6OEV
 
 | | Structure of human Patched1 in complex with native Sonic Hedgehog | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein patched homolog 1, ... | | Authors: | Qi, X, Li, X. | | Deposit date: | 2019-03-27 | | Release date: | 2019-04-17 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structures of human Patched and its complex with native palmitoylated sonic hedgehog.
Nature, 560, 2018
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6OEU
 | | Structure of human Patched1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Protein patched homolog 1 | | Authors: | Qi, X, Li, X, Wang, J. | | Deposit date: | 2019-03-27 | | Release date: | 2019-04-10 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structures of human Patched and its complex with native palmitoylated sonic hedgehog.
Nature, 560, 2018
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2XN6
 | | Crystal structure of thyroxine-binding globulin complexed with thyroxine-fluoresein | | Descriptor: | 1,2-ETHANEDIOL, 3',6'-DIHYDROXY-3-OXO-3H-SPIRO[2-BENZOFURAN-1,9'-XANTHENE]-6-CARBOXYLIC ACID, 3,5,3',5'-TETRAIODO-L-THYRONINE, ... | | Authors: | Qi, X, Yan, Y, Wei, Z, Zhou, A. | | Deposit date: | 2010-07-30 | | Release date: | 2011-02-16 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.29 Å) | | Cite: | Allosteric Modulation of Hormone Release from Thyroxine and Corticosteroid Binding-Globulins.
J.Biol.Chem., 286, 2011
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2XN7
 | | Crystal structure of thyroxine-binding globulin complexed with thyroxine-fluoresein (T405-CF) | | Descriptor: | 1,2-ETHANEDIOL, 3',6'-DIHYDROXY-3-OXO-3H-SPIRO[2-BENZOFURAN-1,9'-XANTHENE]-5-CARBOXYLIC ACID, 3,5,3',5'-TETRAIODO-L-THYRONINE, ... | | Authors: | Qi, X, Yan, Y, Wei, Z, Zhou, A. | | Deposit date: | 2010-07-30 | | Release date: | 2011-02-16 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.43 Å) | | Cite: | Allosteric Modulation of Hormone Release from Thyroxine and Corticosteroid Binding-Globulins.
J.Biol.Chem., 286, 2011
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2XN5
 | | Crystal structure of thyroxine-binding globulin complexed with Furosemide | | Descriptor: | 1,2-ETHANEDIOL, 5-(AMINOSULFONYL)-4-CHLORO-2-[(2-FURYLMETHYL)AMINO]BENZOIC ACID, CALCIUM ION, ... | | Authors: | Qi, X, Yan, Y, Wei, Z, Zhou, A. | | Deposit date: | 2010-07-30 | | Release date: | 2011-02-16 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Allosteric Modulation of Hormone Release from Thyroxine and Corticosteroid Binding-Globulins.
J.Biol.Chem., 286, 2011
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2XN3
 | | Crystal structure of thyroxine-binding globulin complexed with mefenamic acid | | Descriptor: | 2-[(2,3-DIMETHYLPHENYL)AMINO]BENZOIC ACID, THYROXINE-BINDING GLOBULIN | | Authors: | Qi, X, Yan, Y, Wei, Z, Zhou, A. | | Deposit date: | 2010-07-30 | | Release date: | 2011-02-16 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.09 Å) | | Cite: | Allosteric Modulation of Hormone Release from Thyroxine and Corticosteroid Binding-Globulins.
J.Biol.Chem., 286, 2011
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6XBM
 | | Structure of human SMO-Gi complex with 24(S),25-EC | | Descriptor: | 17-[3-(3,3-DIMETHYL-OXIRANYL)-1-METHYL-PROPYL]-10,13-DIMETHYL-2,3,4,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYC LOPENTA[A]PHENANTHREN-3-OL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Qi, X, Long, T, Li, X. | | Deposit date: | 2020-06-06 | | Release date: | 2020-09-30 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.14 Å) | | Cite: | Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling.
Nat.Chem.Biol., 16, 2020
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6XBL
 | | Structure of human SMO-Gi complex with SAG | | Descriptor: | 3-chloro-N-[trans-4-(methylamino)cyclohexyl]-N-{[3-(pyridin-4-yl)phenyl]methyl}-1-benzothiophene-2-carboxamide, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Qi, X, Li, X. | | Deposit date: | 2020-06-06 | | Release date: | 2020-09-30 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (3.96 Å) | | Cite: | Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling.
Nat.Chem.Biol., 16, 2020
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6XBK
 | | Structure of human SMO-G111C/I496C complex with Gi | | Descriptor: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Qi, X, Long, T, Li, X. | | Deposit date: | 2020-06-06 | | Release date: | 2020-09-30 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (3.24 Å) | | Cite: | Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling.
Nat.Chem.Biol., 16, 2020
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6XBJ
 | | Structure of human SMO-D384R complex with Gi | | Descriptor: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Qi, X, Long, T, Li, X. | | Deposit date: | 2020-06-06 | | Release date: | 2020-09-30 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.88 Å) | | Cite: | Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling.
Nat.Chem.Biol., 16, 2020
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6E1H
 | | Structure of 2:1 human Ptch1-Shh-N complex | | Descriptor: | CALCIUM ION, PALMITIC ACID, Protein patched homolog 1, ... | | Authors: | Qi, X, Li, X. | | Deposit date: | 2018-07-09 | | Release date: | 2018-08-29 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Two Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex.
