1WQ1
| RAS-RASGAP COMPLEX | Descriptor: | ALUMINUM FLUORIDE, GUANOSINE-5'-DIPHOSPHATE, H-RAS, ... | Authors: | Scheffzek, K, Ahmadian, M.R, Kabsch, W, Wiesmueller, L, Lautwein, A, Schmitz, F, Wittinghofer, A. | Deposit date: | 1997-07-03 | Release date: | 1998-07-15 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants. Science, 277, 1997
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1NF1
| THE GAP RELATED DOMAIN OF NEUROFIBROMIN | Descriptor: | PROTEIN (NEUROFIBROMIN) | Authors: | Scheffzek, K, Ahmadian, M.R, Wiesmueller, L, Kabsch, W, Stege, P, Schmitz, F, Wittinghofer, A. | Deposit date: | 1998-07-08 | Release date: | 1999-07-20 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural analysis of the GAP-related domain from neurofibromin and its implications. EMBO J., 17, 1998
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1UKE
| UMP/CMP KINASE FROM SLIME MOLD | Descriptor: | MAGNESIUM ION, P1-(ADENOSINE-5'-P5-(URIDINE-5')PENTAPHOSPHATE, URIDYLMONOPHOSPHATE/CYTIDYLMONOPHOSPHATE KINASE | Authors: | Scheffzek, K, Kliche, W, Wiesmueller, L, Reinstein, J. | Deposit date: | 1998-01-07 | Release date: | 1998-04-29 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of the complex of UMP/CMP kinase from Dictyostelium discoideum and the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-uridyl) pentaphosphate (UP5A) and Mg2+ at 2.2 A: implications for water-mediated specificity. Biochemistry, 35, 1996
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1WER
| RAS-GTPASE-ACTIVATING DOMAIN OF HUMAN P120GAP | Descriptor: | P120GAP | Authors: | Scheffzek, K, Lautwein, A, Kabsch, W, Ahmadian, M.R, Wittinghofer, A. | Deposit date: | 1996-11-20 | Release date: | 1997-12-31 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal structure of the GTPase-activating domain of human p120GAP and implications for the interaction with Ras. Nature, 384, 1996
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1DS6
| CRYSTAL STRUCTURE OF A RAC-RHOGDI COMPLEX | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2, ... | Authors: | Scheffzek, K, Stephan, I, Jensen, O.N, Illenberger, D, Gierschik, P. | Deposit date: | 2000-01-07 | Release date: | 2000-07-12 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI. Nat.Struct.Biol., 7, 2000
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1K8R
| Crystal structure of Ras-Bry2RBD complex | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Protein kinase byr2, ... | Authors: | Scheffzek, K, Gruenewald, P, Wohlgemuth, S, Kabsch, W, Tu, H, Wigler, M, Wittinghofer, A, Herrmann, C. | Deposit date: | 2001-10-25 | Release date: | 2002-03-13 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The Ras-Byr2RBD complex: structural basis for Ras effector recognition in yeast. Structure, 9, 2001
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6EHR
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6EHP
| The crystal structure of the human LAMTOR complex | Descriptor: | CHLORIDE ION, Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, ... | Authors: | Scheffzek, K, Naschberger, A. | Deposit date: | 2017-09-14 | Release date: | 2017-10-04 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling. Science, 358, 2017
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1CLU
| H-RAS COMPLEXED WITH DIAMINOBENZOPHENONE-BETA,GAMMA-IMIDO-GTP | Descriptor: | 3-AMINOBENZOPHENONE-4-YL-AMINOHYDROXYPHOSPHINYLAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION, TRANSFORMING PROTEIN P21/H-RAS-1 | Authors: | Ahmadian, M.R, Zor, T, Vogt, D, Kabsch, W, Selinger, Z, Wittinghofer, A, Scheffzek, K. | Deposit date: | 1999-05-03 | Release date: | 1999-05-28 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Guanosine triphosphatase stimulation of oncogenic Ras mutants. Proc.Natl.Acad.Sci.USA, 96, 1999
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2HRO
| Structure of the full-lenght Enzyme I of the PTS system from Staphylococcus carnosus | Descriptor: | Phosphoenolpyruvate-protein phosphotransferase, SULFATE ION | Authors: | Marquez, J.A, Reinelt, S, Koch, B, Engelman, R, Hengstenberg, W, Scheffzek, K. | Deposit date: | 2006-07-20 | Release date: | 2006-09-19 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of the full-length enzyme I of the phosphoenolpyruvate-dependent sugar phosphotransferase system J.Biol.Chem., 281, 2006
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3DXB
| Structure of the UHM domain of Puf60 fused to thioredoxin | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, thioredoxin N-terminally fused to Puf60(UHM) | Authors: | Corsini, L, Hothorn, M, Scheffzek, K, Stier, G, Sattler, M. | Deposit date: | 2008-07-24 | Release date: | 2008-10-28 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Dimerization and Protein Binding Specificity of the U2AF Homology Motif of the Splicing Factor Puf60. J.Biol.Chem., 284, 2009
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7R03
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7R04
