4O45
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![BU of 4o45 by Molmil](/molmil-images/mine/4o45) | WDR5 in complex with influenza NS1 C-terminal tail | Descriptor: | Nonstructural protein 1, UNKNOWN ATOM OR ION, WD repeat-containing protein 5 | Authors: | Qin, S, Xu, C, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2013-12-18 | Release date: | 2014-04-23 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Structural basis for histone mimicry and hijacking of host proteins by influenza virus protein NS1. Nat Commun, 5, 2014
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4QQ4
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![BU of 4qq4 by Molmil](/molmil-images/mine/4qq4) | CW-type zinc finger of MORC3 in complex with the amino terminus of histone H3 | Descriptor: | CHLORIDE ION, Histone H3.3, MORC family CW-type zinc finger protein 3, ... | Authors: | Liu, Y, Tempel, W, Dong, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2014-06-26 | Release date: | 2014-08-20 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Family-wide Characterization of Histone Binding Abilities of Human CW Domain-containing Proteins. J.Biol.Chem., 291, 2016
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4QQI
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![BU of 4qqi by Molmil](/molmil-images/mine/4qqi) | Crystal structure of ANKRA2-RFX7 complex | Descriptor: | Ankyrin repeat family A protein 2, DNA-binding protein RFX7, SULFATE ION, ... | Authors: | Xu, C, Tempel, W, Dong, A, Mackenzie, F, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2014-06-27 | Release date: | 2014-09-03 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Crystal structure of ANKRA2-RFX7 complex To Be Published
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4R3I
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![BU of 4r3i by Molmil](/molmil-images/mine/4r3i) | The crystal structure of an RNA complex | Descriptor: | RNA (5'-R(*GP*GP*(6MZ)P*CP*U)-3'), UNKNOWN ATOM OR ION, YTH domain-containing protein 1 | Authors: | Tempel, W, Xu, C, Liu, K, Li, Y, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2014-08-15 | Release date: | 2014-09-17 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis for selective binding of m(6)A RNA by the YTHDC1 YTH domain. Nat.Chem.Biol., 10, 2014
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4IKP
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![BU of 4ikp by Molmil](/molmil-images/mine/4ikp) | Crystal structure of coactivator-associated arginine methyltransferase 1 with methylenesinefungin | Descriptor: | (2S,5S)-2,6-diamino-5-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}hexanoic acid, GLYCEROL, Histone-arginine methyltransferase CARM1, ... | Authors: | Dong, A, Dombrovski, L, He, H, Ibanez, G, Wernimont, A, Zheng, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Min, J, Luo, M, Wu, H, Structural Genomics Consortium (SGC) | Deposit date: | 2012-12-27 | Release date: | 2013-02-13 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion. Elife, 8, 2019
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4RCM
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![BU of 4rcm by Molmil](/molmil-images/mine/4rcm) | Crystal structure of the Pho92 YTH domain in complex with m6A | Descriptor: | Methylated RNA-binding protein 1, RNA (5'-R(*UP*G)-D(*(6MZ)P*CP*U)-3'), UNKNOWN ATOM OR ION | Authors: | Tempel, W, Xu, C, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2014-09-16 | Release date: | 2014-11-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural Basis for the Discriminative Recognition of N6-Methyladenosine RNA by the Human YT521-B Homology Domain Family of Proteins. J.Biol.Chem., 290, 2015
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4ROJ
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![BU of 4roj by Molmil](/molmil-images/mine/4roj) | Crystal Structure of the VAV2 SH2 domain in complex with TXNIP phosphorylated peptide | Descriptor: | Guanine nucleotide exchange factor VAV2, Thioredoxin-interacting protein, UNKNOWN ATOM OR ION | Authors: | Liu, Y, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2014-10-28 | Release date: | 2014-12-10 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal Structure of the VAV2 SH2 domain in complex with TXNIP phosphorylated peptide TO BE PUBLISHED
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4II1
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![BU of 4ii1 by Molmil](/molmil-images/mine/4ii1) | Crystal structure of the zinc finger of ZGPAT | Descriptor: | UNKNOWN ATOM OR ION, ZINC ION, Zinc finger CCCH-type with G patch domain-containing protein | Authors: | Bian, C, Tempel, W, Dong, A, Chao, X, Fu, M, Wernimont, A.K, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2012-12-19 | Release date: | 2013-02-13 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Crystal structure of the zinc finger of ZGPAT to be published
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4PXW
