3OJA
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![BU of 3oja by Molmil](/molmil-images/mine/3oja) | Crystal structure of LRIM1/APL1C complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Anopheles Plasmodium-responsive Leucine-rich repeat protein 1, ... | Authors: | Baxter, R.H.G, Deisenhofer, J. | Deposit date: | 2010-08-20 | Release date: | 2010-09-22 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | A heterodimeric complex of the LRR proteins LRIM1 and APL1C regulates complement-like immunity in Anopheles gambiae. Proc.Natl.Acad.Sci.USA, 107, 2010
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5XIM
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![BU of 5xim by Molmil](/molmil-images/mine/5xim) | |
1K3Z
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![BU of 1k3z by Molmil](/molmil-images/mine/1k3z) | X-ray crystal structure of the IkBb/NF-kB p65 homodimer complex | Descriptor: | Transcription factor p65, transcription factor inhibitor I-kappa-B-beta | Authors: | Shiva, M, Huang, D.B, Chen, Y, Huxford, T, Ghosh, S, Ghosh, G. | Deposit date: | 2001-10-04 | Release date: | 2002-10-04 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | X-ray crystal structure of an IkappaBbeta x NF-kappaB p65 homodimer complex. J.Biol.Chem., 278, 2003
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3SQO
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![BU of 3sqo by Molmil](/molmil-images/mine/3sqo) | PCSK9 J16 Fab complex | Descriptor: | J16 Heavy chain, J16 Light chain, PCSK9 prodomain, ... | Authors: | Strop, P. | Deposit date: | 2011-07-05 | Release date: | 2012-05-16 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Proprotein convertase substilisin/kexin type 9 antagonism reduces low-density lipoprotein cholesterol in statin-treated hypercholesterolemic nonhuman primates. J.Pharmacol.Exp.Ther., 340, 2012
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3GIM
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![BU of 3gim by Molmil](/molmil-images/mine/3gim) | Dpo4 extension ternary complex with oxoG(anti)-G(syn) pair | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 5'-D(*CP*TP*AP*AP*CP*(8OG)P*CP*TP*AP*CP*CP*AP*TP*CP*CP*AP*AP*C)-3', 5'-D(*GP*TP*TP*GP*GP*AP*TP*GP*GP*TP*AP*GP*(DDG))-3', ... | Authors: | Rechkoblit, O, Malinina, L, Patel, D.J. | Deposit date: | 2009-03-05 | Release date: | 2009-05-19 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Impact of conformational heterogeneity of OxoG lesions and their pairing partners on bypass fidelity by Y family polymerases. Structure, 17, 2009
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5XIN
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![BU of 5xin by Molmil](/molmil-images/mine/5xin) | |
3GIK
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![BU of 3gik by Molmil](/molmil-images/mine/3gik) | Dpo4 extension ternary complex with the oxoG(anti)-C(anti) pair | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 5'-D(*CP*TP*AP*AP*CP*(8OG)P*CP*TP*AP*CP*CP*AP*TP*CP*CP*AP*AP*C)-3', 5'-D(*GP*TP*TP*GP*GP*AP*TP*GP*GP*TP*AP*GP*(DOC))-3', ... | Authors: | Rechkoblit, O, Malinina, L, Patel, D.J. | Deposit date: | 2009-03-05 | Release date: | 2009-05-19 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Impact of conformational heterogeneity of OxoG lesions and their pairing partners on bypass fidelity by Y family polymerases. Structure, 17, 2009
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3GIJ
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![BU of 3gij by Molmil](/molmil-images/mine/3gij) | Dpo4 extension ternary complex with oxoG(syn)-A(anti) and oxoG(anti)-A(syn) pairs | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 5'-D(*CP*TP*AP*AP*CP*(8OG)P*CP*TP*AP*CP*CP*AP*TP*CP*CP*AP*AP*C)-3', 5'-D(*GP*TP*TP*GP*GP*AP*TP*GP*GP*TP*AP*GP*(2DA))-3', ... | Authors: | Rechkoblit, O, Malinina, L, Patel, D.J. | Deposit date: | 2009-03-05 | Release date: | 2009-05-19 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Impact of conformational heterogeneity of OxoG lesions and their pairing partners on bypass fidelity by Y family polymerases. Structure, 17, 2009
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3GII
