7QEE
 
 | | SN243 mutant D415N bound to para-nitrophenyl-Beta-D-glucuronide | | Descriptor: | 4-nitrophenyl beta-D-glucopyranosiduronic acid, SN243, SULFATE ION, ... | | Authors: | Neun, S, Brear, P, Campbell, E, Omari, K, Wagner, O, Hyvonen, M, Hollfelder, F. | | Deposit date: | 2021-12-02 | | Release date: | 2022-11-16 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.374 Å) | | Cite: | Functional metagenomic screening identifies an unexpected beta-glucuronidase.
Nat.Chem.Biol., 18, 2022
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7QEF
 | | Crystal structure of para-nitrophenyl-Beta-D-glucuronide bound to a mutant of SN243 (D415A) | | Descriptor: | 4-nitrophenyl beta-D-glucopyranosiduronic acid, ACETATE ION, SN243, ... | | Authors: | Neun, S, Brear, P, Campbell, E, Omari, K, Wagner, O, Hyvonen, M, Hollfelder, F. | | Deposit date: | 2021-12-02 | | Release date: | 2022-10-12 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.41 Å) | | Cite: | Functional metagenomic screening identifies an unexpected beta-glucuronidase.
Nat.Chem.Biol., 18, 2022
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7QE2
 | | Crystal structure of D-glucuronic acid bound to SN243 | | Descriptor: | ACETATE ION, SN243, SULFATE ION, ... | | Authors: | Neun, S, Brear, P, Campbell, E, Omari, K, Wagner, O, Hyvonen, M, Hollfelder, F. | | Deposit date: | 2021-12-01 | | Release date: | 2022-10-12 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Functional metagenomic screening identifies an unexpected beta-glucuronidase.
Nat.Chem.Biol., 18, 2022
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7QE1
 | | Crystal structure of apo SN243 | | Descriptor: | SN243, ZINC ION | | Authors: | Neun, S, Brear, P, Campbell, E, Omari, K, Wagner, O, Hyvonen, M, Hollfelder, F. | | Deposit date: | 2021-12-01 | | Release date: | 2022-10-12 | | Last modified: | 2023-03-29 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Functional metagenomic screening identifies an unexpected beta-glucuronidase.
Nat.Chem.Biol., 18, 2022
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2MKJ
 | | Solution structure of tandem RRM domains of cytoplasmic polyadenylation element binding protein 4 (CPEB4) in free state | | Descriptor: | Cytoplasmic polyadenylation element-binding protein 4 | | Authors: | Afroz, T, Skrisovska, L, Belloc, E, Boixet, J.G, Mendez, R, Allain, F.H.-T. | | Deposit date: | 2014-02-07 | | Release date: | 2014-07-23 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | A fly trap mechanism provides sequence-specific RNA recognition by CPEB proteins
Genes Dev., 28, 2014
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2MKK
 | | Structural model of tandem RRM domains of cytoplasmic polyadenylation element binding protein 1 (CPEB1) in complex with RNA | | Descriptor: | Cytoplasmic polyadenylation element-binding protein 1, RNA (5'-R(*UP*UP*UP*UP*A)-3') | | Authors: | Afroz, T, Skrisovska, L, Belloc, E, Boixet, J.G, Mendez, R, Allain, F.H.-T. | | Deposit date: | 2014-02-07 | | Release date: | 2014-07-23 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | A fly trap mechanism provides sequence-specific RNA recognition by CPEB proteins
Genes Dev., 28, 2014
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2MKI
 | | Solution structure of tandem RRM domains of cytoplasmic polyadenylation element binding protein 4 (CPEB4) in complex with RNA | | Descriptor: | Cytoplasmic polyadenylation element-binding protein 4, RNA (5'-R(*CP*UP*UP*UP*A)-3') | | Authors: | Afroz, T, Skrisovska, L, Belloc, E, Boixet, J.G, Mendez, R, Allain, F.H.-T. | | Deposit date: | 2014-02-07 | | Release date: | 2014-07-23 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | A fly trap mechanism provides sequence-specific RNA recognition by CPEB proteins
Genes Dev., 28, 2014
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2MKH
 | | Solution structure of tandem RRM domains of cytoplasmic polyadenylation element binding protein 1 (CPEB1) in free state | | Descriptor: | Cytoplasmic polyadenylation element-binding protein 1 | | Authors: | Afroz, T, Skrisovska, L, Belloc, E, Boixet, J.G, Mendez, R, Allain, F.H.-T. | | Deposit date: | 2014-02-07 | | Release date: | 2014-07-23 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | A fly trap mechanism provides sequence-specific RNA recognition by CPEB proteins
Genes Dev., 28, 2014
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2MKE
 | | Solution structure of CPEB1 ZZ domain in the free state | | Descriptor: | Cytoplasmic polyadenylation element-binding protein 1, ZINC ION | | Authors: | Afroz, T, Skrisovska, L, Belloc, E, Boixet, J.G, Mendez, R, Allain, F.H.-T. | | Deposit date: | 2014-02-06 | | Release date: | 2014-07-23 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | A fly trap mechanism provides sequence-specific RNA recognition by CPEB proteins
Genes Dev., 28, 2014
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2CEK
 | | Conformational Flexibility in the Peripheral Site of Torpedo californica Acetylcholinesterase Revealed by the Complex Structure with a Bifunctional Inhibitor | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Sanson, B, Colletier, J.P, Nachon, F, Gabellieri, E, Fattorusso, C, Campiani, G, Weik, M. | | Deposit date: | 2006-02-08 | | Release date: | 2006-04-10 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Conformational flexibility in the peripheral site of Torpedo californica acetylcholinesterase revealed by the complex structure with a bifunctional inhibitor.
