2ABW
 
 | | Glutaminase subunit of the plasmodial PLP synthase (Vitamin B6 biosynthesis) | | Descriptor: | Pdx2 protein, TETRAETHYLENE GLYCOL | | Authors: | Gengenbacher, M, Fitzpatrick, T.B, Raschle, T, Flicker, K, Sinning, I, Mueller, S, Macheroux, P, Tews, I, Kappes, B. | | Deposit date: | 2005-07-17 | | Release date: | 2006-01-10 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.62 Å) | | Cite: | Vitamin B6 Biosynthesis by the Malaria Parasite Plasmodium falciparum: Biochemical and structural insights
J.Biol.Chem., 281, 2006
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7Z3N
 | | Cryo-EM structure of the ribosome-associated RAC complex on the 80S ribosome - RAC-1 conformation | | Descriptor: | 18S rRNA, 26S rRNA, 40S ribosomal protein S0, ... | | Authors: | Kisonaite, M, Wild, K, Sinning, I. | | Deposit date: | 2022-03-02 | | Release date: | 2023-04-12 | | Last modified: | 2023-05-31 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural inventory of cotranslational protein folding by the eukaryotic RAC complex.
Nat.Struct.Mol.Biol., 30, 2023
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7Z3O
 | | Cryo-EM structure of the ribosome-associated RAC complex on the 80S ribosome - RAC-2 conformation | | Descriptor: | 18S rRNA, 26S rRNA, 40S ribosomal protein S0, ... | | Authors: | Kisonaite, M, Wild, K, Sinning, I. | | Deposit date: | 2022-03-02 | | Release date: | 2023-04-12 | | Last modified: | 2023-05-31 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural inventory of cotranslational protein folding by the eukaryotic RAC complex.
Nat.Struct.Mol.Biol., 30, 2023
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7OJU
 | | Chaetomium thermophilum Naa50 GNAT-domain in complex with bisubstrate analogue CoA-Ac-MVNAL | | Descriptor: | CARBOXYMETHYL COENZYME *A, GLYCEROL, HEXAETHYLENE GLYCOL, ... | | Authors: | Weidenhausen, J, Kopp, J, Sinning, I. | | Deposit date: | 2021-05-17 | | Release date: | 2022-09-28 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.1 Å) | | Cite: | Extended N-Terminal Acetyltransferase Naa50 in Filamentous Fungi Adds to Naa50 Diversity.
Int J Mol Sci, 23, 2022
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3UI2
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6YGU
 | | Crystal structure of the minimal Mtr4-Red1 complex (single chain) from Chaetomium thermophilum | | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, ATP dependent RNA helicase (Dob1)-like protein, ... | | Authors: | Dobrev, N, Ahmed, Y.L, Sinning, I. | | Deposit date: | 2020-03-27 | | Release date: | 2021-05-05 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | The zinc-finger protein Red1 orchestrates MTREC submodules and binds the Mtl1 helicase arch domain.
Nat Commun, 12, 2021
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6YFV
 | | Crystal structure of Mtr4-Red1 minimal complex from Chaetomium thermophilum | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ATP dependent RNA helicase (Dob1)-like protein, Red1, ... | | Authors: | Dobrev, N, Ahmed, Y.L, Sinning, I. | | Deposit date: | 2020-03-26 | | Release date: | 2021-05-05 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | The zinc-finger protein Red1 orchestrates MTREC submodules and binds the Mtl1 helicase arch domain.
Nat Commun, 12, 2021
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6Z00
 | | Arabidopsis thaliana Naa50 in complex with bisubstrate analogue CoA-Ac-MVNAL | | Descriptor: | Acyl-CoA N-acyltransferases (NAT) superfamily protein, CARBOXYMETHYL COENZYME *A, MET-VAL-ASN-ALA-LEU | | Authors: | Weidenhausen, J, Kopp, J, Lapouge, K, Sinning, I. | | Deposit date: | 2020-05-07 | | Release date: | 2020-12-30 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.42 Å) | | Cite: | Structural and functional characterization of the N-terminal acetyltransferase Naa50.
