7VQF
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![BU of 7vqf by Molmil](/molmil-images/mine/7vqf) | Phenol binding protein, MopR | Descriptor: | ACETATE ION, PHENOL, Phenol sensing regulator, ... | Authors: | Singh, J, Ray, S, Anand, R. | Deposit date: | 2021-10-19 | Release date: | 2022-09-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Phenol sensing in nature is modulated via a conformational switch governed by dynamic allostery. J.Biol.Chem., 298, 2022
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7ENU
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![BU of 7enu by Molmil](/molmil-images/mine/7enu) | Crystal structure of iron-saturated C-terminal half of lactoferrin produced proteolytically using pepsin at 2.32A resolution | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CARBONATE ION, FE (III) ION, ... | Authors: | Singh, J, Maurya, A, Viswanathan, V, Singh, P.K, Sharma, P, Sharma, S, Singh, T.P. | Deposit date: | 2021-04-19 | Release date: | 2021-05-19 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.322 Å) | Cite: | Crystal structure of iron-saturated C-terminal half of lactoferrin produced proteolytically using pepsin at 2.32A resolution To Be Published
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7EV0
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![BU of 7ev0 by Molmil](/molmil-images/mine/7ev0) | Crystal structure of pepsin cleaved C-terminal half of lactoferrin at 2.7A resolution | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CARBONATE ION, ... | Authors: | Singh, J, Ahmad, M.I, Maurya, A, Sharma, P, Sharma, S, Singh, T.P. | Deposit date: | 2021-05-19 | Release date: | 2021-06-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of pepsin cleaved C-terminal half of lactoferrin at 2.7A resolution To Be Published
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7C3T
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![BU of 7c3t by Molmil](/molmil-images/mine/7c3t) | Crystal structure of NE0047 (N66Q) mutant in complex with 8-azaguanine | Descriptor: | 5-AMINO-1H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDIN-7-OL, Cytidine and deoxycytidylate deaminase zinc-binding region, ZINC ION | Authors: | Gaded, V, Bitra, A, Singh, J, Anand, R. | Deposit date: | 2020-05-14 | Release date: | 2021-05-26 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Structure guided mutagenesis reveals the substrate determinants of guanine deaminase. J.Struct.Biol., 213, 2021
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7C3U
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![BU of 7c3u by Molmil](/molmil-images/mine/7c3u) | Crystal structure of NE0047 (N66A) mutant in complex with 8-azaguanine | Descriptor: | 1,2-ETHANEDIOL, 5-AMINO-1H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDIN-7-OL, Cytidine and deoxycytidylate deaminase zinc-binding region, ... | Authors: | Gaded, V, Bitra, A, Singh, J, Anand, R. | Deposit date: | 2020-05-14 | Release date: | 2021-05-26 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Structure guided mutagenesis reveals the substrate determinants of guanine deaminase. J.Struct.Biol., 213, 2021
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7C3S
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![BU of 7c3s by Molmil](/molmil-images/mine/7c3s) | Crystal structure of NE0047 (E143D) mutant in complex with 8-azaguanine | Descriptor: | 1,2-ETHANEDIOL, 5-AMINO-1H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDIN-7-OL, Cytidine and deoxycytidylate deaminase zinc-binding region, ... | Authors: | Gaded, V, Bitra, A, Singh, J, Anand, R. | Deposit date: | 2020-05-14 | Release date: | 2021-05-26 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Structure guided mutagenesis reveals the substrate determinants of guanine deaminase. J.Struct.Biol., 213, 2021
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7V2Q
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![BU of 7v2q by Molmil](/molmil-images/mine/7v2q) | T.thermophilus 30S ribosome with KsgA, class K6 | Descriptor: | 16s ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | Authors: | Raina, R, Singh, J, Anand, R, Vinothkumar, K.R. | Deposit date: | 2021-08-09 | Release date: | 2022-04-06 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.24 Å) | Cite: | Decoding the Mechanism of Specific RNA Targeting by Ribosomal Methyltransferases. Acs Chem.Biol., 17, 2022
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7V2N
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![BU of 7v2n by Molmil](/molmil-images/mine/7v2n) | T.thermophilus 30S ribosome with KsgA, class K2 | Descriptor: | 16s ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | Authors: | Raina, R, Singh, J, Anand, R, Vinothkumar, K.R. | Deposit date: | 2021-08-09 | Release date: | 2022-04-06 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Decoding the Mechanism of Specific RNA Targeting by Ribosomal Methyltransferases. Acs Chem.Biol., 17, 2022
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7V2M
