1SYX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1syx by Molmil](/molmil-images/mine/1syx) | The crystal structure of a binary U5 snRNP complex | Descriptor: | CD2 antigen cytoplasmic tail-binding protein 2, Spliceosomal U5 snRNP-specific 15 kDa protein | Authors: | Nielsen, T.K, Liu, S, Luhrmann, R, Ficner, R. | Deposit date: | 2004-04-02 | Release date: | 2005-10-18 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.345 Å) | Cite: | Structural basis for the bifunctionality of the U5 snRNP 52K protein (CD2BP2). J.Mol.Biol., 369, 2007
|
|
1E7K
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1e7k by Molmil](/molmil-images/mine/1e7k) | Crystal structure of the spliceosomal 15.5kD protein bound to a U4 snRNA fragment | Descriptor: | 15.5 KD RNA BINDING PROTEIN, RNA (5'-R(*GP*CP*CP*AP*AP*UP*GP*AP*GP*GP*UP*UP*UP* AP*UP*CP*CP*GP*AP*GP*G*C(-3') | Authors: | Vidovic, I, Nottrott, S, Harthmuth, K, Luhrmann, R, Ficner, R. | Deposit date: | 2000-08-29 | Release date: | 2001-02-19 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal Structure of the Spliceosomal 15.5Kd Protein Bound to a U4 Snrna Fragment Mol.Cell, 6, 2000
|
|
3JCR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3jcr by Molmil](/molmil-images/mine/3jcr) | 3D structure determination of the human*U4/U6.U5* tri-snRNP complex | Descriptor: | LSm2, LSm3, LSm4, ... | Authors: | Agafonov, D.E, Kastner, B, Dybkov, O, Hofele, R.V, Liu, W.T, Urlaub, H, Luhrmann, R, Stark, H. | Deposit date: | 2016-01-21 | Release date: | 2016-03-09 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (7 Å) | Cite: | Molecular architecture of the human U4/U6.U5 tri-snRNP. Science, 351, 2016
|
|
5IFE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ife by Molmil](/molmil-images/mine/5ife) | Crystal structure of the human SF3b core complex | Descriptor: | PHD finger-like domain-containing protein 5A, POTASSIUM ION, Splicing factor 3B subunit 1, ... | Authors: | Cretu, C, Dybkov, O, De Laurentiis, E, Will, C.L, Luhrmann, R, Pena, V. | Deposit date: | 2016-02-25 | Release date: | 2016-10-26 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations. Mol.Cell, 64, 2016
|
|
4PJ3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4pj3 by Molmil](/molmil-images/mine/4pj3) | Structural insight into the function and evolution of the spliceosomal helicase Aquarius, Structure of Aquarius in complex with AMPPNP | Descriptor: | Intron-binding protein aquarius, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | Authors: | De, I, Bessonov, S, Hofele, R, dos Santos, K.F, Will, C.L, Urlaub, H, Luhrmann, R, Pena, V. | Deposit date: | 2014-05-11 | Release date: | 2015-01-21 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The RNA helicase Aquarius exhibits structural adaptations mediating its recruitment to spliceosomes. Nat.Struct.Mol.Biol., 22, 2015
|
|
2MKC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2mkc by Molmil](/molmil-images/mine/2mkc) | Cooperative Structure of the Heterotrimeric pre-mRNA Retention and Splicing Complex | Descriptor: | Pre-mRNA leakage protein 1, Pre-mRNA-splicing factor CWC26, U2 snRNP component IST3 | Authors: | Wysoczanski, P, Schneider, C, Xiang, S, Munari, F, Trowitzsch, S, Wahl, M.C, Luhrmann, R, Becker, S, Zweckstetter, M. | Deposit date: | 2014-02-04 | Release date: | 2014-09-03 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Cooperative structure of the heterotrimeric pre-mRNA retention and splicing complex. Nat.Struct.Mol.Biol., 21, 2014
|
|
3SIU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3siu by Molmil](/molmil-images/mine/3siu) | Structure of a hPrp31-15.5K-U4atac 5' stem loop complex, monomeric form | Descriptor: | NHP2-like protein 1, SULFATE ION, U4/U6 small nuclear ribonucleoprotein Prp31, ... | Authors: | Liu, S, Ghalei, H, Luhrmann, R, Wahl, M.C. | Deposit date: | 2011-06-20 | Release date: | 2011-08-10 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.626 Å) | Cite: | Structural basis for the dual U4 and U4atac snRNA-binding specificity of spliceosomal protein hPrp31. Rna, 17, 2011
|
|
