6OKJ
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6MIS
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![BU of 6mis by Molmil](/molmil-images/mine/6mis) | Native ananain in complex with E-64 | Descriptor: | Ananain, N-[N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-BUTYL]-GUANIDINE | Authors: | Yongqing, T, Wilmann, P.G, Pike, R.N, Wijeyewickrema, L.C. | Deposit date: | 2018-09-20 | Release date: | 2018-10-03 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Determination of the crystal structure and substrate specificity of ananain. Biochimie, 166, 2019
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6U7D
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1AZX
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![BU of 1azx by Molmil](/molmil-images/mine/1azx) | ANTITHROMBIN/PENTASACCHARIDE COMPLEX | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,4-di-O-methyl-2,6-di-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-beta-D-glucopyranuronic acid-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-3-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2,3,6-tri-O-sulfo-alpha-D-glucopyranoside, ANTITHROMBIN | Authors: | Jin, L, Abrahams, J.P, Skinner, R, Petitou, M, Pike, R.N, Carrell, R.W. | Deposit date: | 1997-11-23 | Release date: | 1999-01-13 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The anticoagulant activation of antithrombin by heparin. Proc.Natl.Acad.Sci.USA, 94, 1997
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1D5S
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![BU of 1d5s by Molmil](/molmil-images/mine/1d5s) | CRYSTAL STRUCTURE OF CLEAVED ANTITRYPSIN POLYMER | Descriptor: | P1-ARG ANTITRYPSIN | Authors: | Dunstone, M.A, Dai, W, Whisstock, J.C, Rossjohn, J, Pike, R.N, Feil, S.C, Le Bonneic, B.F, Parker, M.W, Bottomley, S.P. | Deposit date: | 1999-10-11 | Release date: | 2000-04-02 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Cleaved antitrypsin polymers at atomic resolution. Protein Sci., 9, 2000
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1MTP
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![BU of 1mtp by Molmil](/molmil-images/mine/1mtp) | The X-ray crystal structure of a serpin from a thermophilic prokaryote | Descriptor: | Serine Proteinase Inhibitor (SERPIN), Chain A, Chain B | Authors: | Irving, J.A, Cabrita, L.D, Rossjohn, J, Pike, R.N, Bottomley, S.P, Whisstock, J.C. | Deposit date: | 2002-09-21 | Release date: | 2003-04-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | The 1.5 A crystal structure of a prokaryote serpin: controlling conformational change in a heated environment Structure, 11, 2003
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1YXA
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![BU of 1yxa by Molmil](/molmil-images/mine/1yxa) | Serpina3n, a murine orthologue of human antichymotrypsin | Descriptor: | serine (or cysteine) proteinase inhibitor, clade A, member 3N | Authors: | Horvath, A.J, Irving, J.A, Law, R.H, Rossjohn, J, Bottomley, S.P, Quinsey, N.S, Pike, R.N, Coughlin, P.B, Whisstock, J.C. | Deposit date: | 2005-02-20 | Release date: | 2005-09-06 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The murine orthologue of human antichymotrypsin: a structural paradigm for clade A3 serpins. J.Biol.Chem., 280, 2005
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4J1Y
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![BU of 4j1y by Molmil](/molmil-images/mine/4j1y) | The X-ray crystal structure of human complement protease C1s zymogen | Descriptor: | Complement C1s subcomponent | Authors: | Perry, A.J, Wijeyewickrema, L.C, Wilmann, P.G, Gunzburg, M.J, D'Andrea, L, Irving, J.A, Pang, S.S, Duncan, R.C, Wilce, J.A, Whisstock, J.C, Pike, R.N. | Deposit date: | 2013-02-03 | Release date: | 2013-04-24 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.6645 Å) | Cite: | A Molecular Switch Governs the Interaction between the Human Complement Protease C1s and Its Substrate, Complement C4. J.Biol.Chem., 288, 2013
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4KKD
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![BU of 4kkd by Molmil](/molmil-images/mine/4kkd) | The X-ray crystal structure of Mannose-binding lectin-associated serine proteinase-3 reveals the structural basis for enzyme inactivity associated with the 3MC syndrome | Descriptor: | IMIDAZOLE, Mannan-binding lectin serine protease 1 | Authors: | Yongqing, T, Wilmann, P.G, Reeve, S.B, Coetzer, T.H, Smith, A.I, Whisstock, J.C, Pike, R.N, Wijeyewickrema, L.C. | Deposit date: | 2013-05-05 | Release date: | 2013-07-03 | Last modified: | 2013-08-21 | Method: | X-RAY DIFFRACTION (2.5991 Å) | Cite: | The X-ray Crystal Structure of Mannose-binding Lectin-associated Serine Proteinase-3 Reveals the Structural Basis for Enzyme Inactivity Associated with the Carnevale, Mingarelli, Malpuech, and Michels (3MC) Syndrome. J.Biol.Chem., 288, 2013
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2QP2
