3HDK

Crystal structure of chemically synthesized [Aib51/51']HIV-1 protease

Summary for 3HDK

Entry DOI	10.2210/pdb3hdk/pdb
Related	3FSM 3GI0 3HAU 3HAW
Related PRD ID	PRD_000398
Descriptor	[Aib51/51']HIV-1 protease, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide (3 entities in total)
Functional Keywords	beta barrel, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Total number of polymer chains	2
Total formula weight	22262.29
Authors	Torbeev, V.Y.,Kent, S.B.H. (deposition date: 2009-05-07, release date: 2010-04-28, Last modification date: 2012-12-12)
Primary citation	Torbeev, V.Y.,Raghuraman, H.,Hamelberg, D.,Tonelli, M.,Westler, W.M.,Perozo, E.,Kent, S.B. Protein conformational dynamics in the mechanism of HIV-1 protease catalysis. Proc.Natl.Acad.Sci.USA, 108:20982-20987, 2011 Cited by PubMed: 22158985 DOI: 10.1073/pnas.1111202108 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation