1JQK
 
 | | Crystal structure of carbon monoxide dehydrogenase from Rhodospirillum rubrum | | Descriptor: | FE (II) ION, FE(3)-NI(1)-S(4) CLUSTER, IRON/SULFUR CLUSTER, ... | | Authors: | Drennan, C.L, Heo, J, Sintchak, M.D, Schreiter, E, Ludden, P.W. | | Deposit date: | 2001-08-07 | | Release date: | 2001-10-17 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Life on carbon monoxide: X-ray structure of Rhodospirillum rubrum Ni-Fe-S carbon monoxide dehydrogenase.
Proc.Natl.Acad.Sci.USA, 98, 2001
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1BMT
 | | HOW A PROTEIN BINDS B12: A 3.O ANGSTROM X-RAY STRUCTURE OF THE B12-BINDING DOMAINS OF METHIONINE SYNTHASE | | Descriptor: | CO-METHYLCOBALAMIN, METHIONINE SYNTHASE | | Authors: | Drennan, C.L, Huang, S, Drummond, J.T, Matthews, R.G, Ludwig, M.L. | | Deposit date: | 1994-09-02 | | Release date: | 1995-06-03 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | How a protein binds B12: A 3.0 A X-ray structure of B12-binding domains of methionine synthase.
Science, 266, 1994
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1D03
 | | REFINED STRUCTURES OF OXIDIZED FLAVODOXIN FROM ANACYSTIS NIDULANS | | Descriptor: | FLAVIN MONONUCLEOTIDE, FLAVODOXIN | | Authors: | Drennan, C.L, Pattridge, K.A, Weber, C.H, Metzger, A.L, Hoover, D.M, Ludwig, M.L. | | Deposit date: | 1999-09-08 | | Release date: | 1999-12-29 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Refined structures of oxidized flavodoxin from Anacystis nidulans.
J.Mol.Biol., 294, 1999
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1CZU
 | | REFINED STRUCTURES OF OXIDIZED FLAVODOXIN FROM ANACYSTIS NIDULANS | | Descriptor: | FLAVIN MONONUCLEOTIDE, FLAVODOXIN | | Authors: | Drennan, C.L, Pattridge, K.A, Weber, C.H, Metzger, A.L, Hoover, D.M, Ludwig, M.L. | | Deposit date: | 1999-09-07 | | Release date: | 1999-12-29 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Refined structures of oxidized flavodoxin from Anacystis nidulans.
J.Mol.Biol., 294, 1999
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4XJK
 | | Crystal structure of Mn(II) Ca(II) Na(I) bound calprotectin | | Descriptor: | CALCIUM ION, MANGANESE (II) ION, Protein S100-A8, ... | | Authors: | Drennan, C.L, Bowman, S.E.J. | | Deposit date: | 2015-01-08 | | Release date: | 2015-04-15 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.76 Å) | | Cite: | Manganese Binding Properties of Human Calprotectin under Conditions of High and Low Calcium: X-ray Crystallographic and Advanced Electron Paramagnetic Resonance Spectroscopic Analysis.
J.Am.Chem.Soc., 137, 2015
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4J1X
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4J1W
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3SCG
 | | Fe(II)-HppE with R-HPP | | Descriptor: | Epoxidase, FE (II) ION, [(2R)-2-hydroxypropyl]phosphonic acid | | Authors: | Drennan, C.L. | | Deposit date: | 2011-06-07 | | Release date: | 2011-07-06 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structural basis of regiospecificity of a mononuclear iron enzyme in antibiotic fosfomycin biosynthesis.
J.Am.Chem.Soc., 133, 2011
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3SCH
 | | Co(II)-HppE with R-HPP | | Descriptor: | COBALT (II) ION, Epoxidase, [(2R)-2-hydroxypropyl]phosphonic acid | | Authors: | Drennan, C.L. | | Deposit date: | 2011-06-07 | | Release date: | 2011-07-06 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural basis of regiospecificity of a mononuclear iron enzyme in antibiotic fosfomycin biosynthesis.
J.Am.Chem.Soc., 133, 2011
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4M7T
 | | Crystal structure of BtrN in complex with AdoMet and 2-DOIA | | Descriptor: | (1R,2S,3S,4R,5S)-5-aminocyclohexane-1,2,3,4-tetrol, BtrN, GLYCEROL, ... | | Authors: | Drennan, C.L, Goldman, P.J. | | Deposit date: | 2013-08-12 | | Release date: | 2013-10-02 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.56 Å) | | Cite: | X-ray analysis of butirosin biosynthetic enzyme BtrN redefines structural motifs for AdoMet radical chemistry.
Proc.Natl.Acad.Sci.USA, 110, 2013
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3SCF
 | | Fe(II)-HppE with S-HPP and NO | | Descriptor: | (S)-2-HYDROXYPROPYLPHOSPHONIC ACID, Epoxidase, FE (II) ION, ... | | Authors: | Drennan, C.L. | | Deposit date: | 2011-06-07 | | Release date: | 2011-07-06 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Structural basis of regiospecificity of a mononuclear iron enzyme in antibiotic fosfomycin biosynthesis.
J.Am.Chem.Soc., 133, 2011
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8V9I
 | | 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) from Deinococcus radiodurans with D-phenylalanine-derived triazole acetylphosphonate (D-PheTrAP) bound | | Descriptor: | 1-deoxy-D-xylulose-5-phosphate synthase, 2-HYDROXY BUTANE-1,4-DIOL, 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-{(1S)-1-[(S)-(2-{1-[(1R)-1-carboxy-2-phenylethyl]-1H-1,2,3-triazol-4-yl}ethoxy)(hydroxy)phosphoryl]-1-hydroxyethyl}-5-(2-{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium, ... | | Authors: | Chen, P.Y.-T, Drennan, C.L. | | Deposit date: | 2023-12-08 | | Release date: | 2024-04-24 | | Method: | X-RAY DIFFRACTION (1.981 Å) | | Cite: | Potent Inhibition of E. coli DXP Synthase by a gem -Diaryl Bisubstrate Analog.
Acs Infect Dis., 10, 2024
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5T6O
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3U33
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3UBY
 | | Crystal structure of human alklyadenine DNA glycosylase in a lower and higher-affinity complex with DNA | | Descriptor: | DNA (5'-D(*GP*AP*CP*AP*TP*GP*(EDC)P*TP*TP*GP*CP*CP*T)-3'), DNA-3-methyladenine glycosylase | | Authors: | Setser, J.W, Lingaraju, G.M, Davis, C.A, Samson, L.D, Drennan, C.L. | | Deposit date: | 2011-10-25 | | Release date: | 2011-12-28 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Searching for DNA lesions: structural evidence for lower- and higher-affinity DNA binding conformations of human alkyladenine DNA glycosylase.
Biochemistry, 51, 2012
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6EFN
 | | Structure of a RiPP maturase, SkfB | | Descriptor: | FE2/S2 (INORGANIC) CLUSTER, IRON/SULFUR CLUSTER, MAGNESIUM ION, ... | | Authors: | Grell, T.A.J, Drennan, C.L. | | Deposit date: | 2018-08-16 | | Release date: | 2018-10-24 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.291 Å) | | Cite: | Structure of a RiPP maturase, SkfB
J.Biol.Chem., 2018
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6DJT
 | | Structure of TYW1 with a lysine-pyruvate adduct bound | | Descriptor: | DI(HYDROXYETHYL)ETHER, FE2/S3 CLUSTER, GLYCEROL, ... | | Authors: | Grell, T.A.J, Drennan, C.L. | | Deposit date: | 2018-05-26 | | Release date: | 2018-06-13 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.64 Å) | | Cite: | Biochemical and Structural Characterization of a Schiff Base in the Radical-Mediated Biosynthesis of 4-Demethylwyosine by TYW1.
