3SCJ
 
 | | Crystal structure of spike protein receptor-binding domain from a predicted SARS coronavirus civet strain complexed with human receptor ACE2 | | Descriptor: | Angiotensin-converting enzyme 2, CHLORIDE ION, Spike glycoprotein, ... | | Authors: | Wu, K, Peng, G, Wilken, M, Geraghty, R, Li, F. | | Deposit date: | 2011-06-07 | | Release date: | 2012-02-08 | | Last modified: | 2020-09-16 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Mechanisms of host receptor adaptation by severe acute respiratory syndrome coronavirus.
J.Biol.Chem., 287, 2012
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5Y1U
 | | Crystal structure of RBBP4 bound to AEBP2 RRK motif | | Descriptor: | Histone-binding protein RBBP4, SULFATE ION, Zinc finger protein AEBP2 | | Authors: | Sun, A, Li, F, Wu, J, Shi, Y. | | Deposit date: | 2017-07-21 | | Release date: | 2018-04-18 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.141 Å) | | Cite: | Structural and biochemical insights into human zinc finger protein AEBP2 reveals interactions with RBBP4
Protein Cell, 2017
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8J23
 | | Cryo-EM structure of FFAR2 complex in apo state | | Descriptor: | Free fatty acid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Tai, L, Li, F, Sun, X, Tang, W, Wang, J. | | Deposit date: | 2023-04-14 | | Release date: | 2024-04-17 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Molecular recognition and activation mechanism of short chain fatty acid receptors FFAR2 and FFAR3
To Be Published
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5YYZ
 | | Crystal structure of the MEK1 FHA domain in complex with the HOP1 pThr318 peptide. | | Descriptor: | Meiosis-specific protein HOP1, Meiosis-specific serine/threonine-protein kinase MEK1 | | Authors: | Xie, C, Li, F, Jiang, Y, Wu, J, Shi, Y. | | Deposit date: | 2017-12-11 | | Release date: | 2018-10-17 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.798 Å) | | Cite: | Structural insights into the recognition of phosphorylated Hop1 by Mek1
Acta Crystallogr D Struct Biol, 74, 2018
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5Z4D
 | | Structure of Tailor in complex with AGUU RNA | | Descriptor: | RNA (5'-R(*AP*GP*UP*U)-3'), Terminal uridylyltransferase Tailor | | Authors: | Cheng, L, Li, F, Jiang, Y, Yu, H, Xie, C, Shi, Y, Gong, Q. | | Deposit date: | 2018-01-11 | | Release date: | 2018-10-31 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.803 Å) | | Cite: | Structural insights into a unique preference for 3' terminal guanine of mirtron in Drosophila TUTase tailor.
Nucleic Acids Res., 47, 2019
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5Z4M
 | | Structure of TailorD343A with bound UTP and Mg | | Descriptor: | MAGNESIUM ION, Terminal uridylyltransferase Tailor, URIDINE 5'-TRIPHOSPHATE | | Authors: | Cheng, L, Li, F, Jiang, Y, Yu, H, Xie, C, Shi, Y, Gong, Q. | | Deposit date: | 2018-01-11 | | Release date: | 2018-10-31 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.74 Å) | | Cite: | Structural insights into a unique preference for 3' terminal guanine of mirtron in Drosophila TUTase tailor.
Nucleic Acids Res., 47, 2019
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5Z4C
 | | Crystal structure of Tailor | | Descriptor: | Terminal uridylyltransferase Tailor | | Authors: | Cheng, L, Li, F, Jiang, Y, Yu, H, Xie, C, Shi, Y, Gong, Q. | | Deposit date: | 2018-01-10 | | Release date: | 2018-10-31 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Structural insights into a unique preference for 3' terminal guanine of mirtron in Drosophila TUTase tailor.