3SIV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3siv by Molmil](/molmil-images/mine/3siv) | Structure of a hPrp31-15.5K-U4atac 5' stem loop complex, dimeric form | Descriptor: | NHP2-like protein 1, U4/U6 small nuclear ribonucleoprotein Prp31, U4atac snRNA | Authors: | Liu, S, Ghalei, H, Luhrmann, R, Wahl, M.C. | Deposit date: | 2011-06-20 | Release date: | 2011-08-10 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.304 Å) | Cite: | Structural basis for the dual U4 and U4atac snRNA-binding specificity of spliceosomal protein hPrp31. Rna, 17, 2011
|
|
5D0U
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5d0u by Molmil](/molmil-images/mine/5d0u) | |
3ELS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3els by Molmil](/molmil-images/mine/3els) | Crystal Structure of Yeast Pml1p, Residues 51-204 | Descriptor: | CHLORIDE ION, GLYCEROL, MAGNESIUM ION, ... | Authors: | Trowitzsch, S, Weber, G, Luehrmann, R, Wahl, M.C. | Deposit date: | 2008-09-23 | Release date: | 2009-02-10 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of the Pml1p subunit of the yeast precursor mRNA retention and splicing complex. J.Mol.Biol., 385, 2009
|
|
3ELV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3elv by Molmil](/molmil-images/mine/3elv) | Crystal Structure of Full-Length Yeast Pml1p | Descriptor: | Pre-mRNA leakage protein 1, SULFATE ION | Authors: | Trowitzsch, S, Weber, G, L hrmann, R, Wahl, M.C. | Deposit date: | 2008-09-23 | Release date: | 2009-02-10 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of the Pml1p subunit of the yeast precursor mRNA retention and splicing complex. J.Mol.Biol., 385, 2009
|
|
1QGV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1qgv by Molmil](/molmil-images/mine/1qgv) | HUMAN SPLICEOSOMAL PROTEIN U5-15KD | Descriptor: | SPLICEOSOMAL PROTEIN U5-15KD | Authors: | Reuter, K, Nottrott, S, Fabrizio, P, Luehrmann, R, Ficner, R. | Deposit date: | 1999-05-06 | Release date: | 1999-12-12 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Identification, characterization and crystal structure analysis of the human spliceosomal U5 snRNP-specific 15 kD protein. J.Mol.Biol., 294, 1999
|
|
4ILJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ilj by Molmil](/molmil-images/mine/4ilj) | |
4ILI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ili by Molmil](/molmil-images/mine/4ili) | |
4ILG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ilg by Molmil](/molmil-images/mine/4ilg) | Crystal structure of Aar2p in complex with the Prp8p RNaseH and Jab1/MPN domains | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, A1 cistron-splicing factor AAR2, Pre-mRNA-splicing factor 8 | Authors: | Weber, G, Heroven, A.C, Santos, K.F, Wahl, M.C. | Deposit date: | 2012-12-31 | Release date: | 2013-03-13 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis for dual roles of Aar2p in U5 snRNP assembly. Genes Dev., 27, 2013
|
|
2OZB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2ozb by Molmil](/molmil-images/mine/2ozb) | Structure of a human Prp31-15.5K-U4 snRNA complex | Descriptor: | CALCIUM ION, RNA comprising the 5' Stem-Loop RNA of U4snRNA, U4/U6 small nuclear ribonucleoprotein Prp31, ... | Authors: | Liu, S, Luehrmann, R, Wahl, M.C. | Deposit date: | 2007-02-26 | Release date: | 2007-03-20 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Binding of the human Prp31 Nop domain to a composite RNA-protein platform in U4 snRNP. Science, 316, 2007
|
|
3PGW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3pgw by Molmil](/molmil-images/mine/3pgw) | Crystal structure of human U1 snRNP | Descriptor: | DNA 5'-D(*AP*GP*GP*TP*AP*AP*GP*TP*A)-3', Sm B, Sm G, ... | Authors: | Weber, G, Trowitzsch, S, Kastner, B, Luehrmann, R, Wahl, M.C. | Deposit date: | 2010-11-02 | Release date: | 2010-12-29 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (4.4 Å) | Cite: | Functional organization of the Sm core in the crystal structure of human U1 snRNP. Embo J., 29, 2010
|
|
6Y53
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6y53 by Molmil](/molmil-images/mine/6y53) | human 17S U2 snRNP low resolution part | Descriptor: | HIV Tat-specific factor 1, Probable ATP-dependent RNA helicase DDX46, Small nuclear ribonucleoprotein E, ... | Authors: | Zhang, Z, Will, C.L, Bertram, K, Luehrmann, R, Stark, H. | Deposit date: | 2020-02-24 | Release date: | 2020-06-17 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (7.1 Å) | Cite: | Molecular architecture of the human 17S U2 snRNP. Nature, 583, 2020
