3BXF
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![BU of 3bxf by Molmil](/molmil-images/mine/3bxf) | Crystal structure of effector binding domain of central glycolytic gene regulator (CggR) from Bacillus subtilis in complex with effector fructose-1,6-bisphosphate | Descriptor: | 1,3-DIHYDROXYACETONEPHOSPHATE, 1,6-di-O-phosphono-beta-D-fructofuranose, CHLORIDE ION, ... | Authors: | Rezacova, P, Otwinowski, Z. | Deposit date: | 2008-01-13 | Release date: | 2008-07-01 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structures of the effector-binding domain of repressor Central glycolytic gene Regulator from Bacillus subtilis reveal ligand-induced structural changes upon binding of several glycolytic intermediates. Mol.Microbiol., 69, 2008
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6W75
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![BU of 6w75 by Molmil](/molmil-images/mine/6w75) | 1.95 Angstrom Resolution Crystal Structure of NSP10 - NSP16 Complex from SARS-CoV-2 | Descriptor: | 2'-O-methyltransferase, FORMIC ACID, Non-structural protein 10, ... | Authors: | Minasov, G, Shuvalova, L, Rosas-Lemus, M, Kiryukhina, O, Wiersum, G, Godzik, A, Jaroszewski, L, Stogios, P.J, Skarina, T, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2020-03-18 | Release date: | 2020-03-25 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.951 Å) | Cite: | High-resolution structures of the SARS-CoV-2 2'- O -methyltransferase reveal strategies for structure-based inhibitor design. Sci.Signal., 13, 2020
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5DGG
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![BU of 5dgg by Molmil](/molmil-images/mine/5dgg) | Central domain of uncharacterized Lpg1148 protein from Legionella pneumophila | Descriptor: | CHLORIDE ION, Uncharacterized protein | Authors: | Osipiuk, J, Evdokimova, E, Yim, V, Joachimiak, A, Ensminger, A, Savchenko, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2015-08-27 | Release date: | 2015-09-16 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Diverse mechanisms of metaeffector activity in an intracellular bacterial pathogen, Legionella pneumophila. Mol. Syst. Biol., 12, 2016
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5CYV
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![BU of 5cyv by Molmil](/molmil-images/mine/5cyv) | Crystal structure of CouR from Rhodococcus jostii RHA1 bound to p-coumaroyl-CoA | Descriptor: | ACETATE ION, CHLORIDE ION, MAGNESIUM ION, ... | Authors: | Stogios, P.J, Xu, X, Dong, A, Savchenko, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2015-07-30 | Release date: | 2015-08-12 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | The activity of CouR, a MarR family transcriptional regulator, is modulated through a novel molecular mechanism. Nucleic Acids Res., 44, 2016
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2AV9
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![BU of 2av9 by Molmil](/molmil-images/mine/2av9) | Crystal Structure of the PA5185 protein from Pseudomonas Aeruginosa Strain PAO1. | Descriptor: | SULFATE ION, Thioesterase | Authors: | Chruszcz, M, Wang, S, Cymborowski, M, Kudritska, M, Evdokimova, E, Edwards, A, Savchenko, A, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2005-08-29 | Release date: | 2005-10-18 | Last modified: | 2022-04-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Function-biased choice of additives for optimization of protein crystallization - the case of the putative thioesterase PA5185 from Pseudomonas aeruginosa PAO1. Cryst.Growth Des., 8, 2008
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3HFU
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![BU of 3hfu by Molmil](/molmil-images/mine/3hfu) | Crystal structure of the ligand binding domain of E. coli CynR with its specific effector azide | Descriptor: | 1,2-ETHANEDIOL, AZIDE ION, HTH-type transcriptional regulator cynR | Authors: | Singer, A.U, Evdokimova, E, Kagan, O, Dong, A, Edwards, A.M, Savchenko, A. | Deposit date: | 2009-05-12 | Release date: | 2009-06-09 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of the ligand binding domain of E. coli CynR with its specific effector azide TO BE PUBLISHED
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2ESH
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![BU of 2esh by Molmil](/molmil-images/mine/2esh) | Crystal Structure of Conserved Protein of Unknown Function TM0937- a Potential Transcriptional Factor | Descriptor: | CALCIUM ION, conserved hypothetical protein TM0937 | Authors: | Liu, Y, Bochkareva, E, Zheng, H, Xu, X, Nocek, B, Lunin, V, Edward, A, Pai, E.F, Joachimiak, A, Savchenko, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2005-10-26 | Release date: | 2005-12-06 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal Structure of Conserved Hypothetical Protein TM0937 To be Published
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3CNV
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![BU of 3cnv by Molmil](/molmil-images/mine/3cnv) | Crystal structure of the ligand-binding domain of a putative GntR-family transcriptional regulator from Bordetella bronchiseptica | Descriptor: | CHLORIDE ION, CITRATE ANION, Putative GntR-family transcriptional regulator | Authors: | Zimmerman, M.D, Xu, X, Cui, H, Filippova, E.V, Savchenko, A, Edwards, A.M, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2008-03-26 | Release date: | 2008-04-29 | Last modified: | 2022-04-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of the ligand-binding domain of a putative GntR-family transcriptional regulator from Bordetella bronchiseptica. To be Published
