3DUH
 
 | | Structure of Interleukin-23 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 subunit beta, Interleukin-23 subunit alpha | | Authors: | Lupardus, P.J, Garcia, K.C. | | Deposit date: | 2008-07-17 | | Release date: | 2008-08-19 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12.
J.Mol.Biol., 382, 2008
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3GCD
 | | Structure of the V. cholerae RTX cysteine protease domain in complex with an aza-Leucine peptide inhibitor | | Descriptor: | INOSITOL HEXAKISPHOSPHATE, RTX toxin RtxA, SODIUM ION, ... | | Authors: | Lupardus, P.J, Garcia, K.C, Shen, A, Bogyo, M. | | Deposit date: | 2009-02-21 | | Release date: | 2009-05-26 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Mechanistic and structural insights into the proteolytic activation of Vibrio cholerae MARTX toxin.
Nat.Chem.Biol., 5, 2009
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4Y5Y
 | | Diabody 330 complex with EpoR | | Descriptor: | Erythropoietin receptor, GLYCEROL, diabody 330 VH domain, ... | | Authors: | Moraga, I, Guo, F, Ozkan, E, Jude, K.M, Garcia, K.C. | | Deposit date: | 2015-02-12 | | Release date: | 2015-03-18 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands.
Cell, 160, 2015
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3E2H
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3E0G
 | | Structure of the Leukemia Inhibitory Factor Receptor (LIF-R) domains D1-D5 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Leukemia inhibitory factor receptor, ... | | Authors: | Lupardus, P.J, Garcia, K.C. | | Deposit date: | 2008-07-31 | | Release date: | 2008-09-23 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structural organization of a full-length gp130/LIF-R cytokine receptor transmembrane complex.
Mol.Cell, 31, 2008
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4YQX
 | | Mouse IL-2 Bound to JES6-1 scFv Fragment | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-2, JES6-1 VH domain, ... | | Authors: | Spangler, J.B, Luca, V.C, Jude, K.M, Garcia, K.C. | | Deposit date: | 2015-03-13 | | Release date: | 2015-07-01 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.826 Å) | | Cite: | Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms.
Immunity, 42, 2015
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4YUE
 | | Mouse IL-2 Bound to S4B6 Fab Fragment | | Descriptor: | GLYCEROL, Interleukin-2, S4B6 Fab heavy chain, ... | | Authors: | Spangler, J.B, Jude, K.M, Garcia, K.C. | | Deposit date: | 2015-03-18 | | Release date: | 2015-07-01 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.194 Å) | | Cite: | Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms.
Immunity, 42, 2015
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3EEB
 | | Structure of the V. cholerae RTX cysteine protease domain | | Descriptor: | INOSITOL HEXAKISPHOSPHATE, RTX toxin RtxA, SODIUM ION | | Authors: | Lupardus, P.J, Shen, A, Bogyo, M, Garcia, K.C. | | Deposit date: | 2008-09-04 | | Release date: | 2008-10-21 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Small molecule-induced allosteric activation of the Vibrio cholerae RTX cysteine protease domain
Science, 322, 2008
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7N3T
 | | TrkA ECD complex with designed miniprotein ligand | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Jude, K.M, Cao, L, Garcia, K.C. | | Deposit date: | 2021-06-01 | | Release date: | 2022-04-20 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | Design of protein-binding proteins from the target structure alone.
Nature, 605, 2022
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7N2Q
 | | AS4.3-YEIH-HLA*B27 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, AS4.3 T cell receptor alpha chain, AS4.3 T cell receptor beta chain, ... | | Authors: | Yang, X, Jude, K.M, Garcia, K.C. | | Deposit date: | 2021-05-29 | | Release date: | 2022-12-07 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides.
Nature, 612, 2022
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7N2S
 | | AS3.1-PRPF3-HLA*B27 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, GLYCEROL, ... | | Authors: | Yang, X, Jude, K.M, Garcia, K.C. | | Deposit date: | 2021-05-29 | | Release date: | 2022-12-07 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.37 Å) | | Cite: | Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides.
Nature, 612, 2022
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7N2R
 | | AS4.3-PRPF3-HLA*B27 | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, AS4.3 T cell receptor alpha chain, ... | | Authors: | Yang, X, Jude, K.M, Garcia, K.C. | | Deposit date: | 2021-05-29 | | Release date: | 2022-12-07 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.28 Å) | | Cite: | Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides.
Nature, 612, 2022
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7N2N
 | | TCR-antigen complex AS4.2-PRPF3-HLA*B27 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, GLYCEROL, ... | | Authors: | Yang, X, Jude, K.M, Garcia, K.C. | | Deposit date: | 2021-05-29 | | Release date: | 2022-12-07 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides.