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![BU of 3gii by Molmil](/molmil-images/mine/3gii) | Dpo4 extension ternary complex with disordered A opposite an oxoG in anti conformation | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 5'-D(*CP*TP*AP*AP*CP*(8OG)P*CP*TP*AP*CP*CP*AP*TP*CP*CP*AP*AP*CP*C)-3', 5'-D(*GP*TP*TP*GP*GP*AP*TP*GP*GP*TP*AP*GP*(2DA))-3', ... | Authors: | Rechkoblit, O, Malinina, L, Patel, D.J. | Deposit date: | 2009-03-05 | Release date: | 2009-05-19 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Impact of conformational heterogeneity of OxoG lesions and their pairing partners on bypass fidelity by Y family polymerases. Structure, 17, 2009
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3GIL
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![BU of 3gil by Molmil](/molmil-images/mine/3gil) | Dpo4 extension ternary complex with oxoG(anti)-T(anti) pair | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, 5'-D(*CP*TP*AP*AP*CP*(8OG)P*CP*TP*AP*CP*CP*AP*TP*CP*CP*AP*AP*C)-3', 5'-D(*GP*TP*TP*GP*GP*AP*TP*GP*GP*TP*AP*GP*(2DT))-3', ... | Authors: | Rechkoblit, O, Malinina, L, Patel, D.J. | Deposit date: | 2009-03-05 | Release date: | 2009-05-19 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | Impact of conformational heterogeneity of OxoG lesions and their pairing partners on bypass fidelity by Y family polymerases. Structure, 17, 2009
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4LWS
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![BU of 4lws by Molmil](/molmil-images/mine/4lws) | EsxA : EsxB (SeMet) hetero-dimer from Thermomonospora curvata | Descriptor: | ACETATE ION, GLYCEROL, Uncharacterized protein | Authors: | Dovala, D.L, Cox, J.S, Stroud, R.M, Rosenberg, O.S. | Deposit date: | 2013-07-28 | Release date: | 2015-02-04 | Last modified: | 2016-09-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Substrates Control Multimerization and Activation of the Multi-Domain ATPase Motor of Type VII Secretion. Cell(Cambridge,Mass.), 161, 2015
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7JV9
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![BU of 7jv9 by Molmil](/molmil-images/mine/7jv9) | Human CD73 (ecto 5'-nucleotidase) in complex with compound 12 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5'-nucleotidase, 6-chloro-N-[(2-chlorophenyl)methyl]-1-[5-O-(phosphonomethyl)-beta-D-ribofuranosyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine, ... | Authors: | Gibbons, P, Du, X. | Deposit date: | 2020-08-20 | Release date: | 2020-09-23 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Orally Bioavailable Small-Molecule CD73 Inhibitor (OP-5244) Reverses Immunosuppression through Blockade of Adenosine Production. J.Med.Chem., 63, 2020
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7JV8
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![BU of 7jv8 by Molmil](/molmil-images/mine/7jv8) | Human CD73 (ecto 5'-nucleotidase) in complex with compound 35 | Descriptor: | 5'-nucleotidase, 6-chloro-N-cyclopentyl-1-{5-O-[(2R)-1-hydroxy-3-methoxy-2-phosphonopropan-2-yl]-beta-D-ribofuranosyl}-1H-pyrazolo[3,4-d]pyrimidin-4-amine, CALCIUM ION, ... | Authors: | Gibbons, P, Du, X. | Deposit date: | 2020-08-20 | Release date: | 2020-09-23 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | Orally Bioavailable Small-Molecule CD73 Inhibitor (OP-5244) Reverses Immunosuppression through Blockade of Adenosine Production. J.Med.Chem., 63, 2020
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4LYA
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![BU of 4lya by Molmil](/molmil-images/mine/4lya) | EssC (ATPases 2 and 3) from Geobacillus thermodenitrificans (SeMet) | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Uncharacterized protein | Authors: | Dovala, D.L, Bendebury, A, Cox, J.S, Stroud, R.M, Rosenberg, O.S. | Deposit date: | 2013-07-30 | Release date: | 2015-02-04 | Last modified: | 2016-09-21 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Substrates Control Multimerization and Activation of the Multi-Domain ATPase Motor of Type VII Secretion. Cell(Cambridge,Mass.), 161, 2015
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2PN5