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2LF3
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![BU of 2lf3 by Molmil](/molmil-images/mine/2lf3) | Solution NMR structure of HopPmaL_281_385 from Pseudomonas syringae pv. maculicola str. ES4326, Midwest Center for Structural Genomics target APC40104.5 and Northeast Structural Genomics Consortium target PsT2A | Descriptor: | Effector protein hopAB3 | Authors: | Wu, B, Yee, A, Houliston, S, Semesi, A, Garcia, M, Singer, A.U, Savchenko, A, Montelione, G.T, Joachimiak, A, Arrowsmith, C.H, Northeast Structural Genomics Consortium (NESG), Midwest Center for Structural Genomics (MCSG), Ontario Centre for Structural Proteomics (OCSP) | Deposit date: | 2011-06-28 | Release date: | 2011-07-13 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural Analysis of HopPmaL Reveals the Presence of a Second Adaptor Domain Common to the HopAB Family of Pseudomonas syringae Type III Effectors. Biochemistry, 51, 2012
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7TI9
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![BU of 7ti9 by Molmil](/molmil-images/mine/7ti9) | Crystal structure of the ubiquitin-like domain 1 (Ubl1) of Nsp3 from SARS-CoV-2, form 2 | Descriptor: | CHLORIDE ION, GLYCEROL, Papain-like protease nsp3 | Authors: | Stogios, P.J, Skarina, T, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2022-01-13 | Release date: | 2022-01-26 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.73 Å) | Cite: | Crystal structure of the ubiquitin-like domain 1 (Ubl1) of Nsp3 from SARS-CoV-2, form 2 To Be Published
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5UJY
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2LF6
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![BU of 2lf6 by Molmil](/molmil-images/mine/2lf6) | Solution NMR structure of HopABPph1448_220_320 from Pseudomonas syringae pv. phaseolicola str. 1448A, Midwest Center for Structural Genomics target APC40132.4 and Northeast Structural Genomics Consortium target PsT3A | Descriptor: | Effector protein hopAB1 | Authors: | Wu, B, Yee, A, Houliston, S, Semesi, A, Garcia, M, Singer, A.U, Savchenko, A, Montelione, G.T, Joachimiak, A, Arrowsmith, C.H, Northeast Structural Genomics Consortium (NESG), Midwest Center for Structural Genomics (MCSG), Ontario Centre for Structural Proteomics (OCSP) | Deposit date: | 2011-06-28 | Release date: | 2011-07-13 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural Analysis of HopPmaL Reveals the Presence of a Second Adaptor Domain Common to the HopAB Family of Pseudomonas syringae Type III Effectors. Biochemistry, 51, 2012
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5UJ1
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6U69
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![BU of 6u69 by Molmil](/molmil-images/mine/6u69) | Crystal structure of Yck2 from Candida albicans, apoenzyme | Descriptor: | CHLORIDE ION, GLYCEROL, SULFATE ION, ... | Authors: | Stogios, P.J, Evdokimova, E, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2019-08-29 | Release date: | 2019-10-09 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Overcoming Fungal Echinocandin Resistance through Inhibition of the Non-essential Stress Kinase Yck2. Cell Chem Biol, 27, 2020
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6U6A
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![BU of 6u6a by Molmil](/molmil-images/mine/6u6a) | Crystal structure of Yck2 from Candida albicans in complex with kinase inhibitor GW461484A | Descriptor: | 2-(4-fluorophenyl)-6-methyl-3-(pyridin-4-yl)pyrazolo[1,5-a]pyridine, SULFATE ION, Serine/threonine protein kinase | Authors: | Stogios, P.J, Evdokimova, E, Di Leo, R, Chang, C, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2019-08-29 | Release date: | 2019-10-30 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Overcoming Fungal Echinocandin Resistance through Inhibition of the Non-essential Stress Kinase Yck2. Cell Chem Biol, 27, 2020
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6D00
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![BU of 6d00 by Molmil](/molmil-images/mine/6d00) | Calcarisporiella thermophila Hsp104 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Calcarisporiella thermophila Hsp104 | Authors: | Zhang, K, Pintilie, G. | Deposit date: | 2018-04-09 | Release date: | 2019-04-03 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structure of Calcarisporiella thermophila Hsp104 Disaggregase that Antagonizes Diverse Proteotoxic Misfolding Events. Structure, 27, 2019
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3VDH
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![BU of 3vdh by Molmil](/molmil-images/mine/3vdh) | Crystal structure of PbGH5A, a glycoside hydrolase family 5 enzyme from Prevotella bryantii B14 | Descriptor: | B-1,4-endoglucanase, CHLORIDE ION | Authors: | Stogios, P.J, Evdokimova, E, Egorova, O, Yim, V, Joachimiak, A, Edwards, A.M, Savchenko, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2012-01-05 | Release date: | 2012-01-18 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | Structure-Function Analysis of a Mixed-linkage beta-Glucanase/Xyloglucanase from the Key Ruminal Bacteroidetes Prevotella bryantii B14. J.Biol.Chem., 291, 2016
