3P7Z
Crystal structure of the Neurofibromin Sec14-PH module containing the patient derived mutation I1584V
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Neurofibromin | polymer | 276 | 31640.2 | 2 | UniProt (P21359) Pfam (PF13716) Pfam (PF21877) | Homo sapiens (human) | Neurofibromatosis-related protein NF-1, Neurofibromin truncated |
| 2 | C, E (A, B) | (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE | non-polymer | 720.0 | 2 | Chemie (PEV) | |||
| 3 | D (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 4 | F, G (B) | PYROPHOSPHATE 2- | non-polymer | 176.0 | 2 | Chemie (POP) | |||
| 5 | H, I (A, B) | water | water | 18.0 | 166 | Chemie (HOH) |
Sequence modifications
A, B: 1545 - 1816 (UniProt: P21359)
| PDB | External Database | Details |
|---|---|---|
| Gly 1541 | - | expression tag |
| Ala 1542 | - | expression tag |
| Met 1543 | - | expression tag |
| Gly 1544 | - | expression tag |
| Val 1584 | Ile 1605 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 63280.3 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1814.9 | |
| All* | Total formula weight | 65095.3 |
