3DCK
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![BU of 3dck by Molmil](/molmil-images/mine/3dck) | X-ray structure of D25N chemical analogue of HIV-1 protease complexed with ketomethylene isostere inhibitor | Descriptor: | (2S)-2-{[(2R,5S)-5-{[(2S,3S)-2-{[(2S,3R)-2-(acetylamino)-3-hydroxybutanoyl]amino}-3-methylpentanoyl]amino}-2-butyl-4-oxononanoyl]amino}-N~1~-[(2S)-1-amino-5-carbamimidamido-1-oxopentan-2-yl]pentanediamide, Chemical analogue HIV-1 protease | Authors: | Torbeev, V.Y, Mandal, K, Terechko, V.A, Kent, S.B.H. | Deposit date: | 2008-06-03 | Release date: | 2008-08-19 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of chemically synthesized HIV-1 protease and a ketomethylene isostere inhibitor based on the p2/NC cleavage site Bioorg.Med.Chem.Lett., 18, 2008
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3DCR
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![BU of 3dcr by Molmil](/molmil-images/mine/3dcr) | X-ray structure of HIV-1 protease and hydrated form of ketomethylene isostere inhibitor | Descriptor: | Chemical analogue HIV-1 protease, N~2~-[(2R,5S)-5-({(2S,3S)-2-[(N-acetyl-L-threonyl)amino]-3-methylpent-4-enoyl}amino)-2-butyl-4,4-dihydroxynonanoyl]-L-glutaminyl-L-argininamide | Authors: | Torbeev, V.Y, Mandal, K, Terechko, V.A, Kent, S.B.H. | Deposit date: | 2008-06-04 | Release date: | 2008-08-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Crystal structure of chemically synthesized HIV-1 protease and a ketomethylene isostere inhibitor based on the p2/NC cleavage site Bioorg.Med.Chem.Lett., 18, 2008
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2O40
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![BU of 2o40 by Molmil](/molmil-images/mine/2o40) | |
3KA2
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![BU of 3ka2 by Molmil](/molmil-images/mine/3ka2) | |
3NWQ
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![BU of 3nwq by Molmil](/molmil-images/mine/3nwq) | |
3NXE
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![BU of 3nxe by Molmil](/molmil-images/mine/3nxe) | |
3NWX
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![BU of 3nwx by Molmil](/molmil-images/mine/3nwx) | X-ray structure of ester chemical analogue [O-Ile50,O-Ile50']HIV-1 protease complexed with KVS-1 inhibitor | Descriptor: | N~2~-[(2R,5S)-5-({(2S,3S)-2-[(N-acetyl-L-threonyl)amino]-3-methylpent-4-enoyl}amino)-2-butyl-4,4-dihydroxynonanoyl]-L-glutaminyl-L-argininamide, SULFATE ION, protease | Authors: | Torbeev, V.Y, Kent, S.B.H. | Deposit date: | 2010-07-12 | Release date: | 2011-11-02 | Last modified: | 2019-07-31 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Protein conformational dynamics in the mechanism of HIV-1 protease catalysis. Proc.Natl.Acad.Sci.USA, 108, 2011
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3NXN
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![BU of 3nxn by Molmil](/molmil-images/mine/3nxn) | X-ray structure of ester chemical analogue 'covalent dimer' [Ile50,O-Ile50']HIV-1 protease complexed with KVS-1 inhibitor | Descriptor: | N~2~-[(2R,5S)-5-({(2S,3S)-2-[(N-acetyl-L-threonyl)amino]-3-methylpent-4-enoyl}amino)-2-butyl-4,4-dihydroxynonanoyl]-L-glutaminyl-L-argininamide, SULFATE ION, protease covalent dimer | Authors: | Torbeev, V.Y, Kent, S.B.H. | Deposit date: | 2010-07-14 | Release date: | 2011-11-02 | Last modified: | 2019-07-31 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Protein conformational dynamics in the mechanism of HIV-1 protease catalysis. Proc.Natl.Acad.Sci.USA, 108, 2011
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3NYG
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![BU of 3nyg by Molmil](/molmil-images/mine/3nyg) | |
3HZC
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![BU of 3hzc by Molmil](/molmil-images/mine/3hzc) | |
3HLO
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![BU of 3hlo by Molmil](/molmil-images/mine/3hlo) | |
3FSM
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![BU of 3fsm by Molmil](/molmil-images/mine/3fsm) | |
3GI0
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![BU of 3gi0 by Molmil](/molmil-images/mine/3gi0) | |
3HAW
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![BU of 3haw by Molmil](/molmil-images/mine/3haw) | |
3I2L
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![BU of 3i2l by Molmil](/molmil-images/mine/3i2l) | |
3IAW
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![BU of 3iaw by Molmil](/molmil-images/mine/3iaw) | |
3HAU
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![BU of 3hau by Molmil](/molmil-images/mine/3hau) | |
3HBO
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![BU of 3hbo by Molmil](/molmil-images/mine/3hbo) | Crystal structure of chemically synthesized [D-Ala51/51']HIV-1 protease | Descriptor: | N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide, [D-Ala51/51']HIV-1 protease | Authors: | Torbeev, V.Y, Kent, S.B.H. | Deposit date: | 2009-05-04 | Release date: | 2010-05-26 | Last modified: | 2012-12-12 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Protein conformational dynamics in the mechanism of HIV-1 protease catalysis. Proc.Natl.Acad.Sci.USA, 108, 2011
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3HDK
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![BU of 3hdk by Molmil](/molmil-images/mine/3hdk) | Crystal structure of chemically synthesized [Aib51/51']HIV-1 protease | Descriptor: | N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide, [Aib51/51']HIV-1 protease | Authors: | Torbeev, V.Y, Kent, S.B.H. | Deposit date: | 2009-05-07 | Release date: | 2010-04-28 | Last modified: | 2012-12-12 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Protein conformational dynamics in the mechanism of HIV-1 protease catalysis. Proc.Natl.Acad.Sci.USA, 108, 2011
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3IA9
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![BU of 3ia9 by Molmil](/molmil-images/mine/3ia9) | |
3UE7
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![BU of 3ue7 by Molmil](/molmil-images/mine/3ue7) | X-ray crystal structure of a novel topological analogue of crambin | Descriptor: | Crambin, D-Crambin | Authors: | Mandal, K, Pentelute, B.L, Bang, D, Gates, Z.P, Torbeev, V.Y, Kent, S.B.H. | Deposit date: | 2011-10-28 | Release date: | 2012-02-08 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.08 Å) | Cite: | Design, total chemical synthesis, and x-ray structure of a protein having a novel linear-loop polypeptide chain topology. Angew.Chem.Int.Ed.Engl., 51, 2012
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2NWD
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![BU of 2nwd by Molmil](/molmil-images/mine/2nwd) | |