Nucleic Acids Res., 47, 2019
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5WWW
 | | Crystal structure of the KH1 domain of human RNA-binding E3 ubiquitin-protein ligase MEX-3C complex with RNA | | Descriptor: | RNA (5'-R(*GP*UP*UP*UP*AP*G)-3'), RNA-binding E3 ubiquitin-protein ligase MEX3C | | Authors: | Yang, L, Wang, C, Li, F, Gong, Q. | | Deposit date: | 2017-01-05 | | Release date: | 2017-08-23 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.798 Å) | | Cite: | The human RNA-binding protein and E3 ligase MEX-3C binds the MEX-3-recognition element (MRE) motif with high affinity
J. Biol. Chem., 292, 2017
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5WWZ
 | | Crystal structure of the KH2 domain of human RNA-binding E3 ubiquitin-protein ligase MEX-3C | | Descriptor: | RNA-binding E3 ubiquitin-protein ligase MEX3C, SULFATE ION | | Authors: | Yang, L, Wang, C, Li, F, Gong, Q. | | Deposit date: | 2017-01-05 | | Release date: | 2017-08-23 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | The human RNA-binding protein and E3 ligase MEX-3C binds the MEX-3-recognition element (MRE) motif with high affinity
J. Biol. Chem., 292, 2017
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5WWX
 | | Crystal structure of the KH2 domain of human RNA-binding E3 ubiquitin-protein ligase MEX-3C complex with RNA | | Descriptor: | NICKEL (II) ION, RNA (5'-R(P*AP*GP*AP*GP*U)-3'), RNA-binding E3 ubiquitin-protein ligase MEX3C | | Authors: | Yang, L, Wang, C, Li, F, Gong, Q. | | Deposit date: | 2017-01-05 | | Release date: | 2017-08-23 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The human RNA-binding protein and E3 ligase MEX-3C binds the MEX-3-recognition element (MRE) motif with high affinity
J. Biol. Chem., 292, 2017
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8HKD
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5Z4J
 | | Structure of Tailor in complex with U4 RNA | | Descriptor: | RNA (5'-R(*UP*UP*UP*U)-3'), Terminal uridylyltransferase Tailor | | Authors: | Cheng, L, Li, F, Jiang, Y, Yu, H, Xie, C, Shi, Y, Gong, Q. | | Deposit date: | 2018-01-11 | | Release date: | 2018-10-31 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | Structural insights into a unique preference for 3' terminal guanine of mirtron in Drosophila TUTase tailor.
Nucleic Acids Res., 47, 2019
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5Z4A
 | | Structure of Tailor in complex with AGU RNA | | Descriptor: | RNA (5'-R(*AP*GP*U)-3'), Terminal uridylyltransferase Tailor | | Authors: | Cheng, L, Li, F, Jiang, Y, Yu, H, Xie, C, Shi, Y, Gong, Q. | | Deposit date: | 2018-01-10 | | Release date: | 2018-10-31 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.637 Å) | | Cite: | Structural insights into a unique preference for 3' terminal guanine of mirtron in Drosophila TUTase tailor.
Nucleic Acids Res., 47, 2019
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5YYX
 | | Crystal Structure of the MEK1 FHA domain | | Descriptor: | Meiosis-specific serine/threonine-protein kinase MEK1 | | Authors: | Xie, C, Li, F, Jiang, Y, Wu, J, Shi, Y. | | Deposit date: | 2017-12-11 | | Release date: | 2018-10-10 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.684 Å) | | Cite: | Structural insights into the recognition of phosphorylated Hop1 by Mek1
Acta Crystallogr D Struct Biol, 74, 2018
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6AAX
 | | Crystal structure of TFB1M and h45 with SAM in homo sapiens | | Descriptor: | DI(HYDROXYETHYL)ETHER, Dimethyladenosine transferase 1, mitochondrial, ... | | Authors: | Liu, X, Shen, S, Wu, P, Li, F, Gong, Q, Wu, J, Zhang, H, Shi, Y. | | Deposit date: | 2018-07-19 | | Release date: | 2019-06-05 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.994 Å) | | Cite: | Structural insights into dimethylation of 12S rRNA by TFB1M: indispensable role in translation of mitochondrial genes and mitochondrial function.
Nucleic Acids Res., 47, 2019
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7VCU
 | | Human p97 double hexamer conformer I with D1-ATPgammaS and D2-ADP bound | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | | Authors: | Gao, H, Li, F, Shi, Z, Li, Y, Yu, H. | | Deposit date: | 2021-09-04 | | Release date: | 2022-03-02 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.15 Å) | | Cite: | Cryo-EM structures of human p97 double hexamer capture potentiated ATPase-competent state.