Science, 362, 2018
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4X30
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6OT0
 | | Structure of human Smoothened-Gi complex | | Descriptor: | 17-[3-(3,3-DIMETHYL-OXIRANYL)-1-METHYL-PROPYL]-10,13-DIMETHYL-2,3,4,7,8,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYC LOPENTA[A]PHENANTHREN-3-OL, Fab heavy chain, Fab light chain, ... | | Authors: | Qi, X, Li, X. | | Deposit date: | 2019-05-02 | | Release date: | 2019-06-12 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (3.84 Å) | | Cite: | Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi.
Nature, 571, 2019
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3MWP
 | | Nucleoprotein structure of lassa fever virus | | Descriptor: | Nucleoprotein, ZINC ION | | Authors: | Qi, X, Lan, S, Wang, W, Schelde, L.M, Dong, H, Wallat, G, Liang, Y, Ly, H, Dong, C, Scottish Structural Proteomics Facility (SSPF) | | Deposit date: | 2010-05-06 | | Release date: | 2010-12-01 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.795 Å) | | Cite: | Cap binding and immune evasion revealed by Lassa nucleoprotein structure.
Nature, 468, 2010
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3MX5
 | | Lassa fever virus nucleoprotein complexed with UTP | | Descriptor: | Nucleoprotein, URIDINE 5'-TRIPHOSPHATE, ZINC ION | | Authors: | Qi, X, Lan, S, Wang, W, Schelde, L.M, Dong, H, Wallat, G, Liang, Y, Ly, H, Dong, C, Scottish Structural Proteomics Facility (SSPF) | | Deposit date: | 2010-05-06 | | Release date: | 2010-12-01 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.903 Å) | | Cite: | Cap binding and immune evasion revealed by Lassa nucleoprotein structure.
Nature, 468, 2010
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3MWT
 | | Crystal structure of Lassa fever virus nucleoprotein in complex with Mn2+ | | Descriptor: | MANGANESE (II) ION, Nucleoprotein, ZINC ION | | Authors: | Qi, X, Lan, S, Wang, W, Schelde, L.M, Dong, H, Wallat, G, Liang, Y, Ly, H, Dong, C, Scottish Structural Proteomics Facility (SSPF) | | Deposit date: | 2010-05-06 | | Release date: | 2010-12-01 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.982 Å) | | Cite: | Cap binding and immune evasion revealed by Lassa nucleoprotein structure.
Nature, 468, 2010
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3MX2
 | | Lassa fever virus Nucleoprotein complexed with dTTP | | Descriptor: | Nucleoprotein, THYMIDINE-5'-TRIPHOSPHATE, ZINC ION | | Authors: | Qi, X, Lan, S, Wang, W, Schelde, L.M, Dong, H, Wallat, G, Liang, Y, Ly, H, Dong, C, Scottish Structural Proteomics Facility (SSPF) | | Deposit date: | 2010-05-06 | | Release date: | 2010-12-01 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.983 Å) | | Cite: | Cap binding and immune evasion revealed by Lassa nucleoprotein structure.
Nature, 468, 2010
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8TZS
 | | Structure of human WLS | | Descriptor: | Protein wntless homolog | | Authors: | Qi, X, Hu, Q, Li, X. | | Deposit date: | 2023-08-27 | | Release date: | 2023-10-18 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3.84 Å) | | Cite: | Molecular basis of Wnt biogenesis, secretion, and Wnt7-specific signaling.
Cell, 186, 2023
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8TZP
 | | Structure of human Wnt7a bound to WLS and RECK | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, PALMITOLEIC ACID, Protein Wnt-7a, ... | | Authors: | Qi, X, Hu, Q, Li, X. | | Deposit date: | 2023-08-27 | | Release date: | 2023-10-18 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3.23 Å) | | Cite: | Molecular basis of Wnt biogenesis, secretion, and Wnt7-specific signaling.
Cell, 186, 2023
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8TZO
 | | Structure of human Wnt7a bound to WLS and CALR | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, Calreticulin, ... | | Authors: | Qi, X, Hu, Q, Li, X. | | Deposit date: | 2023-08-27 | | Release date: | 2023-10-18 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Molecular basis of Wnt biogenesis, secretion, and Wnt7-specific signaling.
Cell, 186, 2023
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8TZR
 | | Structure of human Wnt3a bound to WLS and CALR | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Calreticulin, PALMITOLEIC ACID, ... | | Authors: | Qi, X, Hu, Q, Li, X. | | Deposit date: | 2023-08-27 | | Release date: | 2023-10-18 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Molecular basis of Wnt biogenesis, secretion, and Wnt7-specific signaling.
Cell, 186, 2023
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8X6V
 | | Crystal structure of GlacPETase | | Descriptor: | GlacPETase | | Authors: | Qi, X, Zhou, N.Y. | | Deposit date: | 2023-11-22 | | Release date: | 2024-02-14 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.797 Å) | | Cite: | The unique salt bridge network in GlacPETase: a key to its stability.
Appl.Environ.Microbiol., 90, 2024
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5E6O
 | | Crystal structure of C. elegans LGG-2 bound to an AIM/LIR motif | | Descriptor: | Protein lgg-2, TRP-GLU-GLU-LEU | | Authors: | Qi, X, Ren, J.Q, Wu, F, Zhang, H, Feng, W. | | Deposit date: | 2015-10-10 | | Release date: | 2016-01-06 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy
Mol.Cell, 60, 2015
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5E6N
 | | Crystal structure of C. elegans LGG-2 | | Descriptor: | Protein lgg-2 | | Authors: | Qi, X, Ren, J.Q, Wu, F, Zhang, H, Feng, W. | | Deposit date: | 2015-10-10 | | Release date: | 2016-01-06 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.102 Å) | | Cite: | Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy
Mol.Cell, 60, 2015
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5HV1
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