3P7Z

Crystal structure of the Neurofibromin Sec14-PH module containing the patient derived mutation I1584V

Summary for 3P7Z

• Entry DOI: 10.2210/pdb3p7z/pdb
• Related: 2e2x
• Descriptor: Neurofibromin, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, SODIUM ION, ... (5 entities in total)
• Functional Keywords: sec14 homolgy domain, pleckstrin homology domain, binding of glycerophospholipids, glycerophospholipids, cytoplasmatic, lipid binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 65095.25

Authors

Welti, S.,Scheffzek, K. (deposition date: 2010-10-13, release date: 2010-12-08, Last modification date: 2019-07-17)

• Primary citation: Welti, S.,Kuhn, S.,D'Angelo, I.,Brugger, B.,Kaufmann, D.,Scheffzek, K.; Structural and biochemical consequences of NF1 associated nontruncating mutations in the Sec14-PH module of neurofibromin.; Hum.Mutat., 32:191-197, 2011; PubMed: 21089070; DOI: 10.1002/humu.21405

Experimental method

X-RAY DIFFRACTION (2.65 Å)