4XO9
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![BU of 4xo9 by Molmil](/molmil-images/mine/4xo9) | Crystal structure of a FimH*DsG complex from E.coli K12 in space group C2 | Descriptor: | Minor component of type 1 fimbriae, Protein FimH | Authors: | Jakob, R.P, Eras, J, Glockshuber, R, Maier, T. | Deposit date: | 2015-01-16 | Release date: | 2016-01-27 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.14 Å) | Cite: | Catch-bond mechanism of the bacterial adhesin FimH. Nat Commun, 7, 2016
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3PHT
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3HWN
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![BU of 3hwn by Molmil](/molmil-images/mine/3hwn) | CATHEPSIN L with AZ13010160 | Descriptor: | Cathepsin L1, Nalpha-[(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)carbonyl]-N-[(2E)-2-iminoethyl]-3-{5-[(Z)-iminomethyl]-1,3,4-oxadiazol-2-yl}-L-phenylalaninamide | Authors: | Kenny, P, Morley, A. | Deposit date: | 2009-06-18 | Release date: | 2009-09-15 | Last modified: | 2021-10-13 | Method: | X-RAY DIFFRACTION (2.33 Å) | Cite: | Design of selective Cathepsin inhibitors Bioorg.Med.Chem.Lett., 19, 2009
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4J7I
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![BU of 4j7i by Molmil](/molmil-images/mine/4j7i) | SET7/9Y335F in complex with TAF10 peptide and AdoHcy | Descriptor: | Histone-lysine N-methyltransferase SETD7, S-ADENOSYL-L-HOMOCYSTEINE, Transcription initiation factor TFIID subunit 10 | Authors: | Horowitz, S, Trievel, R.C. | Deposit date: | 2013-02-13 | Release date: | 2014-01-08 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.56 Å) | Cite: | Conservation and functional importance of carbon-oxygen hydrogen bonding in AdoMet-dependent methyltransferases. J.Am.Chem.Soc., 135, 2013
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4J83
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![BU of 4j83 by Molmil](/molmil-images/mine/4j83) | SET7/9 in complex with TAF10K189A peptide and AdoMet | Descriptor: | Histone-lysine N-methyltransferase SETD7, S-ADENOSYLMETHIONINE, Transcription initiation factor TFIID subunit 10 | Authors: | Horowitz, S, Nimtz, J.S, Trievel, R.C. | Deposit date: | 2013-02-14 | Release date: | 2014-01-08 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Conservation and functional importance of carbon-oxygen hydrogen bonding in AdoMet-dependent methyltransferases. J.Am.Chem.Soc., 135, 2013
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4PZV
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![BU of 4pzv by Molmil](/molmil-images/mine/4pzv) | Crystal structure of Francisella tularensis HPPK-DHPS in complex with bisubstrate analog HPPK inhibitor J1D | Descriptor: | 1,2-ETHANEDIOL, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase/dihydropteroate synthase, 5'-{[2-({N-[(2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)carbonyl]glycyl}amino)ethyl]sulfonyl}-5'-deoxyadenosine | Authors: | Shaw, G.X, Shi, G, Ji, X. | Deposit date: | 2014-03-31 | Release date: | 2014-07-16 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.704 Å) | Cite: | Structural enzymology and inhibition of the bi-functional folate pathway enzyme HPPK-DHPS from the biowarfare agent Francisella tularensis. Febs J., 281, 2014
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2ZBK
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![BU of 2zbk by Molmil](/molmil-images/mine/2zbk) | Crystal structure of an intact type II DNA topoisomerase: insights into DNA transfer mechanisms | Descriptor: | RADICICOL, Type 2 DNA topoisomerase 6 subunit B, Type II DNA topoisomerase VI subunit A | Authors: | Graille, M, Cladiere, L, Durand, D, Lecointe, F, Forterre, P, van Tilbeurgh, H, Paris-Sud Yeast Structural Genomics (YSG) | Deposit date: | 2007-10-22 | Release date: | 2008-02-12 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.56 Å) | Cite: | Crystal Structure of an Intact Type II DNA Topoisomerase: Insights into DNA Transfer Mechanisms Structure, 16, 2008
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5GAP