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![BU of 4pxw by Molmil](/molmil-images/mine/4pxw) | Crystal structure of human DCAF1 WD40 repeats (Q1250L) | Descriptor: | Protein VPRBP, UNKNOWN ATOM OR ION | Authors: | Xu, C, Tempel, W, He, H, Li, Y, Walker, J.R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2014-03-25 | Release date: | 2014-04-16 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Crystal structure of human DCAF1 WD40 repeats (Q1250L) TO BE PUBLISHED
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4RXJ
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![BU of 4rxj by Molmil](/molmil-images/mine/4rxj) | crystal structure of WHSC1L1-PWWP2 | Descriptor: | Histone-lysine N-methyltransferase NSD3, UNKNOWN ATOM OR ION | Authors: | Qin, S, Tempel, W, Dong, A, Li, Y, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2014-12-11 | Release date: | 2015-01-28 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Histone and DNA binding ability studies of the NSD subfamily of PWWP domains. Biochem.Biophys.Res.Commun., 569, 2021
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3O70
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![BU of 3o70 by Molmil](/molmil-images/mine/3o70) | PHD-type zinc finger of human PHD finger protein 13 | Descriptor: | GLYCEROL, PHD finger protein 13, ZINC ION | Authors: | Lam, R, Bian, C.B, Xu, C, Kania, J, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2010-07-29 | Release date: | 2010-09-29 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | PHF13 is a molecular reader and transcriptional co-regulator of H3K4me2/3. Elife, 5, 2016
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2P0K
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![BU of 2p0k by Molmil](/molmil-images/mine/2p0k) | Crystal structure of SCMH1 | Descriptor: | CHLORIDE ION, PHOSPHATE ION, Polycomb protein SCMH1 | Authors: | Herzanych, N, Senisterra, G, Liu, Y, Crombet, L, Loppnau, P, Kozieradzki, I, Vedadi, M, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2007-02-28 | Release date: | 2007-03-27 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structure of SCMH1 To be Published
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2P0W
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![BU of 2p0w by Molmil](/molmil-images/mine/2p0w) | Human histone acetyltransferase 1 (HAT1) | Descriptor: | ACETAMIDE, ACETATE ION, ACETYL COENZYME *A, ... | Authors: | Wu, H, Min, J, Zeng, H, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2007-03-01 | Release date: | 2007-03-13 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The crystal structure of human histone acetyltransferase 1 (HAT1) in complex with acetylcoenzyme A and histone peptide H4 To be Published
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2QPW
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![BU of 2qpw by Molmil](/molmil-images/mine/2qpw) | Methyltransferase domain of human PR domain-containing protein 2 | Descriptor: | PR domain zinc finger protein 2 | Authors: | Lunin, V.V, Wu, H, Dombrovski, L, Antoshenko, T, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Plotnikov, A.N, Structural Genomics Consortium (SGC) | Deposit date: | 2007-07-25 | Release date: | 2007-08-14 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Structural biology of human H3K9 methyltransferases Plos One, 5, 2010
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2R3A
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![BU of 2r3a by Molmil](/molmil-images/mine/2r3a) | Methyltransferase domain of human suppressor of variegation 3-9 homolog 2 | Descriptor: | Histone-lysine N-methyltransferase SUV39H2, S-ADENOSYLMETHIONINE, SERINE, ... | Authors: | Lunin, V.V, Wu, H, Zeng, H, Ren, H, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2007-08-29 | Release date: | 2007-09-11 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural biology of human H3K9 methyltransferases Plos One, 5, 2010
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2L11
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![BU of 2l11 by Molmil](/molmil-images/mine/2l11) | Solution NMR structure of the Cbx3 in complex with H3K9me3 peptide | Descriptor: | Chromobox protein homolog 3, Histone H3 | Authors: | Kaustov, L, Lemak, A, Fares, C, Gutmanas, A, Quang, H, Loppnau, P, Min, J, Edwards, A, Arrowsmith, C, Structural Genomics Consortium (SGC) | Deposit date: | 2010-07-22 | Release date: | 2010-08-04 | Last modified: | 2020-02-05 | Method: | SOLUTION NMR | Cite: | Recognition and specificity determinants of the human cbx chromodomains. J.Biol.Chem., 286, 2011
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2L1B
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![BU of 2l1b by Molmil](/molmil-images/mine/2l1b) | Solution NMR structure of the chromobox protein Cbx7 with H3K27me3 | Descriptor: | Chromobox protein homolog 7, Histone H3 | Authors: | Kaustov, L, Lemak, A, Fares, C, Gutmanas, A, Muhandiram, R, Quang, H, Loppnau, P, Min, J, Edwards, A, Arrowsmith, C, Structural Genomics Consortium (SGC) | Deposit date: | 2010-07-27 | Release date: | 2010-08-25 | Last modified: | 2020-02-05 | Method: | SOLUTION NMR | Cite: | Recognition and specificity determinants of the human cbx chromodomains. J.Biol.Chem., 286, 2011
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2LLK