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![BU of 2qp2 by Molmil](/molmil-images/mine/2qp2) | Structure of a MACPF/perforin-like protein | Descriptor: | CALCIUM ION, Unknown protein | Authors: | Rosado, C.J, Buckle, A.M, Law, R.H.P, Butcher, R.E, Kan, W.T, Bird, C.H, Ung, K, Browne, K.A, Baran, K, Bashtannyk-Puhalovich, T.A, Faux, N.G, Wong, W, Porter, C.J, Pike, R.N, Ellisdon, A.M, Pearce, M.C, Bottomley, S.P, Emsley, J, Smith, A.I, Rossjohn, J, Hartland, E.L, Voskoboinik, I, Trapani, J.A, Bird, P.I, Dunstone, M.A, Whisstock, J.C. | Deposit date: | 2007-07-22 | Release date: | 2007-09-04 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A common fold mediates vertebrate defense and bacterial attack Science, 317, 2007
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2DUT
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6OFR
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6OFS
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6OFT
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5UBM
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![BU of 5ubm by Molmil](/molmil-images/mine/5ubm) | Crystal structure of human C1s in complex with inhibitor gigastasin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C1s subcomponent, Gigastasin | Authors: | Pang, S.S, Whisstock, J.C. | Deposit date: | 2016-12-20 | Release date: | 2017-11-08 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The Structural Basis for Complement Inhibition by Gigastasin, a Protease Inhibitor from the Giant Amazon Leech. J. Immunol., 199, 2017
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3TI7
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3VP6
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![BU of 3vp6 by Molmil](/molmil-images/mine/3vp6) | Structural characterization of Glutamic Acid Decarboxylase; insights into the mechanism of autoinactivation | Descriptor: | 4-oxo-4H-pyran-2,6-dicarboxylic acid, GLYCEROL, Glutamate decarboxylase 1 | Authors: | Langendorf, C.G, Tuck, K.L, Key, T.L.G, Rosado, C.J, Wong, A.S.M, Fenalti, G, Buckle, A.M, Law, R.H.P, Whisstock, J.C. | Deposit date: | 2012-02-27 | Release date: | 2013-01-16 | Last modified: | 2013-08-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural characterization of the mechanism through which human glutamic acid decarboxylase auto-activates Biosci.Rep., 33, 2013
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3TI9
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![BU of 3ti9 by Molmil](/molmil-images/mine/3ti9) | Crystal structure of the basic protease BprB from the ovine footrot pathogen, Dichelobacter nodosus | Descriptor: | CALCIUM ION, CHLORIDE ION, GLYCEROL, ... | Authors: | Wong, W, Whisstock, J.C, Porter, C.J. | Deposit date: | 2011-08-20 | Release date: | 2011-10-19 | Last modified: | 2018-01-24 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | S1 Pocket of a Bacterially Derived Subtilisin-like Protease Underpins Effective Tissue Destruction. J.Biol.Chem., 286, 2011
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4FTF
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3LPC
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![BU of 3lpc by Molmil](/molmil-images/mine/3lpc) | Crystal structure of a subtilisin-like protease | Descriptor: | ACETATE ION, AprB2, CALCIUM ION, ... | Authors: | Porter, C.J, Wong, W, Whisstock, J.C, Rood, J.I, Kennan, R.M. | Deposit date: | 2010-02-05 | Release date: | 2010-12-08 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The Subtilisin-Like Protease AprV2 Is Required for Virulence and Uses a Novel Disulphide-Tethered Exosite to Bind Substrates Plos Pathog., 6, 2010
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3LPA
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![BU of 3lpa by Molmil](/molmil-images/mine/3lpa) | Crystal structure of a subtilisin-like protease | Descriptor: | Acidic extracellular subtilisin-like protease AprV2, CALCIUM ION | Authors: | Porter, C.J, Wong, W, Whisstock, J.C, Rood, J.I, Kennan, R.M. | Deposit date: | 2010-02-05 | Release date: | 2010-12-08 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The Subtilisin-Like Protease AprV2 Is Required for Virulence and Uses a Novel Disulphide-Tethered Exosite to Bind Substrates Plos Pathog., 6, 2010
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3LPD
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![BU of 3lpd by Molmil](/molmil-images/mine/3lpd) | Crystal structure of a subtilisin-like protease | Descriptor: | Acidic extracellular subtilisin-like protease AprV2, CALCIUM ION | Authors: | Porter, C.J, Wong, W, Whisstock, J.C, Rood, J.I, Kennan, R.M. | Deposit date: | 2010-02-05 | Release date: | 2010-12-08 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The Subtilisin-Like Protease AprV2 Is Required for Virulence and Uses a Novel Disulphide-Tethered Exosite to Bind Substrates Plos Pathog., 6, 2010
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4ZI6
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4ZLA
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4DUR
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![BU of 4dur by Molmil](/molmil-images/mine/4dur) | The X-ray Crystal Structure of Full-Length type II Human Plasminogen | Descriptor: | ACETATE ION, BICARBONATE ION, CHLORIDE ION, ... | Authors: | Law, R.H.P, Caradoc-Davies, T, Whisstock, J.C. | Deposit date: | 2012-02-22 | Release date: | 2012-03-28 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | The X-ray crystal structure of full-length human plasminogen Cell Rep, 1, 2012
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