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8J5T
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BU of 8j5t by Molmil
Cryo-EM structure of Mycobacterium tuberculosis OppABCD in the catalytic intermediate state
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, IRON/SULFUR CLUSTER, MAGNESIUM ION, ...
Authors:Yang, X, Hu, T, Zhang, B, Rao, Z.
Deposit date:2023-04-24
Release date:2024-04-03
Last modified:2024-07-31
Method:ELECTRON MICROSCOPY (2.98 Å)
Cite:An oligopeptide permease, OppABCD, requires an iron-sulfur cluster domain for functionality.
Nat.Struct.Mol.Biol., 31, 2024
8J5Q
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BU of 8j5q by Molmil
Cryo-EM structure of Mycobacterium tuberculosis OppABCD in the pre-translocation state
Descriptor: Endogenous oligopeptide, IRON/SULFUR CLUSTER, Putative peptide transport permease protein Rv1282c, ...
Authors:Yang, X, Hu, T, Zhang, B, Rao, Z.
Deposit date:2023-04-24
Release date:2024-04-03
Last modified:2024-07-31
Method:ELECTRON MICROSCOPY (3.25 Å)
Cite:An oligopeptide permease, OppABCD, requires an iron-sulfur cluster domain for functionality.
Nat.Struct.Mol.Biol., 31, 2024
6VZB
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BU of 6vzb by Molmil
Crystal structure of cytochrome P450 NasF5053 S284A-V288A mutant variant from Streptomyces sp. NRRL F-5053 in the cyclo-L-Trp-L-Pro-bound state
Descriptor: (3S,8aS)-3-(1H-indol-3-ylmethyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione, PROTOPORPHYRIN IX CONTAINING FE, SODIUM ION, ...
Authors:Luo, Z, Jia, X, Sun, C, Qu, X, Kobe, B.
Deposit date:2020-02-28
Release date:2020-11-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Molecular basis of regio- and stereo-specificity in biosynthesis of bacterial heterodimeric diketopiperazines.
Nat Commun, 11, 2020
6VZA
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BU of 6vza by Molmil
Crystal structure of cytochrome P450 NasF5053 Q65I-A86G mutant variant from Streptomyces sp. NRRL F-5053 in the cyclo-L-Trp-L-Pro-bound state
Descriptor: (3S,8aS)-3-(1H-indol-3-ylmethyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione, CALCIUM ION, CHLORIDE ION, ...
Authors:Luo, Z, Jia, X, Sun, C, Qu, X, Kobe, B.
Deposit date:2020-02-28
Release date:2020-11-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Molecular basis of regio- and stereo-specificity in biosynthesis of bacterial heterodimeric diketopiperazines.
Nat Commun, 11, 2020
6VXV
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BU of 6vxv by Molmil
Crystal structure of cyclo-L-Trp-L-Pro-bound cytochrome P450 NasF5053 from Streptomyces sp. NRRL F-5053
Descriptor: (3S,8aS)-3-(1H-indol-3-ylmethyl)hexahydropyrrolo[1,2-a]pyrazine-1,4-dione, CALCIUM ION, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Luo, Z, Jia, X, Sun, C, Qu, X, Kobe, B.
Deposit date:2020-02-24
Release date:2020-11-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Molecular basis of regio- and stereo-specificity in biosynthesis of bacterial heterodimeric diketopiperazines.
Nat Commun, 11, 2020
6W0S
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BU of 6w0s by Molmil
Crystal structure of substrate free cytochrome P450 NasF5053 from Streptomyces sp. NRRL F-5053
Descriptor: BROMIDE ION, CHLORIDE ION, GLYCEROL, ...
Authors:Luo, Z, Jia, X, Sun, C, Qu, X, Kobe, B.
Deposit date:2020-03-02
Release date:2020-11-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Molecular basis of regio- and stereo-specificity in biosynthesis of bacterial heterodimeric diketopiperazines.
Nat Commun, 11, 2020
5C15
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BU of 5c15 by Molmil
K428A mutant nuclease domain of the large terminase subunit gp2 of bacterial virus Sf6 with Manganese
Descriptor: Gene 2 protein, MANGANESE (II) ION
Authors:Zhao, H, Tang, L.
Deposit date:2015-06-12
Release date:2015-10-21
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Two distinct modes of metal ion binding in the nuclease active site of a viral DNA-packaging terminase: insight into the two-metal-ion catalytic mechanism.