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![BU of 5gap by Molmil](/molmil-images/mine/5gap) | Body region of the U4/U6.U5 tri-snRNP | Descriptor: | 13 kDa ribonucleoprotein-associated protein, Pre-mRNA-processing factor 31, Pre-mRNA-splicing factor 6, ... | Authors: | Nguyen, T.H.D, Galej, W.P, Oubridge, C, Bai, X.C, Newman, A, Scheres, S, Nagai, K. | Deposit date: | 2015-12-15 | Release date: | 2016-01-27 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 angstrom resolution. Nature, 530, 2016
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3MTF
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![BU of 3mtf by Molmil](/molmil-images/mine/3mtf) | Crystal structure of the ACVR1 kinase in complex with a 2-aminopyridine inhibitor | Descriptor: | 1,2-ETHANEDIOL, 3-[6-amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol, Activin receptor type-1, ... | Authors: | Chaikuad, A, Sanvitale, C, Cooper, C, Mahajan, P, Daga, N, Petrie, K, Alfano, I, Canning, P, Krojer, T, Vollmar, M, Knapp, S, von Delft, F, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A, Structural Genomics Consortium (SGC) | Deposit date: | 2010-04-30 | Release date: | 2010-06-23 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | A new class of small molecule inhibitor of BMP signaling. Plos One, 8, 2013
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4LIQ
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![BU of 4liq by Molmil](/molmil-images/mine/4liq) | Structure of the extracellular domain of human CSF-1 receptor in complex with the Fab fragment of RG7155 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab fragment RG7155 heavy chain, Fab fragment RG7155 light chain, ... | Authors: | Benz, J, Gorr, I.H, Hertenberger, H, Ries, C.H. | Deposit date: | 2013-07-03 | Release date: | 2014-06-18 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy Cancer Cell, 25, 2014
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4M84
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4ONW
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![BU of 4onw by Molmil](/molmil-images/mine/4onw) | Crystal structure of the catalytic domain of DapE protein from V.cholerea | Descriptor: | 1,2-ETHANEDIOL, 1,4-BUTANEDIOL, ACETATE ION, ... | Authors: | Nocek, B, Makowska-Grzyska, M, Jedrzejczak, R, Gu, M, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2014-01-29 | Release date: | 2014-04-23 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | The Dimerization Domain in DapE Enzymes Is required for Catalysis. Plos One, 9, 2014
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4OP4
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![BU of 4op4 by Molmil](/molmil-images/mine/4op4) | Crystal structure of the catalytic domain of DapE protein from V.cholerea in the Zn bound form | Descriptor: | 1,2-ETHANEDIOL, 1,4-BUTANEDIOL, GLYCEROL, ... | Authors: | Nocek, B, Makowska-Grzyska, M, Jedrzejczak, R, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2014-02-04 | Release date: | 2014-04-23 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.651 Å) | Cite: | The Dimerization Domain in DapE Enzymes Is required for Catalysis. Plos One, 9, 2014
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1G63
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![BU of 1g63 by Molmil](/molmil-images/mine/1g63) | PEPTIDYL-CYSTEINE DECARBOXYLASE EPID | Descriptor: | EPIDERMIN MODIFYING ENZYME EPID, FLAVIN MONONUCLEOTIDE | Authors: | Blaesse, M, Kupke, T, Huber, R, Steinbac, S. | Deposit date: | 2000-11-03 | Release date: | 2001-05-03 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of the peptidyl-cysteine decarboxylase EpiD complexed with a pentapeptide substrate. EMBO J., 19, 2000
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3J2T
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![BU of 3j2t by Molmil](/molmil-images/mine/3j2t) | An improved model of the human apoptosome | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Apoptotic protease-activating factor 1, Cytochrome c, ... | Authors: | Yuan, S, Topf, M, Akey, C.W. | Deposit date: | 2012-12-23 | Release date: | 2013-04-10 | Last modified: | 2018-07-18 | Method: | ELECTRON MICROSCOPY (9.5 Å) | Cite: | Changes in apaf-1 conformation that drive apoptosome assembly. Biochemistry, 52, 2013
