3HAU
Crystal structure of chemically synthesized HIV-1 protease with reduced isostere MVT-101 inhibitor
Summary for 3HAU
| Entry DOI | 10.2210/pdb3hau/pdb |
| Related | 3FSM 3GI0 |
| Related PRD ID | PRD_000398 |
| Descriptor | HIV-1 protease, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide, SULFATE ION, ... (4 entities in total) |
| Functional Keywords | beta barrel, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Total number of polymer chains | 2 |
| Total formula weight | 22302.25 |
| Authors | Torbeev, V.Y.,Kent, S.B.H. (deposition date: 2009-05-02, release date: 2011-04-27, Last modification date: 2012-12-12) |
| Primary citation | Torbeev, V.Y.,Raghuraman, H.,Hamelberg, D.,Tonelli, M.,Westler, W.M.,Perozo, E.,Kent, S.B. Protein conformational dynamics in the mechanism of HIV-1 protease catalysis. Proc.Natl.Acad.Sci.USA, 108:20982-20987, 2011 Cited by PubMed: 22158985DOI: 10.1073/pnas.1111202108 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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