Structure, 29, 2021
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6YZZ
 | | Arabidopsis thaliana Naa50 in complex with AcCoA | | Descriptor: | ACETYL COENZYME *A, N-alpha-acetyltransferase 50 | | Authors: | Weidenhausen, J, Kopp, J, Lapouge, K, Sinning, I. | | Deposit date: | 2020-05-07 | | Release date: | 2020-12-30 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.79 Å) | | Cite: | Structural and functional characterization of the N-terminal acetyltransferase Naa50.
Structure, 29, 2021
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7Q72
 | | Structure of Pla1 in complex with Red1 | | Descriptor: | NURS complex subunit red1, Poly(A) polymerase pla1 | | Authors: | Soni, K, Wild, K, Sinning, I. | | Deposit date: | 2021-11-09 | | Release date: | 2022-12-07 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Mechanistic insights into RNA surveillance by the canonical poly(A) polymerase Pla1 of the MTREC complex.
Nat Commun, 14, 2023
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8ODU
 | | Chaetomium thermophilum Get1/Get2 heterotetramer in complex with a Get3 dimer (amphipol) | | Descriptor: | ATPase GET3, Protein GET2,Protein GET1, ZINC ION | | Authors: | McDowell, M.A, Wild, K, Sinning, I. | | Deposit date: | 2023-03-09 | | Release date: | 2023-11-29 | | Method: | ELECTRON MICROSCOPY (5 Å) | | Cite: | The GET insertase exhibits conformational plasticity and induces membrane thinning.
Nat Commun, 14, 2023
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8ODV
 | | Chaetomium thermophilum Get1/Get2 heterotetramer in complex with a Get3 dimer (nanodisc) | | Descriptor: | ATPase GET3, Protein GET2,Protein GET1, ZINC ION | | Authors: | McDowell, M.A, Wild, K, Sinning, I. | | Deposit date: | 2023-03-09 | | Release date: | 2023-11-29 | | Method: | ELECTRON MICROSCOPY (4.7 Å) | | Cite: | The GET insertase exhibits conformational plasticity and induces membrane thinning.
Nat Commun, 14, 2023
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3IQX
 | | ADP complex of C.therm. Get3 in closed form | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Tail-anchored protein targeting factor Get3, ... | | Authors: | Bozkurt, G, Wild, K, Sinning, I. | | Deposit date: | 2009-08-21 | | Release date: | 2009-12-15 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Structural insights into tail-anchored protein binding and membrane insertion by Get3.
Proc.Natl.Acad.Sci.USA, 106, 2009
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3IQW
 | | AMPPNP complex of C. therm. Get3 | | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Tail-anchored protein targeting factor Get3, ... | | Authors: | Bozkurt, G, Wild, K, Sinning, I. | | Deposit date: | 2009-08-21 | | Release date: | 2009-12-15 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structural insights into tail-anchored protein binding and membrane insertion by Get3.
Proc.Natl.Acad.Sci.USA, 106, 2009
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1SMB
 | | Crystal Structure of Golgi-Associated PR-1 protein | | Descriptor: | 17kD fetal brain protein | | Authors: | Serrano, R.L, Kuhn, A, Hendricks, A, Helms, J.B, Sinning, I, Groves, M.R. | | Deposit date: | 2004-03-08 | | Release date: | 2004-09-14 | | Last modified: | 2025-03-26 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Structural analysis of the human Golgi-associated plant pathogenesis related protein GAPR-1 implicates dimerization as a regulatory mechanism
J.Mol.Biol., 339, 2004
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6Y31
 | | NG domain of human SRP54 T117 deletion mutant | | Descriptor: | Signal recognition particle 54 kDa protein | | Authors: | Juaire, K.D, Lapouge, K, Becker, M.M.M, Kotova, I, Haas, M, Carapito, R, Wild, K, Bahram, S, Sinning, I. | | Deposit date: | 2020-02-17 | | Release date: | 2020-09-23 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (4.001 Å) | | Cite: | Structural and Functional Impact of SRP54 Mutations Causing Severe Congenital Neutropenia.
