3HWN
CATHEPSIN L with AZ13010160
Summary for 3HWN
Entry DOI | 10.2210/pdb3hwn/pdb |
Descriptor | Cathepsin L1, Nalpha-[(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)carbonyl]-N-[(2E)-2-iminoethyl]-3-{5-[(Z)-iminomethyl]-1,3,4-oxadiazol-2-yl}-L-phenylalaninamide (3 entities in total) |
Functional Keywords | cathepsin l, drug design, disulfide bond, glycoprotein, hydrolase, lysosome, protease, thiol protease, zymogen |
Biological source | Homo sapiens (human) |
Cellular location | Lysosome: P07711 |
Total number of polymer chains | 4 |
Total formula weight | 116573.32 |
Authors | Kenny, P.,Morley, A. (deposition date: 2009-06-18, release date: 2009-09-15, Last modification date: 2021-10-13) |
Primary citation | Bethel, P.A.,Gerhardt, S.,Jones, E.V.,Kenny, P.W.,Karoutchi, G.I.,Morley, A.D.,Oldham, K.,Rankine, N.,Augustin, M.,Krapp, S.,Simader, H.,Steinbacher, S. Design of selective Cathepsin inhibitors Bioorg.Med.Chem.Lett., 19:4622-4625, 2009 Cited by PubMed: 19616430DOI: 10.1016/j.bmcl.2009.06.090 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.33 Å) |
Structure validation
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