J. Am. Chem. Soc., 140, 2018
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1MJG
 | | CRYSTAL STRUCTURE OF BIFUNCTIONAL CARBON MONOXIDE DEHYDROGENASE/ACETYL-COA SYNTHASE(CODH/ACS) FROM MOORELLA THERMOACETICA (F. CLOSTRIDIUM THERMOACETICUM) | | Descriptor: | ACETATE ION, CARBON MONOXIDE DEHYDROGENASE BETA SUBUNIT, COPPER (I) ION, ... | | Authors: | Doukov, T.I, Iverson, T.M, Seravalli, J, Ragsdale, S.W, Drennan, C.L. | | Deposit date: | 2002-08-27 | | Release date: | 2003-01-28 | | Last modified: | 2019-11-20 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | A Ni-Fe-Cu center in a bifunctional carbon monoxide dehydrogenase/acetyl-CoA
synthase
Science, 298, 2002
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8DPB
 | | MeaB in complex with the cobalamin-binding domain of its target mutase with GMPPCP bound | | Descriptor: | GLYCEROL, MAGNESIUM ION, Methylmalonyl-CoA mutase accessory protein, ... | | Authors: | Vaccaro, F.A, Born, D.A, Drennan, C.L. | | Deposit date: | 2022-07-15 | | Release date: | 2023-03-01 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.72 Å) | | Cite: | Structure of metallochaperone in complex with the cobalamin-binding domain of its target mutase provides insight into cofactor delivery.
Proc.Natl.Acad.Sci.USA, 120, 2023
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4IXN
 | | Crystal Structure of Zn(II)-bound E37A,C66A,C67A triple mutant YjiA GTPase | | Descriptor: | SULFATE ION, Uncharacterized GTP-binding protein YjiA, ZINC ION | | Authors: | Jost, M, Drennan, C.L. | | Deposit date: | 2013-01-26 | | Release date: | 2013-02-27 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Metal binding properties of Escherichia coli YjiA, a member of the metal homeostasis-associated COG0523 family of GTPases.
Biochemistry, 52, 2013
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5FAV
 | | E491Q mutant of choline TMA-lyase | | Descriptor: | Choline trimethylamine-lyase, MALONATE ION, SODIUM ION | | Authors: | Funk, M.A, Drennan, C.L. | | Deposit date: | 2015-12-12 | | Release date: | 2016-09-28 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Molecular Basis of C-N Bond Cleavage by the Glycyl Radical Enzyme Choline Trimethylamine-Lyase.
Cell Chem Biol, 23, 2016
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5FAY
 | | Y208F mutant of choline TMA-lyase | | Descriptor: | CHOLINE ION, Choline trimethylamine-lyase, MALONATE ION, ... | | Authors: | Funk, M.A, Drennan, C.L. | | Deposit date: | 2015-12-12 | | Release date: | 2016-09-28 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.901 Å) | | Cite: | Molecular Basis of C-N Bond Cleavage by the Glycyl Radical Enzyme Choline Trimethylamine-Lyase.
Cell Chem Biol, 23, 2016
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5FAW
 | | T502A mutant of choline TMA-lyase | | Descriptor: | CHOLINE ION, Choline trimethylamine-lyase, MALONATE ION, ... | | Authors: | Funk, M.A, Drennan, C.L. | | Deposit date: | 2015-12-12 | | Release date: | 2016-09-28 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.852 Å) | | Cite: | Molecular Basis of C-N Bond Cleavage by the Glycyl Radical Enzyme Choline Trimethylamine-Lyase.
Cell Chem Biol, 23, 2016
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5FAU
 | | wild-type choline TMA lyase in complex with choline | | Descriptor: | CHOLINE ION, Choline trimethylamine-lyase, GLYCEROL | | Authors: | Funk, M.A, Drennan, C.L. | | Deposit date: | 2015-12-12 | | Release date: | 2016-09-28 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Molecular Basis of C-N Bond Cleavage by the Glycyl Radical Enzyme Choline Trimethylamine-Lyase.
Cell Chem Biol, 23, 2016
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6XN6
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