7Z0Y

THSC20.HVTR04 Fab bound to SARS-CoV-2 Receptor Binding Domain

Summary for 7Z0Y

• Entry DOI: 10.2210/pdb7z0y/pdb
• Descriptor: THSC20.HVTR04 Fab heavy chain, THSC20.HVTR04 Fab light chain, Spike protein S1, ... (6 entities in total)
• Functional Keywords: neutralizing antibody, sars-cov-2, spike, rbd, antiviral protein, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 3
• Total formula weight: 71230.38

Authors

Wibmer, C.K. (deposition date: 2022-02-23, release date: 2022-04-13, Last modification date: 2022-05-11)

• Primary citation: Hingankar, N.,Deshpande, S.,Das, P.,Rizvi, Z.A.,Wibmer, C.K.,Mashilo, P.,Ansari, M.Y.,Burns, A.,Barman, S.,Zhao, F.,Mukherjee, S.,Torres, J.L.,Chattopadhyay, S.,Mehdi, F.,Sutar, J.,Rathore, D.K.,Pargai, K.,Singh, J.,Sonar, S.,Jakhar, K.,Dandotiya, J.,Bhattacharyya, S.,Mani, S.,Samal, S.,Singh, S.,Kshetrapal, P.,Thiruvengadam, R.,Batra, G.,Medigeshi, G.,Ward, A.B.,Bhatnagar, S.,Awasthi, A.,Sok, D.,Bhattacharya, J.; A combination of potently neutralizing monoclonal antibodies isolated from an Indian convalescent donor protects against the SARS-CoV-2 Delta variant.; Plos Pathog., 18:e1010465-e1010465, 2022; PubMed: 35482816; DOI: 10.1371/journal.ppat.1010465

Experimental method

X-RAY DIFFRACTION (2.95 Å)