1U7T
Crystal Structure of ABAD/HSD10 with a Bound Inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | 3-hydroxyacyl-CoA dehydrogenase type II | polymer | 261 | 27001.1 | 4 | UniProt (Q99714) Pfam (PF00106) | Homo sapiens (human) | Type II HADH, Endoplasmic reticulum-associated amyloid beta-peptide binding protein, Short-chain type dehydrogenase/reductase XH98G2, AMYLOID BETA-PEPTIDE-BINDING ALCOHOL DEHYDROGENASE, ABAD |
| 2 | E, G, H (A, C, D) | 1-AZEPAN-1-YL-2-PHENYL-2-(4-THIOXO-1,4-DIHYDRO-PYRAZOLO[3,4-D]PYRIMIDIN-5-YL)ETHANONE ADDUCT | non-polymer | 1026.9 | 3 | Chemie (TDT) | |||
| 3 | F (B) | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 1 | Chemie (NAD) | |||
| 4 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 282 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 261 (UniProt: Q99714)
| PDB | External Database | Details |
|---|---|---|
| Arg 214 | Cys 214 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 108004.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 3744.0 | |
| All* | Total formula weight | 111748.3 |