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7UUJ
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![BU of 7uuj by Molmil](/molmil-images/mine/7uuj) | Crystal structure of aminoglycoside resistance enzyme ApmA, complex with gentamicin | Descriptor: | (2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4,6-DIAMINO-3-((2R,3R,6S)-3-AMINO-6-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-2-HYDR OXYCYCLOHEXYLOXY)-5-METHYL-4-(METHYLAMINO)-TETRAHYDRO-2H-PYRAN-3,5-DIOL, 1,2-ETHANEDIOL, Aminocyclitol acetyltransferase ApmA, ... | Authors: | Stogios, P.J, Evdokimova, E, Osipiuk, J, Di Leo, R, Bordeleau, E, Wright, G.D, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID) | Deposit date: | 2022-04-28 | Release date: | 2023-04-19 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Crystal structure of aminoglycoside resistance enzyme ApmA, complex with gentamicin To Be Published
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3EEF
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![BU of 3eef by Molmil](/molmil-images/mine/3eef) | Crystal structure of N-carbamoylsarcosine amidase from thermoplasma acidophilum | Descriptor: | N-carbamoylsarcosine amidase related protein, ZINC ION | Authors: | Luo, H.-B, Zheng, H, Chruszcz, M, Zimmerman, M.D, Skarina, T, Egorova, O, Savchenko, A, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2008-09-04 | Release date: | 2008-09-16 | Last modified: | 2022-04-13 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Crystal structure and molecular modeling study of N-carbamoylsarcosine amidase Ta0454 from Thermoplasma acidophilum. J.Struct.Biol., 169, 2010
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7UXG
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![BU of 7uxg by Molmil](/molmil-images/mine/7uxg) | Crystal structure of putative serine protease YdgD from Escherichia coli | Descriptor: | Serine protease | Authors: | Stogios, P.J, Michalska, K, Skarina, T, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2022-05-05 | Release date: | 2022-05-18 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | Crystal structure of putative serine protease YdgD from Escherichia coli To Be Published
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7V09
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![BU of 7v09 by Molmil](/molmil-images/mine/7v09) | Crystal structure of ECL_RS08780, putative sugar transport system periplasmic sugar-binding protein | Descriptor: | MAGNESIUM ION, Multiple sugar transport system periplasmic sugar-binding protein | Authors: | Stogios, P.J, Skarina, T, Mesa, N, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2022-05-10 | Release date: | 2022-05-18 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of ECL_RS08780, putative sugar transport system periplasmic sugar-binding protein To Be Published
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1YOX
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![BU of 1yox by Molmil](/molmil-images/mine/1yox) | Structure of the conserved Protein of Unknown Function PA3696 from Pseudomonas aeruginosa | Descriptor: | hypothetical protein PA3696 | Authors: | Walker, J.R, Xu, X, Gu, J, Joachimiak, A, Edwards, A, Savchenko, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2005-01-28 | Release date: | 2005-04-26 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | X-ray structure of the conserved hypothetical protein PA3696 To be Published
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5D5H
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![BU of 5d5h by Molmil](/molmil-images/mine/5d5h) | Crystal structure of Mycobacterium tuberculosis Topoisomerase I | Descriptor: | ACETATE ION, DNA topoisomerase 1, GLYCEROL, ... | Authors: | Tan, K, Cheng, B, Tse-Dinh, Y.C. | Deposit date: | 2015-08-10 | Release date: | 2015-12-16 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | Insights from the Structure of Mycobacterium tuberculosis Topoisomerase I with a Novel Protein Fold. J.Mol.Biol., 428, 2016
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1X7V
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![BU of 1x7v by Molmil](/molmil-images/mine/1x7v) | Crystal structure of PA3566 from Pseudomonas aeruginosa | Descriptor: | PA3566 protein, SULFATE ION | Authors: | Sanders, D.A, Walker, J.R, Skarina, T, Gorodichtchenskaia, E, Joachimiak, A, Edwards, A, Savchenko, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2004-08-16 | Release date: | 2004-08-31 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | The X-ray crystal structure of PA3566 from Pseudomonas aureginosa at 1.8 A resolution. Proteins, 61, 2005
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2P15
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![BU of 2p15 by Molmil](/molmil-images/mine/2p15) | Crystal structure of the ER alpha ligand binding domain with the agonist ortho-trifluoromethylphenylvinyl estradiol | Descriptor: | (17BETA)-17-{(E)-2-[2-(TRIFLUOROMETHYL)PHENYL]VINYL}ESTRA-1(10),2,4-TRIENE-3,17-DIOL, Estrogen receptor, GRIP peptide | Authors: | Bruning, J.B, Nettles, K.W, Greene, G.L, Kim, Y. | Deposit date: | 2007-03-02 | Release date: | 2007-05-01 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Structural plasticity in the oestrogen receptor ligand-binding domain. Embo Rep., 8, 2007
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