J. Am. Chem. Soc., 128, 2006
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6HQF
 | | Structure of Phenylalanine ammonia-lyase from Petroselinum crispum in complex with (R)-APEP | | Descriptor: | Phenylalanine ammonia-lyase 1, [(1R)-1-amino-2-phenylethyl]phosphonic acid | | Authors: | Bata, Z, Molnar, B, Leveles, I, Poppe, L, Vertessy, G.B. | | Deposit date: | 2018-09-24 | | Release date: | 2019-10-09 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.76 Å) | | Cite: | Substrate Tunnel Engineering Aided by X-ray Crystallography and Functional Dynamics Swaps the Function of MIO-Enzymes
Acs Catalysis, 2021
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6H2O
 | | APO structure of Phenylalanine ammonia-lyase from Petroselinum crispum | | Descriptor: | Phenylalanine ammonia-lyase 1 | | Authors: | Molnar, B, Bata, Z, Leveles, I, Poppe, L, Vertessy, G.B. | | Deposit date: | 2018-07-14 | | Release date: | 2019-07-31 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Substrate Tunnel Engineering Aided by X-ray Crystallography and Functional Dynamics Swaps the Function of MIO-Enzymes
Acs Catalysis, 2021
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6F6T
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6DHM
 | | Bovine glutamate dehydrogenase complexed with zinc | | Descriptor: | GLUTAMIC ACID, GUANOSINE-5'-TRIPHOSPHATE, Glutamate dehydrogenase 1, ... | | Authors: | Smith, T.J. | | Deposit date: | 2018-05-20 | | Release date: | 2018-07-25 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | A novel mechanism of V-type zinc inhibition of glutamate dehydrogenase results from disruption of subunit interactions necessary for efficient catalysis.
FEBS J., 278, 2011
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6DHN
 | | Bovine glutamate dehydrogenase complexed with Eu3+ | | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, GLUTAMIC ACID, GUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Smith, T.J. | | Deposit date: | 2018-05-20 | | Release date: | 2018-07-25 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | A novel mechanism of V-type zinc inhibition of glutamate dehydrogenase results from disruption of subunit interactions necessary for efficient catalysis.
FEBS J., 278, 2011
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7P2B
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6EGR
 | | Crystal structure of Citrobacter freundii methionine gamma-lyase with V358Y replacement | | Descriptor: | DI(HYDROXYETHYL)ETHER, Methionine gamma-lyase, PYRIDOXAL-5'-PHOSPHATE, ... | | Authors: | Revtovich, S.V, Demitri, N, Raboni, S, Nikulin, A.D, Morozova, E.A, Demidkina, T.V, Storici, P, Mozzarelli, A. | | Deposit date: | 2017-09-12 | | Release date: | 2018-10-10 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | Engineering methionine gamma-lyase from Citrobacter freundii for anticancer activity.
Biochim Biophys Acta Proteins Proteom, 1866, 2018
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6MNX
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4BFD
 | | CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH CHEMICAL LIGAND | | Descriptor: | BETA-SECRETASE 1, DIMETHYL SULFOXIDE, N-[3-[(1S,3S,6S)-5-azanyl-3-methyl-4-azabicyclo[4.1.0]hept-4-en-3-yl]-4-fluoranyl-phenyl]-5-chloranyl-pyridine-2-carbox amide, ... | | Authors: | Banner, D.W, Benz, J, Stihle, M. | | Deposit date: | 2013-03-18 | | Release date: | 2013-06-19 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Bace1 Inhibitors: A Head Group Scan on a Series of Amides.
Bioorg.Med.Chem.Lett., 23, 2013
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4BEK
 | | CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH CHEMICAL LIGAND | | Descriptor: | (4S)-4-(4-methoxyphenyl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine, BETA-SECRETASE 1, DIMETHYL SULFOXIDE, ... | | Authors: | Banner, D.W, Benz, J, Stihle, M. | | Deposit date: | 2013-03-11 | | Release date: | 2013-06-19 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.39 Å) | | Cite: | Bace1 Inhibitors: A Head Group Scan on a Series of Amides.
Bioorg.Med.Chem.Lett., 23, 2013
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4YBI
 | | Crystal structure of BACE with amino thiazine inhibitor LY2811376 | | Descriptor: | (4S)-4-[2,4-difluoro-5-(pyrimidin-5-yl)phenyl]-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine, Beta-secretase 1, GLYCEROL | | Authors: | Timm, D.E. | | Deposit date: | 2015-02-18 | | Release date: | 2015-04-01 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | Robust central reduction of amyloid-beta in humans with an orally available, non-peptidic beta-secretase inhibitor.
J.Neurosci., 31, 2011
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1G6W
 | | CRYSTAL STRUCTURE OF THE GLOBULAR REGION OF THE PRION PROTEIN URE2 FROM THE YEAST SACCAROMYCES CEREVISIAE | | Descriptor: | URE2 PROTEIN | | Authors: | Bousset, L, Belrhali, H, Janin, J, Melki, R, Morera, S. | | Deposit date: | 2000-11-08 | | Release date: | 2001-02-21 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure of the globular region of the prion protein Ure2 from the yeast Saccharomyces cerevisiae.
Structure, 9, 2001
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1G6Y
 | | CRYSTAL STRUCTURE OF THE GLOBULAR REGION OF THE PRION PROTEIN URE2 FROM YEAST SACCHAROMYCES CEREVISIAE | | Descriptor: | URE2 PROTEIN | | Authors: | Bousset, L, Belrhali, H, Janin, J, Melki, R, Morera, S. | | Deposit date: | 2000-11-08 | | Release date: | 2001-02-21 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structure of the globular region of the prion protein Ure2 from the yeast Saccharomyces cerevisiae.
Structure, 9, 2001
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3GTU
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