| Neurofibromin in open conformation | Descriptor: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Isoform I of Neurofibromin | Authors: | Chaker-Margot, M, Scheffzek, K, Maier, T. | Deposit date: | 2022-02-01 | Release date: | 2022-03-30 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural basis of activation of the tumor suppressor protein neurofibromin. Mol.Cell, 82, 2022
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1RVD
| H-RAS COMPLEXED WITH DIAMINOBENZOPHENONE-BETA,GAMMA-IMIDO-GTP | Descriptor: | 3-AMINOBENZOPHENONE-4-YL-AMINOHYDROXYPHOSPHINYLAMINOPHOSPHONIC ACID-GUANYLATE ESTER, MAGNESIUM ION, TRANSFORMING PROTEIN P21/H-RAS-1 | Authors: | Ahmadian, M.R, Zor, T, Vogt, D, Kabsch, W, Selinger, Z, Wittinghofer, A, Scheffzek, K. | Deposit date: | 1999-05-03 | Release date: | 1999-05-28 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Guanosine triphosphatase stimulation of oncogenic Ras mutants. Proc.Natl.Acad.Sci.USA, 96, 1999
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3IIF
| Crystal structure of the macro domain of human histone macroH2A1.1 in complex with ADP-ribose (form B) | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, Core histone macro-H2A.1, Isoform 1 | Authors: | Hothorn, M, Bortfeld, M, Ladurner, A.G, Scheffzek, K. | Deposit date: | 2009-07-31 | Release date: | 2009-08-18 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation. Nat.Struct.Mol.Biol., 16, 2009
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3IPR
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3IID
| Crystal structure of the macro domain of human histone macroH2A1.1 in complex with ADP-ribose (form A) | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, Core histone macro-H2A.1, Isoform 1, ... | Authors: | Hothorn, M, Bortfeld, M, Ladurner, A.G, Scheffzek, K. | Deposit date: | 2009-07-31 | Release date: | 2009-08-18 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation. Nat.Struct.Mol.Biol., 16, 2009
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3P7Z
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3PEG
| Crystal structure of Neurofibromins Sec14-PH module containing a patient derived duplication (TD) | Descriptor: | (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, MAGNESIUM ION, Neurofibromin, ... | Authors: | Welti, S, Kuen, S, D'Angelo, I, Scheffzek, K. | Deposit date: | 2010-10-26 | Release date: | 2010-12-08 | Last modified: | 2019-07-17 | Method: | X-RAY DIFFRACTION (2.524 Å) | Cite: | Structural and biochemical consequences of NF1 associated nontruncating mutations in the Sec14-PH module of neurofibromin. Hum.Mutat., 32, 2011
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3PG7
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1HCI
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1GZS
| CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE GEF DOMAIN OF THE SALMONELLA TYPHIMURIUM SOPE TOXIN AND HUMAN Cdc42 | Descriptor: | GTP-BINDING PROTEIN, SOPE, SULFATE ION | Authors: | Buchwald, G, Friebel, A, Galan, J.E, Hardt, W.D, Wittinghofer, A, Scheffzek, K. | Deposit date: | 2002-06-05 | Release date: | 2002-09-12 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural Basis for the Reversible Activation of a Rho Protein by the Bacterial Toxin Sope Embo J., 21, 2002
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2XQR
| Crystal structure of plant cell wall invertase in complex with a specific protein inhibitor | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | Authors: | Hothorn, M, Van den Ende, W, Lammens, W, Rybin, V, Scheffzek, K. | Deposit date: | 2010-09-07 | Release date: | 2010-10-06 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.58 Å) | Cite: | Structural Insights Into the Ph-Controlled Targeting of Plant Cell-Wall Invertase by a Specific Inhibitor Protein. Proc.Natl.Acad.Sci.USA, 107, 2010
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4AEC
| Crystal Structure of the Arabidopsis thaliana O-Acetyl-Serine-(Thiol)- Lyase C | Descriptor: | ACETATE ION, CYSTEINE SYNTHASE, MITOCHONDRIAL, ... | Authors: | Feldman-Salit, A, Wirtz, M, Lenherr, E.D, Throm, C, Hothorn, M, Scheffzek, K, Hell, R, Wade, R.C. | Deposit date: | 2012-01-09 | Release date: | 2012-02-22 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Allosterically Gated Enzyme Dynamics in the Cysteine Synthase Complex Regulate Cysteine Biosynthesis in Arabidopsis Thaliana. Structure, 20, 2012
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2PK2
| Cyclin box structure of the P-TEFb subunit Cyclin T1 derived from a fusion complex with EIAV Tat | Descriptor: | Cyclin-T1, Protein Tat | Authors: | Anand, K, Schulte, A, Fujinaga, K, Scheffzek, K, Geyer, M. | Deposit date: | 2007-04-17 | Release date: | 2007-07-03 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.67 Å) | Cite: | Cyclin Box Structure of the P-TEFb Subunit Cyclin T1 Derived from a Fusion Complex with EIAV Tat. J.Mol.Biol., 370, 2007
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