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![BU of 2llk by Molmil](/molmil-images/mine/2llk) | Solution NMR structure of the N-terminal myb-like 1 domain of the human cyclin-D-binding transcription factor 1 (hDMP1), Northeast Structural Genomics Consortium (NESG) target ID hr8011a | Descriptor: | Cyclin-D-binding Myb-like transcription factor 1 | Authors: | Montecchio, M, Lemak, A, Yee, A, Xu, C, Garcia, M, Houliston, S, Min, J, Bellanda, M, Montelione, G.T, Arrowsmith, C, Northeast Structural Genomics Consortium (NESG), Structural Genomics Consortium (SGC) | Deposit date: | 2011-11-10 | Release date: | 2011-11-23 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution NMR structure of the N-terminal myb-like 1 domain of the human cyclin D binding transcription factor 1 (hDMP1). To be Published
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2LLL
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![BU of 2lll by Molmil](/molmil-images/mine/2lll) | Solution NMR structure of C-terminal globular domain of human Lamin-B2, Northeast Structural Genomics Consortium target HR8546A | Descriptor: | Lamin-B2 | Authors: | Lemak, A, Yee, A, Houliston, S, Garcia, M, Xu, C, Min, J, Montelione, G.T, Arrowsmith, C, Northeast Structural Genomics Consortium (NESG), Structural Genomics Consortium (SGC), Chaperone-Enabled Studies of Epigenetic Regulation Enzymes (CEBS) | Deposit date: | 2011-11-11 | Release date: | 2011-12-07 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | NMR solution structure of c-terminal globular domain of human Lamin-B2 To be Published
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2LV9
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![BU of 2lv9 by Molmil](/molmil-images/mine/2lv9) | Solution NMR structure of the PHD domain of human MLL5, Northeast structural genomics consortium target HR6512A | Descriptor: | Histone-lysine N-methyltransferase MLL5, ZINC ION | Authors: | Lemak, A, Yee, A, Houliston, S, Garcia, M, Wu, H, Min, J, Montelione, G.T, Arrowsmith, C, Northeast Structural Genomics Consortium (NESG), Structural Genomics Consortium (SGC), Chaperone-Enabled Studies of Epigenetic Regulation Enzymes (CEBS) | Deposit date: | 2012-06-29 | Release date: | 2012-09-05 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | NMR solution structure of the human MLL5 PHD domain (CASP Target) To be Published
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3LYI
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![BU of 3lyi by Molmil](/molmil-images/mine/3lyi) | PWWP Domain of Human Bromodomain-Containing Protein 1 | Descriptor: | Bromodomain-containing protein 1, CYSTEINESULFONIC ACID | Authors: | Lam, R, Zeng, H, Ni, S, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Wu, H, Structural Genomics Consortium (SGC) | Deposit date: | 2010-02-26 | Release date: | 2010-03-16 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural and histone binding ability characterizations of human PWWP domains. Plos One, 6, 2011
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4HAE
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![BU of 4hae by Molmil](/molmil-images/mine/4hae) | Crystal structure of the CDYL2-chromodomain | Descriptor: | Chromodomain Y-like protein 2, SULFATE ION, UNKNOWN ATOM OR ION | Authors: | Qin, S, Dombrovski, L, Tempel, W, Dong, A, Xu, C, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Wu, H, Structural Genomics Consortium (SGC) | Deposit date: | 2012-09-26 | Release date: | 2012-10-10 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of the CDYL2-chromodomain To be Published
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3K26
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![BU of 3k26 by Molmil](/molmil-images/mine/3k26) | Complex structure of EED and trimethylated H3K4 | Descriptor: | HISTONE PEPTIDE, Polycomb protein EED | Authors: | Bian, C.B, Xu, C, Qiu, W, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2009-09-29 | Release date: | 2009-12-15 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2). Proc.Natl.Acad.Sci.USA, 107, 2010
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3JZH
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![BU of 3jzh by Molmil](/molmil-images/mine/3jzh) | EED-H3K79me3 | Descriptor: | HISTONE PEPTIDE, Polycomb protein EED | Authors: | Xu, C, Bian, C.B, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2009-09-23 | Release date: | 2009-12-15 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2). Proc.Natl.Acad.Sci.USA, 107, 2010
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3MO8
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![BU of 3mo8 by Molmil](/molmil-images/mine/3mo8) | PWWP Domain of Human Bromodomain and PHD finger-containing protein 1 In Complex with Trimethylated H3K36 Peptide | Descriptor: | Histone H3.2 TRIMETHYLATED H3K36 PEPTIDE, Peregrin | Authors: | Lam, R, Zeng, H, Ni, S, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Wu, H, Structural Genomics Consortium (SGC) | Deposit date: | 2010-04-22 | Release date: | 2010-06-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Structural and Histone Binding Ability Characterizations of Human PWWP Domains. Plos One, 6, 2011
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