4BEK

CRYSTAL STRUCTURE OF BACE-1 IN COMPLEX WITH CHEMICAL LIGAND

Summary for 4BEK

Entry DOI	10.2210/pdb4bek/pdb
Related	4BEL
Descriptor	BETA-SECRETASE 1, (4S)-4-(4-methoxyphenyl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine, SODIUM ION, ... (5 entities in total)
Functional Keywords	hydrolase
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	45914.45
Authors	Banner, D.W.,Benz, J.,Stihle, M. (deposition date: 2013-03-11, release date: 2013-06-19, Last modification date: 2023-12-20)
Primary citation	Woltering, T.J.,Wostl, W.,Hilpert, H.,Rogers-Evans, M.,Pinard, E.,Mayweg, A.,Gobel, M.,Banner, D.W.,Benz, J.,Travagli, M.,Pollastrini, M.,Marconi, G.,Gabellieri, E.,Guba, W.,Mauser, H.,Andreini, M.,Jacobsen, H.,Power, E.,Narquizian, R. Bace1 Inhibitors: A Head Group Scan on a Series of Amides. Bioorg.Med.Chem.Lett., 23:4239-, 2013 Cited by PubMed: 23735744 DOI: 10.1016/J.BMCL.2013.05.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.39 Å)

Structure validation