Crystal Structure of ABAD/HSD10 with a Bound Inhibitor

Summary for 1U7T
Descriptor3-hydroxyacyl-CoA dehydrogenase type II, 1-AZEPAN-1-YL-2-PHENYL-2-(4-THIOXO-1,4-DIHYDRO-PYRAZOLO[3,4-D]PYRIMIDIN-5-YL)ETHANONE ADDUCT, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... (4 entities in total)
Functional Keywordsprotein-inhibitor complex, rossmann fold, oxidoreductase
Biological sourceHomo sapiens (human)
Cellular locationMitochondrion : Q99714
Total number of polymer chains4
Total formula weight111748.30
Kissinger, C.R.,Rejto, P.A.,Pelletier, L.A.,Showalter, R.E.,Villafranca, J.E. (deposition date: 2004-08-04, release date: 2004-10-05, Last modification date: 2018-04-04)
Primary citationAbreo, M.A.,Agree, C.S.,Aust, R.M.,Kissinger, C.R.,Li, B.,Margosiak, S.,Meng, J.J.,Pelletier, L.A.,Rejto, P.A.,Showalter, R.E.,Tempczyk-Russell, A.,Thomson, J.A.,Vanderpool, D.,Villafranca, J.E.
Crystal structure of human ABAD/HSD10 with a bound inhibitor: implications for design of Alzheimer's disease therapeutics
J.Mol.Biol., 342:943-952, 2004
PubMed: 15342248
DOI: 110.1016/j.jmb.2004.07.071
PDB entries with the same primary citation
Experimental method
Structure validation
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PDB entries from 2021-06-16