Nucleic Acids Res., 43, 2015
5C12
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BU of 5c12 by Molmil
Nuclease domain of the large terminase subunit gp2 of bacterial virus Sf6
Descriptor: Gene 2 protein, MAGNESIUM ION
Authors:Zhao, H, Tang, L.
Deposit date:2015-06-12
Release date:2015-10-21
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.517 Å)
Cite:Two distinct modes of metal ion binding in the nuclease active site of a viral DNA-packaging terminase: insight into the two-metal-ion catalytic mechanism.
Nucleic Acids Res., 43, 2015
8IS2
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BU of 8is2 by Molmil
Crystal structure of a polyketide aromatase/cyclase Abx(+)D from Actinomycetes sp. MA7150.
Descriptor: Cyclase
Authors:Luo, S, Chen, X.
Deposit date:2023-03-20
Release date:2024-02-28
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:An unusual aromatase/cyclase programs the formation of the phenyldimethylanthrone framework in anthrabenzoxocinones and fasamycin.
Proc.Natl.Acad.Sci.USA, 121, 2024
6TYY
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BU of 6tyy by Molmil
Hedgehog autoprocessing mutant D46H
Descriptor: Protein hedgehog
Authors:Li, H, Li, Z, Wang, C, Callahan, B.P.
Deposit date:2019-08-09
Release date:2019-11-20
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:General Base Swap Preserves Activity and Expands Substrate Tolerance in Hedgehog Autoprocessing.
J.Am.Chem.Soc., 141, 2019
5C2F
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BU of 5c2f by Molmil
K428A mutant nuclease domain of the large terminase subunit gp2 of bacterial virus Sf6 with Manganese and beta-thujaplicinol
Descriptor: 2,7-dihydroxy-4-(propan-2-yl)cyclohepta-2,4,6-trien-1-one, Gene 2 protein, MANGANESE (II) ION
Authors:Zhao, H, Tang, L.
Deposit date:2015-06-15
Release date:2015-10-21
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Two distinct modes of metal ion binding in the nuclease active site of a viral DNA-packaging terminase: insight into the two-metal-ion catalytic mechanism.
Nucleic Acids Res., 43, 2015
5C10
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BU of 5c10 by Molmil
Nuclease domain of the large terminase subunit gp2 of bacterial virus Sf6
Descriptor: Gene 2 protein
Authors:Zhao, H, Tang, L.
Deposit date:2015-06-12
Release date:2015-10-21
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Two distinct modes of metal ion binding in the nuclease active site of a viral DNA-packaging terminase: insight into the two-metal-ion catalytic mechanism.
Nucleic Acids Res., 43, 2015
5C2D
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BU of 5c2d by Molmil
K428A mutant gp2c of large terminase subunit from bacteriophage sf6 with calcium
Descriptor: CALCIUM ION, Gene 2 protein
Authors:Zhao, H, Tang, L.
Deposit date:2015-06-15
Release date:2015-10-21
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Two distinct modes of metal ion binding in the nuclease active site of a viral DNA-packaging terminase: insight into the two-metal-ion catalytic mechanism.
Nucleic Acids Res., 43, 2015
5CET
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BU of 5cet by Molmil
Crystal structure of Rv2837c
Descriptor: Bifunctional oligoribonuclease and PAP phosphatase NrnA, MANGANESE (II) ION
Authors:Wang, F, He, Q, Zhu, D, Liu, S, Gu, L.
Deposit date:2015-07-07
Release date:2015-12-23
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and Biochemical Insight into the Mechanism of Rv2837c from Mycobacterium tuberculosis as a c-di-NMP Phosphodiesterase
J.Biol.Chem., 291, 2016
5WAL
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BU of 5wal by Molmil
Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model
Descriptor: N-[2-(2,6-dichlorophenyl)-1H-imidazo[4,5-c]pyridin-4-yl]cyclopropanecarboxamide, Non-receptor tyrosine-protein kinase TYK2
Authors:Ultsch, M.H, Magnuson, S.
Deposit date:2017-06-26
Release date:2017-09-06
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model.
Bioorg. Med. Chem. Lett., 27, 2017
5WHG
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BU of 5whg by Molmil
Vms1 mitochondrial localization core
Descriptor: Protein VMS1, ZINC ION
Authors:Fredrickson, E.K, Schubert, H.L, Rutter, J, Hill, C.P.
Deposit date:2017-07-17
Release date:2017-11-15
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Sterol Oxidation Mediates Stress-Responsive Vms1 Translocation to Mitochondria.
