5I2V

NMR structure of a new G-quadruplex forming sequence within the KRAS proto-oncogene promoter region

Summary for 5I2V

• Entry DOI: 10.2210/pdb5i2v/pdb
• NMR Information: BMRB: 30012
• Descriptor: DNA (5'-D(*AP*GP*GP*GP*CP*GP*GP*TP*GP*TP*GP*GP*GP*AP*AP*TP*AP*GP*GP*GP*AP*A)-3'), POTASSIUM ION (2 entities in total)
• Functional Keywords: g-quadruplex, kras, proto-oncogene, cancer target, dna
• Biological source: Homo sapiens
• Total number of polymer chains: 1
• Total formula weight: 7064.71

Authors

Salgado, G.F.,Kerkour, A.,Mergny, J.-L. (deposition date: 2016-02-09, release date: 2016-03-16, Last modification date: 2023-06-14)

• Primary citation: Kerkour, A.,Marquevielle, J.,Ivashchenko, S.,Yatsunyk, L.A.,Mergny, J.L.,Salgado, G.F.; High-resolution three-dimensional NMR structure of the KRAS proto-oncogene promoter reveals key features of a G-quadruplex involved in transcriptional regulation.; J. Biol. Chem., 292:8082-8091, 2017; PubMed: 28330874; DOI: 10.1074/jbc.M117.781906

Experimental method

SOLUTION NMR