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3N75
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BU of 3n75 by Molmil
X-ray Crystal Structure of the Escherichia coli Inducible Lysine Decarboxylase LdcI
Descriptor: GLYCEROL, GUANOSINE-5',3'-TETRAPHOSPHATE, HEXAETHYLENE GLYCOL, ...
Authors:Kanjee, U, Alexopoulos, E, Pai, E.F, Houry, W.A.
Deposit date:2010-05-26
Release date:2011-02-16
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Linkage between the bacterial acid stress and stringent responses: the structure of the inducible lysine decarboxylase.
Embo J., 30, 2011
1OZ1
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BU of 1oz1 by Molmil
P38 MITOGEN-ACTIVATED KINASE IN COMPLEX WITH 4-AZAINDOLE INHIBITOR
Descriptor: 3-(4-FLUOROPHENYL)-2-PYRIDIN-4-YL-1H-PYRROLO[3,2-B]PYRIDIN-1-OL, Mitogen-activated protein kinase 14
Authors:Lovejoy, B, Villasenor, A, Browner, M, Dunten, P.
Deposit date:2003-04-07
Release date:2003-09-23
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Design and synthesis of 4-azaindoles as inhibitors of p38 MAP kinase.
J.Med.Chem., 46, 2003
8FGX
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BU of 8fgx by Molmil
Cryo-EM structure of the STAR-0215 Fab in complex with active human plasma kallikrein
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Plasma kallikrein light chain, STAR-0215 Heavy chain, ...
Authors:Fuller, J.R, Biris, N, Bista, P.
Deposit date:2022-12-13
Release date:2023-09-06
Last modified:2023-10-25
Method:ELECTRON MICROSCOPY (2.62 Å)
Cite:STAR-0215 is a Novel, Long-Acting Monoclonal Antibody Inhibitor of Plasma Kallikrein for the Potential Treatment of Hereditary Angioedema.
J.Pharmacol.Exp.Ther., 387, 2023
5L0E
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BU of 5l0e by Molmil
Crystal Structure of Autotaxin and Compound 1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-(3-{2-[(2,3-dihydro-1H-inden-2-yl)amino]-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl}propanoyl)-1,3-benzoxazol-2(3H)-one, CHLORIDE ION, ...
Authors:Durbin, J.D.
Deposit date:2016-07-27
Release date:2016-08-10
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.06 Å)
Cite:Novel Autotaxin Inhibitors for the Treatment of Osteoarthritis Pain: Lead Optimization via Structure-Based Drug Design.
Acs Med.Chem.Lett., 7, 2016
3Q16
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BU of 3q16 by Molmil
Linkage between the Bacterial Acid Stress and Stringent Responses: The Structure of the Inducible Lysine Decarboxylase
Descriptor: Lysine decarboxylase, inducible
Authors:El Bakkouri, M, Pai, E.F, Houry, W.A.
Deposit date:2010-12-16
Release date:2011-02-16
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (4.1 Å)
Cite:Linkage between the bacterial acid stress and stringent responses: the structure of the inducible lysine decarboxylase.
Embo J., 30, 2011
4JOA
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BU of 4joa by Molmil
Crystal Structure of Human Anaplastic Lymphoma Kinase in complex with 7-azaindole based inhibitor
Descriptor: 3-[1-(2,5-difluorobenzyl)-1H-pyrazol-4-yl]-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine, ALK tyrosine kinase receptor
Authors:Hosahalli, S, Krishnamurthy, N.R, Lakshminarasimhan, A.
Deposit date:2013-03-18
Release date:2013-07-17
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Discovery of 7-azaindole based anaplastic lymphoma kinase (ALK) inhibitors: wild type and mutant (L1196M) active compounds with unique binding mode
Bioorg.Med.Chem.Lett., 23, 2013
5L0K
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BU of 5l0k by Molmil
Crystal Structure of Autotaxin and Compound PF-8380
Descriptor: (3,5-dichlorophenyl)methyl 4-[3-oxo-3-(2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)propyl]piperazine-1-carboxylate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Durbin, J.D.
Deposit date:2016-07-27
Release date:2016-08-10
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:Novel Autotaxin Inhibitors for the Treatment of Osteoarthritis Pain: Lead Optimization via Structure-Based Drug Design.
Acs Med.Chem.Lett., 7, 2016
5L0B
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BU of 5l0b by Molmil
Crystal Structure of Autotaxin and Compound 1
Descriptor: 1-{2-[(2,3-dihydro-1H-inden-2-yl)amino]-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl}ethan-1-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
Authors:Durbin, J.D.
Deposit date:2016-07-27
Release date:2016-08-10
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Novel Autotaxin Inhibitors for the Treatment of Osteoarthritis Pain: Lead Optimization via Structure-Based Drug Design.
Acs Med.Chem.Lett., 7, 2016
5T1O
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BU of 5t1o by Molmil
Solution-state NMR and SAXS structural ensemble of NPr (1-85) in complex with EIN-Ntr (170-424)
Descriptor: Phosphocarrier protein NPr, Phosphoenolpyruvate-protein phosphotransferase PtsP
Authors:Strickland, M, Stanley, A.M, Wang, G, Schwieters, C.D, Buchanan, S, Peterkofsky, A, Tjandra, N.
