1U7T
Crystal Structure of ABAD/HSD10 with a Bound Inhibitor
Summary for 1U7T
Entry DOI | 10.2210/pdb1u7t/pdb |
Descriptor | 3-hydroxyacyl-CoA dehydrogenase type II, 1-AZEPAN-1-YL-2-PHENYL-2-(4-THIOXO-1,4-DIHYDRO-PYRAZOLO[3,4-D]PYRIMIDIN-5-YL)ETHANONE ADDUCT, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... (4 entities in total) |
Functional Keywords | protein-inhibitor complex, rossmann fold, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Mitochondrion : Q99714 |
Total number of polymer chains | 4 |
Total formula weight | 111748.30 |
Authors | Kissinger, C.R.,Rejto, P.A.,Pelletier, L.A.,Showalter, R.E.,Villafranca, J.E. (deposition date: 2004-08-04, release date: 2004-10-05, Last modification date: 2024-04-03) |
Primary citation | Kissinger, C.R.,Rejto, P.A.,Pelletier, L.A.,Thomson, J.A.,Showalter, R.E.,Abreo, M.A.,Agree, C.S.,Margosiak, S.,Meng, J.J.,Aust, R.M.,Vanderpool, D.,Li, B.,Tempczyk-Russell, A.,Villafranca, J.E. Crystal structure of human ABAD/HSD10 with a bound inhibitor: implications for design of Alzheimer's disease therapeutics J.Mol.Biol., 342:943-952, 2004 Cited by PubMed: 15342248DOI: 10.1016/j.jmb.2004.07.071 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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