|
|
6Y5Q
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6y5q by Molmil](/molmil-images/mine/6y5q) | human 17S U2 snRNP | Descriptor: | HIV Tat-specific factor 1, PHD finger-like domain-containing protein 5A, Probable ATP-dependent RNA helicase DDX46, ... | Authors: | Zhang, Z, Will, C.L, Bertram, K, Luehrmann, R, Stark, H. | Deposit date: | 2020-02-25 | Release date: | 2020-06-17 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (7.1 Å) | Cite: | Molecular architecture of the human 17S U2 snRNP. Nature, 583, 2020
|
|
6Y50
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6y50 by Molmil](/molmil-images/mine/6y50) | 5'domain of human 17S U2 snRNP | Descriptor: | HIV Tat-specific factor 1, PHD finger-like domain-containing protein 5A, Probable ATP-dependent RNA helicase DDX46, ... | Authors: | Zhang, Z, Will, C.L, Bertram, K, Luehrmann, R, Stark, H. | Deposit date: | 2020-02-24 | Release date: | 2020-07-01 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Molecular architecture of the human 17S U2 snRNP. Nature, 583, 2020
|
|
6SLO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6slo by Molmil](/molmil-images/mine/6slo) | Crystal structure of PUF60 UHM domain in complex with 7,8 dimethoxyperphenazine | Descriptor: | 2-[4-[3-(8-chloranyl-2,3-dimethoxy-phenothiazin-10-yl)propyl]piperazin-1-yl]ethanol, MAGNESIUM ION, Thioredoxin,Poly(U)-binding-splicing factor PUF60 | Authors: | Jagtap, P.K.A, Kubelka, T, Bach, T, Sattler, M. | Deposit date: | 2019-08-20 | Release date: | 2020-09-09 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly. Nat Commun, 11, 2020
|
|
5DCA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5dca by Molmil](/molmil-images/mine/5dca) | Crystal structure of yeast full length Brr2 in complex with Prp8 Jab1 domain | Descriptor: | Pre-mRNA-splicing factor 8, Pre-mRNA-splicing helicase BRR2 | Authors: | Absmeier, E, Wollenhaupt, J, Santos, K.F, Wahl, M.C. | Deposit date: | 2015-08-23 | Release date: | 2015-12-16 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation. Genes Dev., 29, 2015
|
|
7OQB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7oqb by Molmil](/molmil-images/mine/7oqb) | The U2 part of Saccharomyces cerevisiae spliceosomal pre-A complex (delta BS-A ACT1) | Descriptor: | ACT1 pre-mRNA (delta-BS-A), Cold sensitive U2 snRNA suppressor 1, Pre-mRNA-processing ATP-dependent RNA helicase PRP5, ... | Authors: | Zhang, Z, Rigo, N, Dybkov, O, Fourmann, J, Will, C.L, Kumar, V, Urlaub, H, Stark, H, Luehrmann, R. | Deposit date: | 2021-06-03 | Release date: | 2021-08-11 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (9 Å) | Cite: | Structural insights into how Prp5 proofreads the pre-mRNA branch site. Nature, 596, 2021
|
|
7OQE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7oqe by Molmil](/molmil-images/mine/7oqe) | Saccharomyces cerevisiae spliceosomal pre-A complex (delta BS-A ACT1) | Descriptor: | 56 kDa U1 small nuclear ribonucleoprotein component, ACT1 pre-mRNA (delta BS-A), Cold sensitive U2 snRNA suppressor 1, ... | Authors: | Zhang, Z, Rigo, N, Dybkov, O, Fourmann, J, Will, C.L, Kumar, V, Urlaub, H, Stark, H, Luehrmann, R. | Deposit date: | 2021-06-03 | Release date: | 2021-08-11 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (5.9 Å) | Cite: | Structural insights into how Prp5 proofreads the pre-mRNA branch site. Nature, 596, 2021
|
|
7OQC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7oqc by Molmil](/molmil-images/mine/7oqc) | The U1 part of Saccharomyces cerevisiae spliceosomal pre-A complex (delta BS-A ACT1) | Descriptor: | 56 kDa U1 small nuclear ribonucleoprotein component, ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A),ACT1 pre-mRNA (delta BS-A), Pre-mRNA-processing factor 39, ... | Authors: | Zhang, Z, Rigo, N, Dybkov, O, Fourmann, J, Will, C.L, Kumar, V, Urlaub, H, Stark, H, Luehrmann, R. | Deposit date: | 2021-06-03 | Release date: | 2021-08-11 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural insights into how Prp5 proofreads the pre-mRNA branch site. Nature, 596, 2021
|
|