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![BU of 2pn5 by Molmil](/molmil-images/mine/2pn5) | Crystal Structure of TEP1r | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, ... | Authors: | Baxter, R.H.G. | Deposit date: | 2007-04-23 | Release date: | 2007-07-24 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.698 Å) | Cite: | Structural basis for conserved complement factor-like function in the antimalarial protein TEP1 Proc.Natl.Acad.Sci.Usa, 104, 2007
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4N1A
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![BU of 4n1a by Molmil](/molmil-images/mine/4n1a) | Thermomonospora curvata EccC (ATPases 2 and 3) in complex with a signal sequence peptide | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cell divisionFtsK/SpoIIIE, MAGNESIUM ION, ... | Authors: | Dovala, D.L, Bendebury, A, Cox, J.S, Stroud, R.M, Rosenberg, O.S. | Deposit date: | 2013-10-03 | Release date: | 2015-02-11 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.24 Å) | Cite: | Substrates Control Multimerization and Activation of the Multi-Domain ATPase Motor of Type VII Secretion. Cell(Cambridge,Mass.), 161, 2015
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4NH0
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![BU of 4nh0 by Molmil](/molmil-images/mine/4nh0) | Cytoplasmic domain of the Thermomonospora curvata Type VII Secretion ATPase EccC | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cell divisionFtsK/SpoIIIE, MAGNESIUM ION, ... | Authors: | Rosenberg, O.S, Cox, J.S, Stroud, R.M, Strauli, N, Dovala, D. | Deposit date: | 2013-11-03 | Release date: | 2015-02-11 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Substrates Control Multimerization and Activation of the Multi-Domain ATPase Motor of Type VII Secretion. Cell(Cambridge,Mass.), 161, 2015
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7KWA
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![BU of 7kwa by Molmil](/molmil-images/mine/7kwa) | Structure of DCN1 bound to N-((4S,5S)-3-(aminomethyl)-7-ethyl-4-(4-fluorophenyl)-6-oxo-1-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl)-3-(trifluoromethyl)benzamide | Descriptor: | Endolysin,DCN1-like protein 1, N-[(4S,5S)-3-(aminomethyl)-7-ethyl-4-(4-fluorophenyl)-6-oxo-1-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl]-3-(trifluoromethyl)benzamide | Authors: | Kim, H.S, Hammill, J.T, Schulman, B.A, Guy, R.K, Scott, D.C. | Deposit date: | 2020-11-30 | Release date: | 2021-07-14 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.572 Å) | Cite: | Improvement of Oral Bioavailability of Pyrazolo-Pyridone Inhibitors of the Interaction of DCN1/2 and UBE2M. J.Med.Chem., 64, 2021
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7BYI
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![BU of 7byi by Molmil](/molmil-images/mine/7byi) | Structure of SHMT2 in complex with CBX | Descriptor: | CARBENOXOLONE, DI(HYDROXYETHYL)ETHER, PHOSPHATE ION, ... | Authors: | Li, L, Chen, Y, Lu, D, Zhang, C, Su, D. | Deposit date: | 2020-04-23 | Release date: | 2021-09-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.76 Å) | Cite: | Structure of SHMT2 with CBX To Be Published
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2XIN
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![BU of 2xin by Molmil](/molmil-images/mine/2xin) | |
7LT2
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![BU of 7lt2 by Molmil](/molmil-images/mine/7lt2) | |
7LT1
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![BU of 7lt1 by Molmil](/molmil-images/mine/7lt1) | |
5T5X
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![BU of 5t5x by Molmil](/molmil-images/mine/5t5x) | |
7LJY
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![BU of 7ljy by Molmil](/molmil-images/mine/7ljy) | Cryo-EM structure of the B dENE construct complexed with a 28-mer poly(A) | Descriptor: | B dENE construct, poly(A) | Authors: | Torabi, S, Chen, Y, Zhang, K, Wang, J, DeGregorio, S, Vaidya, A, Su, Z, Pabit, S, Chiu, W, Pollack, L, Steitz, J. | Deposit date: | 2021-02-01 | Release date: | 2021-04-14 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (5.6 Å) | Cite: | Structural analyses of an RNA stability element interacting with poly(A). Proc.Natl.Acad.Sci.USA, 118, 2021
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