Structure, 29, 2021
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6Y32
 | | Structure of the GTPase heterodimer of human SRP54 and SRalpha | | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, SULFATE ION, ... | | Authors: | Juaire, K.D, Becker, M.M.M, Wild, K, Sinning, I. | | Deposit date: | 2020-02-17 | | Release date: | 2020-09-23 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural and Functional Impact of SRP54 Mutations Causing Severe Congenital Neutropenia.
Structure, 29, 2021
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6Y2Z
 | | NG domain of human SRP54 | | Descriptor: | MAGNESIUM ION, PHOSPHATE ION, Signal recognition particle 54 kDa protein | | Authors: | Juaire, K.D, Wild, K, Sinning, I. | | Deposit date: | 2020-02-17 | | Release date: | 2020-09-23 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Structural and Functional Impact of SRP54 Mutations Causing Severe Congenital Neutropenia.
Structure, 29, 2021
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6Y30
 | | NG domain of human SRP54 T115A mutant | | Descriptor: | Signal recognition particle 54 kDa protein | | Authors: | Juaire, K.D, Wild, K, Sinning, I. | | Deposit date: | 2020-02-17 | | Release date: | 2020-09-23 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Structural and Functional Impact of SRP54 Mutations Causing Severe Congenital Neutropenia.
Structure, 29, 2021
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4WJU
 | | Crystal structure of Rsa4 from Saccharomyces cerevisiae | | Descriptor: | GLYCEROL, Ribosome assembly protein 4 | | Authors: | Holdermann, I, Bassler, J, Hurt, E, Sinning, I. | | Deposit date: | 2014-10-01 | | Release date: | 2014-11-19 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation.
J.Cell Biol., 207, 2014
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4WJV
 | | Crystal structure of Rsa4 in complex with the Nsa2 binding peptide | | Descriptor: | Maltose-binding periplasmic protein, Ribosome assembly protein 4, Ribosome biogenesis protein NSA2, ... | | Authors: | Holdermann, I, Paternoga, H, Bassler, J, Hurt, E, Sinning, I. | | Deposit date: | 2014-10-01 | | Release date: | 2014-11-19 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | A network of assembly factors is involved in remodeling rRNA elements during preribosome maturation.
J.Cell Biol., 207, 2014
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4WJS
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3SJB
 | | Crystal structure of S. cerevisiae Get3 in the open state in complex with Get1 cytosolic domain | | Descriptor: | ATPase GET3, Golgi to ER traffic protein 1, PHOSPHATE ION, ... | | Authors: | Reitz, S, Wild, K, Sinning, I. | | Deposit date: | 2011-06-21 | | Release date: | 2011-07-06 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Structural basis for tail-anchored membrane protein biogenesis by the Get3-receptor complex.
Science, 333, 2011
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3SYN
 | | Crystal structure of FlhF in complex with its activator | | Descriptor: | ALUMINUM FLUORIDE, ATP-binding protein YlxH, Flagellar biosynthesis protein flhF, ... | | Authors: | Bange, G, Kuemmerer, N, Wild, K, Sinning, I. | | Deposit date: | 2011-07-18 | | Release date: | 2011-11-09 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (3.063 Å) | | Cite: | Structural basis for the molecular evolution of SRP-GTPase activation by protein.
Nat.Struct.Mol.Biol., 18, 2011
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8ONX
 | | High resolution structure of Chaetomium thermophilum MAP2 | | Descriptor: | MANGANESE (II) ION, Methionine aminopeptidase 2 | | Authors: | Klein, M.A, Wild, K, Kisonaite, M, Sinning, I. | | Deposit date: | 2023-04-04 | | Release date: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Methionine aminopeptidase 2 and its autoproteolysis product have different binding sites on the ribosome.
Nat Commun, 15, 2024
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