keatinge-Clay, A.T.
Deposit date:2018-02-06
Release date:2018-12-05
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural and Functional Studies of a gem-Dimethylating Methyltransferase from a trans-Acyltransferase Assembly Line.
ACS Chem. Biol., 13, 2018
3QP9
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BU of 3qp9 by Molmil
The Structure of a C2-type Ketoreductase from a Modular Polyketide Synthase
Descriptor: Type I polyketide synthase PikAII
Authors:Zheng, J, Keatinge-Clay, A.T.
Deposit date:2011-02-11
Release date:2011-05-11
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Structural and functional analysis of c2-type ketoreductases from modular polyketide synthases.
J.Mol.Biol., 410, 2011
6B2V
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BU of 6b2v by Molmil
Pyran synthase domain from module nine of the sorangicin pathway
Descriptor: SorB
Authors:Wagner, D.T, Keatinge-Clay, A.T.
Deposit date:2017-09-20
Release date:2018-04-18
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural and Functional Studies of a Pyran Synthase Domain from a trans-Acyltransferase Assembly Line.
ACS Chem. Biol., 13, 2018
3TSA
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BU of 3tsa by Molmil
Spinosyn Rhamnosyltransferase SpnG
Descriptor: MAGNESIUM ION, NDP-rhamnosyltransferase, alpha-D-glucopyranose
Authors:Isiorho, E.A, Liu, H.-W, Keatinge-Clay, A.T.
Deposit date:2011-09-12
Release date:2012-02-15
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Studies of the Spinosyn Rhamnosyltransferase, SpnG.
Biochemistry, 51, 2012
3SLK
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BU of 3slk by Molmil
Structure of ketoreductase and enoylreductase didomain from modular polyketide synthase
Descriptor: NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Polyketide synthase extender module 2, SULFATE ION
Authors:Zheng, J, Gay, D.C, Keatinge-Clay, A.T.
Deposit date:2011-06-24
Release date:2012-05-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3 Å)
Cite:Divergence of multimodular polyketide synthases revealed by a didomain structure.
Nat.Chem.Biol., 8, 2012
3UYK
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BU of 3uyk by Molmil
Spinosyn Rhamnosyltransferase SpnG complexed with spinosyn aglycone
Descriptor: (2R,3aS,5aR,5bS,9S,13S,14R,16aS,16bR)-9-ethyl-2,13-dihydroxy-14-methyl-2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b-tetradecahydro-1H-as-indaceno[3,2-d]oxacyclododecine-7,15-dione, MAGNESIUM ION, NDP-rhamnosyltransferase, ...
Authors:Isiorho, E.A, Liu, H.-W, Keatinge-Clay, A.T.
Deposit date:2011-12-06
Release date:2012-02-15
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Studies of the Spinosyn Rhamnosyltransferase, SpnG.
Biochemistry, 51, 2012
3UYL
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BU of 3uyl by Molmil
Spinosyn Rhamnosyltransferase SpnG complexed with thymidine diphosphate
Descriptor: MAGNESIUM ION, NDP-rhamnosyltransferase, THYMIDINE-5'-DIPHOSPHATE, ...
Authors:Isiorho, E.A, Liu, H.-W, Keatinge-Clay, A.T.
Deposit date:2011-12-06
Release date:2012-02-15
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural Studies of the Spinosyn Rhamnosyltransferase, SpnG.
Biochemistry, 51, 2012
4L4X
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BU of 4l4x by Molmil
An A2-type ketoreductase from a modular polyketide synthase
Descriptor: AmphI, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Zheng, J, Keatinge-Clay, A.T.
Deposit date:2013-06-10
Release date:2013-06-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural Studies of an A2-Type Modular Polyketide Synthase Ketoreductase Reveal Features Controlling alpha-Substituent Stereochemistry.
Acs Chem.Biol., 8, 2013
4NA3
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BU of 4na3 by Molmil
Crystal Structure of the second ketosynthase from the bacillaene polyketide synthase bound to a hexanoyl substrate mimic
Descriptor: Polyketide synthase PksJ, SULFATE ION
Authors:Gay, D.C, Gay, G.R, Keatinge-Clay, A.T.