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![BU of 7v2m by Molmil](/molmil-images/mine/7v2m) | T.thermophilus 30S ribosome with KsgA, class K1k4 | Descriptor: | 16s ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | Authors: | Raina, R, Singh, J, Anand, R, Vinothkumar, K.R. | Deposit date: | 2021-08-09 | Release date: | 2022-04-06 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Decoding the Mechanism of Specific RNA Targeting by Ribosomal Methyltransferases. Acs Chem.Biol., 17, 2022
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7V2O
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![BU of 7v2o by Molmil](/molmil-images/mine/7v2o) | T.thermophilus 30S ribosome with KsgA, class K4 | Descriptor: | 16s ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | Authors: | Raina, R, Singh, J, Anand, R, Vinothkumar, K.R. | Deposit date: | 2021-08-09 | Release date: | 2022-04-06 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Decoding the Mechanism of Specific RNA Targeting by Ribosomal Methyltransferases. Acs Chem.Biol., 17, 2022
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7V2L
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![BU of 7v2l by Molmil](/molmil-images/mine/7v2l) | T.thermophilus 30S ribosome with KsgA, class K1k2 | Descriptor: | 16s ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | Authors: | Raina, R, Singh, J, Anand, R, Vinothkumar, K.R. | Deposit date: | 2021-08-09 | Release date: | 2022-04-06 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Decoding the Mechanism of Specific RNA Targeting by Ribosomal Methyltransferases. Acs Chem.Biol., 17, 2022
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7V2P
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![BU of 7v2p by Molmil](/molmil-images/mine/7v2p) | T.thermophilus 30S ribosome with KsgA, class K5 | Descriptor: | 16s ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | Authors: | Raina, R, Singh, J, Anand, R, Vinothkumar, K.R. | Deposit date: | 2021-08-09 | Release date: | 2022-04-06 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Decoding the Mechanism of Specific RNA Targeting by Ribosomal Methyltransferases. Acs Chem.Biol., 17, 2022
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7FDW
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![BU of 7fdw by Molmil](/molmil-images/mine/7fdw) | Crystal structure of pepsin cleaved lactoferrin C-lobe at 2.28 A resolution | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CARBONATE ION, FE (III) ION, ... | Authors: | Singh, P.K, Singh, J, Maurya, A, Sharma, P, Sharma, S, Singh, T.P. | Deposit date: | 2021-07-18 | Release date: | 2021-08-04 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.277 Å) | Cite: | A Peptide Bond from the Inter-lobe Segment in the Bilobal Lactoferrin Acts as a Preferred Site for Cleavage for Serine Proteases to Generate the Perfect C-lobe: Structure of the Pepsin Hydrolyzed Lactoferrin C-lobe at 2.28 angstrom Resolution. Protein J., 40, 2021
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3ZIM
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![BU of 3zim by Molmil](/molmil-images/mine/3zim) | Discovery of a potent and isoform-selective targeted covalent inhibitor of the lipid kinase PI3Kalpha | Descriptor: | 1-[4-[[2-(1H-indazol-4-yl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-6-methyl-hept-5-ene-1,4- dione, PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM | Authors: | Nacht, M, Qiao, L, Sheets, M.P, Martin, T.S, Labenski, M, Mazdiyasni, H, Karp, R, Zhu, Z, Chaturvedi, P, Bhavsar, D, Niu, D, Westlin, W, Petter, R.C, Medikonda, A.P, Jestel, A, Blaesse, M, Singh, J. | Deposit date: | 2013-01-09 | Release date: | 2013-02-13 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Discovery of a Potent and Isoform-Selective Targeted Covalent Inhibitor of the Lipid Kinase Pi3Kalpha J.Med.Chem., 56, 2013
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3OD7
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![BU of 3od7 by Molmil](/molmil-images/mine/3od7) | Haemophilus influenzae ferric binding protein A -Iron Loaded | Descriptor: | FE (III) ION, Iron-utilization periplasmic protein, PHOSPHATE ION | Authors: | Khambati, H.K, Moraes, T.F, Singh, J, Shouldice, S.R, Yu, R.H, Schryvers, A.B. | Deposit date: | 2010-08-11 | Release date: | 2010-09-15 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.801 Å) | Cite: | The role of vicinal tyrosine residues in the function of Haemophilus influenzae ferric binding protein A. Biochem.J., 2010
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3ODB
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![BU of 3odb by Molmil](/molmil-images/mine/3odb) | Haemophilus influenzae ferric binding protein A -Iron Loaded -open Conformation | Descriptor: | FE (III) ION, Iron-utilization periplasmic protein | Authors: | Khambati, H.K, Moraes, T.F, Singh, J, Shouldice, S.R, Yu, R.H, Schryvers, A.B. | Deposit date: | 2010-08-11 | Release date: | 2010-09-15 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | The role of vicinal tyrosine residues in the function of Haemophilus influenzae ferric binding protein A. Biochem.J., 2010
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3OYP