Deposit date:2016-08-19
Release date:2016-11-16
Last modified:2024-05-15
Method:SOLUTION NMR, SOLUTION SCATTERING
Cite:Structure of the NPr:EIN(Ntr) Complex: Mechanism for Specificity in Paralogous Phosphotransferase Systems.
Structure, 24, 2016
4Q13
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BU of 4q13 by Molmil
Apo Estrogen Receptor Alpha Ligand Binding Domain D538G Mutant with a glucocorticoid receptor-interacting protein 1 NR box II peptide
Descriptor: Estrogen receptor, Glucocorticoid receptor-interacting protein 1 NR box II peptide
Authors:Fanning, S.W, Panchamukhi, S, Greene, G.L.
Deposit date:2014-04-02
Release date:2015-04-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation.
Elife, 5, 2016
4PXM
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BU of 4pxm by Molmil
The Estrogen Receptor Alpha Ligand Binding Domain D538G Mutant in Complex with Estradiol and a glucocorticoid receptor-interacting protein 1 NR box II peptide
Descriptor: ESTRADIOL, Estrogen receptor, Nuclear receptor coactivator 2
Authors:Fanning, S.W, Panchamukhi, S, Greene, G.L.
Deposit date:2014-03-24
Release date:2015-04-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation.
Elife, 5, 2016
7DXJ
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BU of 7dxj by Molmil
Human 46QHuntingtin-HAP40 complex structure
Descriptor: 40-kDa huntingtin-associated protein, Huntingtin
Authors:Guo, Q, Fernandez-Busnadiego, R.
Deposit date:2021-01-19
Release date:2021-03-24
Last modified:2021-10-06
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Pathological polyQ expansion does not alter the conformation of the Huntingtin-HAP40 complex.
Structure, 29, 2021
7DXK
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BU of 7dxk by Molmil
Human 128QHuntingtin-HAP40 complex structure
Descriptor: 40-kDa huntingtin-associated protein, Huntingtin
Authors:Guo, Q, Fernandez-Busnadiego, R.
Deposit date:2021-01-19
Release date:2021-03-24
Last modified:2021-10-06
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Pathological polyQ expansion does not alter the conformation of the Huntingtin-HAP40 complex.
Structure, 29, 2021
4Q50
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BU of 4q50 by Molmil
The Estrogen Receptor Alpha Ligand Binding Domain D538G Mutant in Complex with 4-hydroxytamoxifen
Descriptor: 4-HYDROXYTAMOXIFEN, Estrogen receptor, SULFATE ION
Authors:Fanning, S.W, Greene, G.L.
Deposit date:2014-04-15
Release date:2015-04-15
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.07 Å)
Cite:Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation.
Elife, 5, 2016
2NPW
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BU of 2npw by Molmil
Solution Structures of a DNA Dodecamer Duplex with a Cisplatin 1,2-d(GG) Intrastrand Cross-Link
Descriptor: 5'-D(*CP*CP*TP*CP*AP*GP*GP*CP*CP*TP*CP*C)-3', 5'-D(*GP*GP*AP*GP*GP*CP*CP*TP*GP*AP*GP*G)-3', Cisplatin
Authors:Wu, Y, Bhattacharyya, D, Chaney, S, Campbell, S.
Deposit date:2006-10-30
Release date:2007-06-12
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Solution Structures of a DNA Dodecamer Duplex with and without a Cisplatin 1,2-d(GG) Intrastrand Cross-Link: Comparison with the Same DNA Duplex Containing an Oxaliplatin 1,2-d(GG) Intrastrand Cross-Link
Biochemistry, 46, 2007
2NQ1
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BU of 2nq1 by Molmil
Solution Structures of a DNA Dodecamer Duplex
Descriptor: 5'-D(*CP*CP*TP*CP*AP*GP*GP*CP*CP*TP*CP*C)-3', 5'-D(*GP*GP*AP*GP*GP*CP*CP*TP*GP*AP*GP*G)-3'
Authors:Bhattacharyya, D, Wu, Y, Chaney, S, Campbell, S.
Deposit date:2006-10-30
Release date:2007-06-12
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Solution Structures of a DNA Dodecamer Duplex with and without a Cisplatin 1,2-d(GG) Intrastrand Cross-Link: Comparison with the Same DNA Duplex Containing an Oxaliplatin 1,2-d(GG) Intrastrand Cross-Link
Biochemistry, 46, 2007
2NQ0
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BU of 2nq0 by Molmil
Solution Structures of a DNA Dodecamer Duplex with a Cisplatin 1,2-d(GG) Intrastrand Cross-Link
Descriptor: 5'-D(*CP*CP*TP*CP*AP*GP*GP*CP*CP*TP*CP*C)-3', 5'-D(*GP*GP*AP*GP*GP*CP*CP*TP*GP*AP*GP*G)-3', Cisplatin
Authors:Wu, Y, Bhattacharyya, D, Chaney, S, Campbell, S.