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6I57
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3NST
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![BU of 3nst by Molmil](/molmil-images/mine/3nst) | Crystal Structure of Salicylate 1,2-dioxygenase G106A mutant from Pseudoaminobacter salicylatoxidans | Descriptor: | FE (II) ION, GLYCEROL, Gentisate 1,2-dioxygenase | Authors: | Ferraroni, M, Briganti, F, Matera, I. | Deposit date: | 2010-07-02 | Release date: | 2011-07-13 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The salicylate 1,2-dioxygenase as a model for a conventional gentisate 1,2-dioxygenase: crystal structures of the G106A mutant and its adducts with gentisate and salicylate. FEBS J., 280, 2013
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3NVD
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![BU of 3nvd by Molmil](/molmil-images/mine/3nvd) | Structure of YBBD in complex with pugnac | Descriptor: | ACETATE ION, O-(2-ACETAMIDO-2-DEOXY D-GLUCOPYRANOSYLIDENE) AMINO-N-PHENYLCARBAMATE, SODIUM ION, ... | Authors: | Diederichs, K. | Deposit date: | 2010-07-08 | Release date: | 2010-08-04 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.836 Å) | Cite: | Structural and kinetic analysis of Bacillus subtilis N-acetylglucosaminidase reveals a unique Asp-His dyad mechanism J.Biol.Chem., 285, 2010
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2ZEX
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![BU of 2zex by Molmil](/molmil-images/mine/2zex) | Family 16 carbohydrate binding module | Descriptor: | CALCIUM ION, S-layer associated multidomain endoglucanase, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose | Authors: | Bae, B, Nair, S.K. | Deposit date: | 2007-12-18 | Release date: | 2008-03-04 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Molecular Basis for the Selectivity and Specificity of Ligand Recognition by the Family 16 Carbohydrate-binding Modules from Thermoanaerobacterium polysaccharolyticum ManA J.Biol.Chem., 283, 2008
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2ZEZ
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![BU of 2zez by Molmil](/molmil-images/mine/2zez) | Family 16 Carbohydrate Binding Module-2 | Descriptor: | CALCIUM ION, S-layer associated multidomain endoglucanase | Authors: | Bae, B, Nair, S.K. | Deposit date: | 2007-12-18 | Release date: | 2008-03-25 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Molecular Basis for the Selectivity and Specificity of Ligand Recognition by the Family 16 Carbohydrate-binding Modules from Thermoanaerobacterium polysaccharolyticum ManA J.Biol.Chem., 283, 2008
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3T92
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![BU of 3t92 by Molmil](/molmil-images/mine/3t92) | Crystal structure of the Taz2:C/EBPepsilon-TAD chimera protein | Descriptor: | 3,3',3''-phosphanetriyltripropanoic acid, ACETONE, HISTONE ACETYLTRANSFERASE P300 TAZ2-CCAAT/ENHANCER-BINDING PROTEIN EPSILON, ... | Authors: | Bhaumik, P, Maria, M. | Deposit date: | 2011-08-02 | Release date: | 2012-08-08 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural insights into interactions of C/EBP transcriptional activators with the Taz2 domain of p300. Acta Crystallogr. D Biol. Crystallogr., 70, 2014
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5I2V
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1RTF
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5EGW
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5EF4
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![BU of 5ef4 by Molmil](/molmil-images/mine/5ef4) | 2.05 A crystal structure of the Amb a 11 cysteine protease, a major ragweed pollen allergen, in its proform | Descriptor: | Cysteine protease, GLYCEROL | Authors: | Briozzo, P, Kopecny, D, Savko, M. | Deposit date: | 2015-10-23 | Release date: | 2016-04-27 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structural and Functional Characterization of the Major Allergen Amb a 11 from Short Ragweed Pollen. J.Biol.Chem., 291, 2016
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