Cell Discov, 8, 2022
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7VCT
 | | Human p97 single hexamer conformer III with D1-ATPgammaS and D2-ADP bound | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | | Authors: | Gao, H, Li, F, Shi, Z, Li, Y, Yu, H. | | Deposit date: | 2021-09-04 | | Release date: | 2022-03-02 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.21 Å) | | Cite: | Cryo-EM structures of human p97 double hexamer capture potentiated ATPase-competent state.
Cell Discov, 8, 2022
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7VCX
 | | Human p97 single hexamer conformer II with ATPgammaS bound | | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase | | Authors: | Gao, H, Li, F, Shi, Z, Li, Y, Yu, H. | | Deposit date: | 2021-09-04 | | Release date: | 2022-03-02 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.24 Å) | | Cite: | Cryo-EM structures of human p97 double hexamer capture potentiated ATPase-competent state.
Cell Discov, 8, 2022
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7VCS
 | | Human p97 double hexamer conformer II with ATPgammaS bound | | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase | | Authors: | Gao, H, Li, F, Shi, Z, Li, Y, Yu, H. | | Deposit date: | 2021-09-03 | | Release date: | 2022-03-02 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.32 Å) | | Cite: | Cryo-EM structures of human p97 double hexamer capture potentiated ATPase-competent state.
Cell Discov, 8, 2022
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7VCV
 | | Human p97 single hexamer conformer I with ATPgammaS bound | | Descriptor: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Transitional endoplasmic reticulum ATPase | | Authors: | Gao, H, Li, F, Shi, Z, Li, Y, Yu, H. | | Deposit date: | 2021-09-04 | | Release date: | 2022-03-02 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.21 Å) | | Cite: | Cryo-EM structures of human p97 double hexamer capture potentiated ATPase-competent state.
Cell Discov, 8, 2022
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7XA3
 | | Cryo-EM structure of the CCL2 bound CCR2-Gi complex | | Descriptor: | C-C motif chemokine 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Shao, Z, Tan, Y, Shen, Q, Yao, B, Hou, L, Qin, J, Xu, P, Mao, C, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Chen, Z, Jiang, Y, Xu, H.E, Ying, S, Ma, H, Zhang, Y, Shen, H. | | Deposit date: | 2022-03-17 | | Release date: | 2022-08-24 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3.
Cell Discov, 8, 2022
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7X9Y
 | | Cryo-EM structure of the apo CCR3-Gi complex | | Descriptor: | C-C chemokine receptor type 3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Shao, Z, Tan, Y, Shen, Q, Yao, B, Hou, L, Qin, J, Xu, P, Mao, C, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Chen, Z, Jiang, Y, Xu, H.E, Ying, S, Ma, H, Zhang, Y, Shen, H. | | Deposit date: | 2022-03-16 | | Release date: | 2022-08-24 | | Last modified: | 2024-06-26 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3.
Cell Discov, 8, 2022
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7VLA
 | | Cryo-EM structure of the CCL15(27-92) bound CCR1-Gi complex | | Descriptor: | C-C chemokine receptor type 1, CCL15(27-92), CHOLESTEROL, ... | | Authors: | Shao, Z, Shen, Q, Mao, C, Yao, B, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Ma, H, Chen, Z, Xu, H.E, Ying, S, Zhang, Y, Shen, H. | | Deposit date: | 2021-10-02 | | Release date: | 2022-03-23 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1.
Nat.Chem.Biol., 18, 2022
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7VL8
 | | Cryo-EM structure of the Apo CCR1-Gi complex | | Descriptor: | C-C chemokine receptor type 1, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Shao, Z, Shen, Q, Mao, C, Yao, B, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Ma, H, Chen, Z, Xu, H.E, Ying, S, Zhang, Y, Shen, H. | | Deposit date: | 2021-10-02 | | Release date: | 2022-03-23 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1.
Nat.Chem.Biol., 18, 2022
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7VL9
 | | Cryo-EM structure of the CCL15(26-92) bound CCR1-Gi complex | | Descriptor: | C-C chemokine receptor type 1, CCL15(26-92), CHOLESTEROL, ... | | Authors: | Shao, Z, Shen, Q, Mao, C, Yao, B, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Ma, H, Chen, Z, Xu, H.E, Ying, S, Zhang, Y, Shen, H. | | Deposit date: | 2021-10-02 | | Release date: | 2022-03-23 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Identification and mechanism of G protein-biased ligands for chemokine receptor CCR1.
Nat.Chem.Biol., 18, 2022
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