Deposit date:2013-10-21
Release date:2014-02-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:A close look at a ketosynthase from a trans-acyltransferase modular polyketide synthase.
Structure, 22, 2014
4NA2
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BU of 4na2 by Molmil
Crystal Structure of the second ketosynthase from the bacillaene polyketide synthase bound to its natural intermediate
Descriptor: Polyketide synthase PksJ
Authors:Gay, D.C, Gay, G.R, Keatinge-Clay, A.T.
Deposit date:2013-10-21
Release date:2014-02-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A close look at a ketosynthase from a trans-acyltransferase modular polyketide synthase.
Structure, 22, 2014
4NA1
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BU of 4na1 by Molmil
Crystal Structure of the second ketosynthase from the bacillaene polyketide synthase
Descriptor: Polyketide synthase PksJ, SULFATE ION
Authors:Gay, D.C, Gay, G.R, Keatinge-Clay, A.T.
Deposit date:2013-10-21
Release date:2014-02-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A close look at a ketosynthase from a trans-acyltransferase modular polyketide synthase.
Structure, 22, 2014
4OXI
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BU of 4oxi by Molmil
Crystal structure of Vibrio cholerae adenylation domain AlmE in complex with glycyl-adenosine-5'-phosphate
Descriptor: Enterobactin synthetase component F-related protein, GLYCYL-ADENOSINE-5'-PHOSPHATE
Authors:Fage, C.D, Henderson, J.C, Keatinge-Clay, A.T, Trent, M.S.
Deposit date:2014-02-05
Release date:2014-12-31
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.261 Å)
Cite:Antimicrobial peptide resistance of Vibrio cholerae results from an LPS modification pathway related to nonribosomal peptide synthetases.
Acs Chem.Biol., 9, 2014
3EL6
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BU of 3el6 by Molmil
Crystal Structure of the Erythromycin Dehydratase
Descriptor: CHLORIDE ION, Erythromycin dehydratase, SULFATE ION
Authors:Keatinge-Clay, A.T.
Deposit date:2008-09-20
Release date:2008-11-11
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of the erythromycin polyketide synthase dehydratase.
J.Mol.Biol., 384, 2008
1MZJ
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BU of 1mzj by Molmil
Crystal Structure of the Priming beta-Ketosynthase from the R1128 Polyketide Biosynthetic Pathway
Descriptor: ACETYL GROUP, Beta-ketoacylsynthase III, COENZYME A
Authors:Pan, H, Tsai, S.C, Meadows, E.S, Miercke, L.J.W, Keatinge-Clay, A, O'Connell, J, Khosla, C, Stroud, R.M.
Deposit date:2002-10-08
Release date:2002-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the priming beta-ketosynthase from the R1128 polyketide biosynthetic pathway
Structure, 10
5XWV
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BU of 5xwv by Molmil
Substrate-bound Structure of a Ketoreductase from the Second Module of the amphotericin Polyketide Synthases
Descriptor: AmphB, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, S-[2-[3-[[(2R)-3,3-dimethyl-2,4-bis(oxidanyl)butanoyl]amino]propanoylamino]ethyl] (2R)-2-methyl-3-oxidanylidene-pentanethioate
Authors:Liu, C, Zheng, J.
Deposit date:2017-06-30
Release date:2018-06-06
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Substrate-bound structures of a ketoreductase from amphotericin modular polyketide synthase.
J. Struct. Biol., 203, 2018
5XWW
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BU of 5xww by Molmil
Substrate-bound Structure of G355T/Q364H mutant of a Ketoreductase from amphotericin Polyketide Synthases
Descriptor: AmphB, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, S-[2-[3-[[(2R)-3,3-dimethyl-2,4-bis(oxidanyl)butanoyl]amino]propanoylamino]ethyl] (2R)-2-methyl-3-oxidanylidene-pentanethioate
Authors:Liu, C, Zheng, J.
Deposit date:2017-06-30
Release date:2018-06-06
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Substrate-bound structures of a ketoreductase from amphotericin modular polyketide synthase.
J. Struct. Biol., 203, 2018

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