Deposit date:2006-10-30
Release date:2007-06-12
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Solution Structures of a DNA Dodecamer Duplex with and without a Cisplatin 1,2-d(GG) Intrastrand Cross-Link: Comparison with the Same DNA Duplex Containing an Oxaliplatin 1,2-d(GG) Intrastrand Cross-Link
Biochemistry, 46, 2007
2NQ4
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BU of 2nq4 by Molmil
Solution Structures of a DNA Dodecamer Duplex
Descriptor: 5'-D(*CP*CP*TP*CP*AP*GP*GP*CP*CP*TP*CP*C)-3', 5'-D(*GP*GP*AP*GP*GP*CP*CP*TP*GP*AP*GP*G)-3'
Authors:Bhattacharyya, D, Wu, Y, Chaney, S, Campbell, S.
Deposit date:2006-10-30
Release date:2007-06-12
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Solution Structures of a DNA Dodecamer Duplex with and without a Cisplatin 1,2-d(GG) Intrastrand Cross-Link: Comparison with the Same DNA Duplex Containing an Oxaliplatin 1,2-d(GG) Intrastrand Cross-Link
Biochemistry, 46, 2007
6FRK
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BU of 6frk by Molmil
Structure of a prehandover mammalian ribosomal SRP and SRP receptor targeting complex
Descriptor: 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ...
Authors:Kobayashi, K, Jomaa, A, Ban, N.
Deposit date:2018-02-16
Release date:2018-03-28
Last modified:2018-05-02
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structure of a prehandover mammalian ribosomal SRP·SRP receptor targeting complex.
Science, 360, 2018
2MD6
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BU of 2md6 by Molmil
NMR SOLUTION STRUCTURE OF ALPHA CONOTOXIN LO1A FROM Conus longurionis
Descriptor: ALPHA CONOTOXIN LO1A
Authors:Maiti, M, Lescrinier, E, Herdewijn, P, Lebbe, E.K.M, Peigneur, S, D'Souza, L, Tytgat, J.
Deposit date:2013-09-01
Release date:2014-03-05
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structure-Function Elucidation of a New alpha-Conotoxin, Lo1a, from Conus longurionis.
J.Biol.Chem., 289, 2014
3NUL
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BU of 3nul by Molmil
Profilin I from Arabidopsis thaliana
Descriptor: GLYCEROL, PROFILIN I, SULFATE ION
Authors:Thorn, K, Christensen, H.E.M, Shigeta, R, Huddler, D, Chua, N.-H, Shalaby, L, Lindberg, U, Schutt, C.E.
Deposit date:1996-11-27
Release date:1997-12-03
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The crystal structure of a major allergen from plants.
Structure, 5, 1997
4LR6
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BU of 4lr6 by Molmil
Structure of BRD4 bromodomain 1 with a 3-methyl-4-phenylisoxazol-5-amine fragment
Descriptor: 3-methyl-4-phenyl-1,2-oxazol-5-amine, Bromodomain-containing protein 4, FORMIC ACID
Authors:Jayaram, H, Poy, F, Gehling, V, Hewitt, M, Vaswani, R, Leblanc, Y, Cote, A, Nasveschuk, C, Taylor, A, Harmange, J.-C, Audia, J, Pardo, E, Joshi, S, Sandy, P, Mertz, J, Sims, R, Bergeron, L, Bryant, B, Ravichandran, S, Yellapuntala, S, Nandana, B.S, Birudukota, S, Albrecht, B, Bellon, S.
Deposit date:2013-07-19
Release date:2013-08-07
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:Discovery, Design, and Optimization of Isoxazole Azepine BET Inhibitors.
ACS Med Chem Lett, 4, 2013
1WMA
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BU of 1wma by Molmil
Crystal structure of human CBR1 in complex with Hydroxy-PP
Descriptor: 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, 3-(4-AMINO-1-TERT-BUTYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL)PHENOL, ...
Authors:Rauh, D, Bateman, R, Shokat, K.M.
Deposit date:2004-07-06
Release date:2005-04-26
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.24 Å)
Cite:An unbiased cell morphology-based screen for new, biologically active small molecules
Plos Biol., 3, 2005
4M7C
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BU of 4m7c by Molmil
Crystal structure of the TRF2-binding motif of SLX4 in complex with the TRFH domain of TRF2
Descriptor: Peptide from Structure-specific endonuclease subunit SLX4, Telomeric repeat-binding factor 2
Authors:Wan, B, Chen, Y, Wu, J, Liu, Y, Lei, M.
Deposit date:2013-08-12
Release date:2013-09-25
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:SLX4 Assembles a Telomere Maintenance Toolkit by Bridging Multiple Endonucleases with Telomeres
Cell Rep, 4, 2013
2L3N
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BU of 2l3n by Molmil
Solution structure of Rap1-Taz1 fusion protein
Descriptor: DNA-binding protein rap1,Telomere length regulator taz1
Authors:Zhou, Z.R, Wang, F, Chen, Y, Lei, M, Hu, H.
Deposit date:2010-09-19
Release date:2011-01-12
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms.
Nat.Struct.Mol.Biol., 18, 2011

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