Mol. Cell, 68, 2017
5V6G
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BU of 5v6g by Molmil
Crystal structure of Influenza A virus Matrix Protein M1(NLS-88R)
Descriptor: Matrix protein 1
Authors:Musayev, F.N, Safo, M.K, Desai, U.R, Xie, H, Mosier, P.D, Chiang, M.-J.
Deposit date:2017-03-16
Release date:2017-04-12
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication.
Emerg Microbes Infect, 6, 2017
4H6H
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BU of 4h6h by Molmil
Crystal Structure of Staphylococcal Complement Inhibitor SCIN-B(4-85)
Descriptor: Fibrinogen-binding protein
Authors:Garcia, B.L, Geisbrecht, B.V.
Deposit date:2012-09-19
Release date:2012-12-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.5024 Å)
Cite:A Structurally Dynamic N-terminal Helix Is a Key Functional Determinant in Staphylococcal Complement Inhibitor (SCIN) Proteins.
J.Biol.Chem., 288, 2013
4H6I
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BU of 4h6i by Molmil
Crystal Structure of Staphylococcal Complement Inhibitor SCIN-B
Descriptor: Fibrinogen-binding protein
Authors:Garcia, B.L, Geisbrecht, B.V.
Deposit date:2012-09-19
Release date:2012-12-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.091 Å)
Cite:A Structurally Dynamic N-terminal Helix Is a Key Functional Determinant in Staphylococcal Complement Inhibitor (SCIN) Proteins.
J.Biol.Chem., 288, 2013
5V8A
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BU of 5v8a by Molmil
Crystal structure of Influenza A virus matrix protein M1 (NLS-88R, pH 7.3)
Descriptor: Matrix protein 1
Authors:Musayev, F.N, Safo, M.K, Desai, U.R, Xie, H, Mosier, P.D, Zhou, Q, Chiang, M.-J, Kosikova, M.
Deposit date:2017-03-21
Release date:2017-04-19
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3 Å)
Cite:Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication.
Emerg Microbes Infect, 6, 2017
5V7B
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BU of 5v7b by Molmil
Crystal structure of Influenza A virus matrix protein M1 (NLS-88E)
Descriptor: Matrix protein 1
Authors:Musayev, F.N, Safo, M.K, Desai, U.R, Xie, H, Mosier, P.D, Chiang, M.-J.
Deposit date:2017-03-20
Release date:2017-04-12
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication.
Emerg Microbes Infect, 6, 2017
3HR5
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BU of 3hr5 by Molmil
M1prime peptide from IgE bound by humanized antibody 47H4 Fab
Descriptor: Fab h47H4 heavy chain, Fab h47H4 light chain, GLYCEROL, ...
Authors:Eigenbrot, C.W, Ultsch, M.H.
Deposit date:2009-06-08
Release date:2010-05-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice.
J.Clin.Invest., 120, 2010
5V7S
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BU of 5v7s by Molmil
Crystal structure of Influenza A virus matrix protein M1 (NLS-88E, pH 6.2)
Descriptor: Matrix protein 1, PHOSPHATE ION
Authors:Musayev, F.N, Safo, M.K, Althufairi, B, Desai, U.R, Xie, H, Mosier, P.D, Chiang, M.-J, Zhou, Q.
Deposit date:2017-03-20
Release date:2017-04-12
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication.
Emerg Microbes Infect, 6, 2017
5WEV
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BU of 5wev by Molmil
Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model
Descriptor: N-[2-(2,6-dichlorophenyl)-1H-imidazo[4,5-c]pyridin-4-yl]cyclopropanecarboxamide, Tyrosine-protein kinase JAK2
Authors:Ultsch, M.H, Magnuson, S.
Deposit date:2017-07-10
Release date:2017-09-06
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.854 Å)
Cite:Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model.
Bioorg. Med. Chem. Lett., 27, 2017
7CGS
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BU of 7cgs by Molmil
Crystal endo-deglycosylated hydroxynitrile lyase isozyme 5 mutant L343F from Prunus communis
Descriptor: (R)-mandelonitrile lyase, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zheng, Y.C, Li, F.L.
Deposit date:2020-07-02
Release date:2021-04-21
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:A High-Throughput Screening Method for the Directed Evolution of Hydroxynitrile Lyase towards Cyanohydrin Synthesis.
Chembiochem, 22, 2021

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數據於2024-10-16公開中

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