7SJ3
| Structure of CDK4-Cyclin D3 bound to abemaciclib | Descriptor: | Cyclin-dependent kinase 4, G1/S-specific cyclin-D3, N-{5-[(4-ethylpiperazin-1-yl)methyl]pyridin-2-yl}-5-fluoro-4-[4-fluoro-2-methyl-1-(propan-2-yl)-1H-benzimidazol-6-yl]py rimidin-2-amine | Authors: | Hilgers, M.T, Pelletier, L.A. | Deposit date: | 2021-10-15 | Release date: | 2022-11-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Structure of CDK4-Cyclin D3 bound to abemaciclib To Be Published
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3COK
| Crystal structure of PLK4 kinase | Descriptor: | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SULFATE ION, Serine/threonine-protein kinase PLK4 | Authors: | Atwell, S, Burley, S.K, Houle, A, Leon, B, Pelletier, L.A, Sauder, J.M, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2008-03-28 | Release date: | 2008-04-15 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Crystal structure of PLK4 kinase. To be Published
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1AUI
| HUMAN CALCINEURIN HETERODIMER | Descriptor: | CALCIUM ION, FE (III) ION, SERINE/THREONINE PHOSPHATASE 2B, ... | Authors: | Kissinger, C.R, Parge, H.E, Knighton, D.R, Pelletier, L.A, Lewis, C.T, Tempczyk, A, Villafranca, J.E. | Deposit date: | 1997-08-27 | Release date: | 1997-12-03 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex. Nature, 378, 1995
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1U7T
| Crystal Structure of ABAD/HSD10 with a Bound Inhibitor | Descriptor: | 1-AZEPAN-1-YL-2-PHENYL-2-(4-THIOXO-1,4-DIHYDRO-PYRAZOLO[3,4-D]PYRIMIDIN-5-YL)ETHANONE ADDUCT, 3-hydroxyacyl-CoA dehydrogenase type II, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Kissinger, C.R, Rejto, P.A, Pelletier, L.A, Showalter, R.E, Villafranca, J.E. | Deposit date: | 2004-08-04 | Release date: | 2004-10-05 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of human ABAD/HSD10 with a bound inhibitor: implications for design of Alzheimer's disease therapeutics J.Mol.Biol., 342, 2004
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1CA0
| BOVINE CHYMOTRYPSIN COMPLEXED TO APPI | Descriptor: | BOVINE CHYMOTRYPSIN, PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR | Authors: | Scheidig, A.J, Kossiakoff, A.A. | Deposit date: | 1997-01-23 | Release date: | 1997-07-23 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities. Protein Sci., 6, 1997
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1CBW
| BOVINE CHYMOTRYPSIN COMPLEXED TO BPTI | Descriptor: | BOVINE CHYMOTRYPSIN, BPTI, SULFATE ION | Authors: | Hynes, T.R, Scheidig, A.J, Kossiakoff, A.A. | Deposit date: | 1996-12-22 | Release date: | 1997-07-23 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities. Protein Sci., 6, 1997
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1TAW
| BOVINE TRYPSIN COMPLEXED TO APPI | Descriptor: | CALCIUM ION, PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR, TRYPSIN | Authors: | Hynes, T.R, Kossiakoff, A.A. | Deposit date: | 1996-12-19 | Release date: | 1997-06-24 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities. Protein Sci., 6, 1997
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3DKF
| Structure of MET receptor tyrosine kinase in complex with inhibitor SGX-523 | Descriptor: | 6-{[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline, CHLORIDE ION, Hepatocyte growth factor receptor | Authors: | Hendle, J. | Deposit date: | 2008-06-24 | Release date: | 2009-07-07 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo. Mol.Cancer Ther., 8, 2009
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3DKG
| Structure of Mutant(Y1248L) MET receptor tyrosine kinase in complex with inhibitor SGX-523 | Descriptor: | 6-{[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline, CHLORIDE ION, Hepatocyte growth factor receptor | Authors: | Hendle, J. | Deposit date: | 2008-06-24 | Release date: | 2009-07-07 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo. Mol.Cancer Ther., 8, 2009
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3DKC
| Structure of MET receptor tyrosine kinase in complex with ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, Hepatocyte growth factor receptor, ... | Authors: | Hendle, J. | Deposit date: | 2008-06-24 | Release date: | 2009-07-07 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo. Mol.Cancer Ther., 8, 2009
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3LL8
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2P6B
| Crystal Structure of Human Calcineurin in Complex with PVIVIT Peptide | Descriptor: | CALCIUM ION, Calcineurin subunit B isoform 1, Calmodulin-dependent calcineurin A subunit alpha isoform, ... | Authors: | Li, H, Zhang, L, Rao, A, Harrison, S.C, Hogan, P.G. | Deposit date: | 2007-03-16 | Release date: | 2007-06-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of calcineurin in complex with PVIVIT peptide: Portrait of a low-affinity signalling interaction J.Mol.Biol., 369, 2007
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1T8N
| CRYSTAL STRUCTURE OF THE P1 THR BPTI MUTANT- BOVINE CHYMOTRYPSIN COMPLEX | Descriptor: | Chymotrypsin A, Pancreatic trypsin inhibitor, SULFATE ION | Authors: | Czapinska, H, Helland, R, Otlewski, J, Smalas, A.O. | Deposit date: | 2004-05-13 | Release date: | 2005-03-08 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Crystal structures of five bovine chymotrypsin complexes with P1 BPTI variants. J.Mol.Biol., 344, 2004
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1T8L
| CRYSTAL STRUCTURE OF THE P1 MET BPTI MUTANT- BOVINE CHYMOTRYPSIN COMPLEX | Descriptor: | Chymotrypsin A, Pancreatic trypsin inhibitor, SULFATE ION | Authors: | Czapinska, H, Helland, R, Otlewski, J, Smalas, A.O. | Deposit date: | 2004-05-13 | Release date: | 2005-03-08 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Crystal structures of five bovine chymotrypsin complexes with P1 BPTI variants. J.Mol.Biol., 344, 2004
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1T8O
| CRYSTAL STRUCTURE OF THE P1 TRP BPTI MUTANT- BOVINE CHYMOTRYPSIN COMPLEX | Descriptor: | Chymotrypsin A, Pancreatic trypsin inhibitor, SULFATE ION | Authors: | Czapinska, H, Helland, R, Otlewski, J, Smalas, A.O. | Deposit date: | 2004-05-13 | Release date: | 2005-03-08 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structures of five bovine chymotrypsin complexes with P1 BPTI variants. J.Mol.Biol., 344, 2004
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1T8M
| CRYSTAL STRUCTURE OF THE P1 HIS BPTI MUTANT- BOVINE CHYMOTRYPSIN COMPLEX | Descriptor: | Chymotrypsin A, Pancreatic trypsin inhibitor, SULFATE ION | Authors: | Czapinska, H, Helland, R, Otlewski, J, Smalas, A.O. | Deposit date: | 2004-05-13 | Release date: | 2005-03-08 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structures of five bovine chymotrypsin complexes with P1 BPTI variants. J.Mol.Biol., 344, 2004
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1T7C
| CRYSTAL STRUCTURE OF THE P1 GLU BPTI MUTANT- BOVINE CHYMOTRYPSIN COMPLEX | Descriptor: | Chymotrypsin A, Pancreatic trypsin inhibitor, SULFATE ION | Authors: | Czapinska, H, Helland, R, Otlewski, J, Smalas, A.O. | Deposit date: | 2004-05-09 | Release date: | 2005-03-08 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Crystal structures of five bovine chymotrypsin complexes with P1 BPTI variants. J.Mol.Biol., 344, 2004
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