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![BU of 3oyp by Molmil](/molmil-images/mine/3oyp) | HCV NS3/4A in complex with ligand 3 | Descriptor: | Non-structural protein 4A, Peptidomimetic inhibitor, Serine protease NS3, ... | Authors: | Hagel, M, Niu, D, St.Martin, T, Sheets, M.P, Qiao, L, Bernard, H, Karp, R.M, Zhu, Z, Labenski, M.T, Chaturvedi, P.C, Nacht, M, Westlin, W.F, Petter, R.C, Singh, J. | Deposit date: | 2010-09-23 | Release date: | 2010-12-01 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.76 Å) | Cite: | Selective irreversible inhibition of a protease by targeting a noncatalytic cysteine. Nat.Chem.Biol., 7, 2011
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7EQU
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![BU of 7equ by Molmil](/molmil-images/mine/7equ) | Crystal structure of the C-lobe of lactoferrin produced by limited proteolysis using pepsin at 2.74A resolution | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BICARBONATE ION, FE (III) ION, ... | Authors: | Maurya, A, Singh, J, Sharma, A, Sharma, P, Sharma, S, Singh, T.P. | Deposit date: | 2021-05-04 | Release date: | 2021-05-19 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.743 Å) | Cite: | Crystal structure of the C-lobe of lactoferrin produced by limited proteolysis using pepsin at 2.74A resolution To Be Published
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7EVQ
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![BU of 7evq by Molmil](/molmil-images/mine/7evq) | Crystal structure of C-terminal half of lactoferrin obtained by limited proteolysis using pepsin at 2.6 A resolution | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, BICARBONATE ION, ... | Authors: | Viswanathan, V, Singh, J, Sharma, P, Sharma, S, Singh, T.P. | Deposit date: | 2021-05-21 | Release date: | 2021-06-09 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of C-terminal half of lactoferrin obtained by limited proteolysis using pepsin at 2.6 A resolution To Be Published
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3BLA
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![BU of 3bla by Molmil](/molmil-images/mine/3bla) | Synthetic Gene Encoded DcpS bound to inhibitor DG153249 | Descriptor: | 5-[(1S)-1-(3-chlorophenyl)ethoxy]quinazoline-2,4-diamine, Scavenger mRNA-decapping enzyme DcpS | Authors: | Staker, B.L, Christensen, J, Stewart, L, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D) | Deposit date: | 2007-12-10 | Release date: | 2008-10-21 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | DcpS as a therapeutic target for spinal muscular atrophy. Acs Chem.Biol., 3, 2008
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3BL9
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![BU of 3bl9 by Molmil](/molmil-images/mine/3bl9) | Synthetic Gene Encoded DcpS bound to inhibitor DG157493 | Descriptor: | 5-{[1-(2,3-dichlorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine, Scavenger mRNA-decapping enzyme DcpS | Authors: | Staker, B.L, Christensen, J, Stewart, L, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D) | Deposit date: | 2007-12-10 | Release date: | 2008-10-21 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | DcpS as a therapeutic target for spinal muscular atrophy. Acs Chem.Biol., 3, 2008
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3BL7
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![BU of 3bl7 by Molmil](/molmil-images/mine/3bl7) | Synthetic Gene Encoded DcpS bound to inhibitor DG156844 | Descriptor: | 5-{[1-(2-fluorobenzyl)piperidin-4-yl]methoxy}quinazoline-2,4-diamine, Scavenger mRNA-decapping enzyme DcpS | Authors: | Staker, B.L, Christensen, J, Stewart, L, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D) | Deposit date: | 2007-12-10 | Release date: | 2008-10-21 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | DcpS as a therapeutic target for spinal muscular atrophy. Acs Chem.Biol., 3, 2008
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7Z0Y
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![BU of 7z0y by Molmil](/molmil-images/mine/7z0y) | THSC20.HVTR04 Fab bound to SARS-CoV-2 Receptor Binding Domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, Spike protein S1, ... | Authors: | Wibmer, C.K. | Deposit date: | 2022-02-23 | Release date: | 2022-04-13 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | A combination of potently neutralizing monoclonal antibodies isolated from an Indian convalescent donor protects against the SARS-CoV-2 Delta variant. Plos Pathog., 18, 2022
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7Z0X
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![BU of 7z0x by Molmil](/molmil-images/mine/7z0x) | THSC20.HVTR26 Fab bound to SARS-CoV-2 Receptor Binding Domain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Spike protein S1, ... | Authors: | Wibmer, C.K. | Deposit date: | 2022-02-23 | Release date: | 2022-04-13 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A combination of potently neutralizing monoclonal antibodies isolated from an Indian convalescent donor protects against the SARS-CoV-2 Delta variant. Plos Pathog., 18, 2022
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7WVL
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![BU of 7wvl by Molmil](/molmil-images/mine/7wvl) | |