5XWW

Substrate-bound Structure of G355T/Q364H mutant of a Ketoreductase from amphotericin Polyketide Synthases

Summary for 5XWW

• Entry DOI: 10.2210/pdb5xww/pdb
• Descriptor: AmphB, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, S-[2-[3-[[(2R)-3,3-dimethyl-2,4-bis(oxidanyl)butanoyl]amino]propanoylamino]ethyl] (2R)-2-methyl-3-oxidanylidene-pentanethioate, ... (4 entities in total)
• Functional Keywords: modular polyketide synthease, ketoreductase, mutant, oxidoreductase
• Biological source: Streptomyces nodosus
• Total number of polymer chains: 2
• Total formula weight: 105225.33

Authors

Liu, C.,Zheng, J. (deposition date: 2017-06-30, release date: 2018-06-06, Last modification date: 2023-11-22)

• Primary citation: Liu, C.,Yuan, M.,Xu, X.,Wang, L.,Keatinge-Clay, A.T.,Deng, Z.,Lin, S.,Zheng, J.; Substrate-bound structures of a ketoreductase from amphotericin modular polyketide synthase.; J. Struct. Biol., 203:135-141, 2018; PubMed: 29626512; DOI: 10.1016/j.jsb.2018.04.001

Experimental method

X-RAY DIFFRACTION (1.96 Å)