Nature, 612, 2022
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2PXY
 | | Crystal structures of immune receptor complexes | | Descriptor: | H-2 class II histocompatibility antigen, A-U alpha chain, A-U beta chain, ... | | Authors: | Feng, D, Bond, C.J, Ely, L.K, Garcia, K.C. | | Deposit date: | 2007-05-14 | | Release date: | 2007-10-09 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.23 Å) | | Cite: | Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'.
Nat.Immunol., 8, 2007
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4OFY
 | | Crystal Structure of the Complex of SYG-1 D1-D2 and SYG-2 D1-D4 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ETHYL MERCURY ION, ... | | Authors: | Ozkan, E, Garcia, K.C. | | Deposit date: | 2014-01-15 | | Release date: | 2014-02-19 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Extracellular Architecture of the SYG-1/SYG-2 Adhesion Complex Instructs Synaptogenesis.
Cell(Cambridge,Mass.), 156, 2014
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4OF0
 | | Crystal Structure of SYG-1 D1-D2, refolded | | Descriptor: | Protein SYG-1, isoform b | | Authors: | Ozkan, E, Garcia, K.C. | | Deposit date: | 2014-01-14 | | Release date: | 2014-02-19 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Extracellular Architecture of the SYG-1/SYG-2 Adhesion Complex Instructs Synaptogenesis.
Cell(Cambridge,Mass.), 156, 2014
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4OFK
 | | Crystal Structure of SYG-2 D4 | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | | Authors: | Ozkan, E, Borek, D, Otwinowski, Z, Garcia, K.C. | | Deposit date: | 2014-01-15 | | Release date: | 2014-02-19 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.802 Å) | | Cite: | Extracellular Architecture of the SYG-1/SYG-2 Adhesion Complex Instructs Synaptogenesis.
Cell(Cambridge,Mass.), 156, 2014
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4GAI
 | | Crystal structure of EBI-005, a chimera of human IL-1beta and IL-1Ra | | Descriptor: | EBI-005 | | Authors: | Hou, J, Townson, S.A, Kovalchin, J.T, Masci, A, Kiner, O, Shu, Y, King, B, Thomas, C, Garcia, K.C, Furfine, E.S, Barnes, T.M. | | Deposit date: | 2012-07-25 | | Release date: | 2013-02-20 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.49 Å) | | Cite: | Design of a superior cytokine antagonist for topical ophthalmic use.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4OF7
 | | Crystal Structure of SYG-1 D1, Crystal Form 2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Protein SYG-1, isoform b, ... | | Authors: | Ozkan, E, Garcia, K.C. | | Deposit date: | 2014-01-14 | | Release date: | 2014-02-19 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Extracellular Architecture of the SYG-1/SYG-2 Adhesion Complex Instructs Synaptogenesis.
Cell(Cambridge,Mass.), 156, 2014
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4GS7
 | | Structure of the Interleukin-15 quaternary complex | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Ring, A.M, Ozkan, E, Feng, D, Garcia, K.C. | | Deposit date: | 2012-08-27 | | Release date: | 2012-11-07 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15.
Nat.Immunol., 13, 2012
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4OF6
 | | Crystal Structure of SYG-1 D1, Crystal form 1 | | Descriptor: | 1,2-ETHANEDIOL, Protein SYG-1, isoform b, ... | | Authors: | Ozkan, E, Garcia, K.C. | | Deposit date: | 2014-01-14 | | Release date: | 2014-02-19 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.696 Å) | | Cite: | Extracellular Architecture of the SYG-1/SYG-2 Adhesion Complex Instructs Synaptogenesis.
Cell(Cambridge,Mass.), 156, 2014
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4P2Q
 | | Crystal structure of the 5cc7 TCR in complex with 5c2/I-Ek | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5c2 peptide, 5cc7 T-cell receptor alpha chain, ... | | Authors: | Birnbaum, M.E, Ozkan, E, Garcia, K.C. | | Deposit date: | 2014-03-04 | | Release date: | 2014-05-21 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Deconstructing the Peptide-MHC Specificity of T Cell Recognition.
Cell, 157, 2014
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4GAF
 | | Crystal structure of EBI-005, a chimera of human IL-1beta and IL-1Ra, bound to human Interleukin-1 receptor type 1 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, EBI-005, Interleukin-1 receptor type 1, ... | | Authors: | Hou, J, Townson, S.A, Kovalchin, J.T, Masci, A, Kiner, O, Shu, Y, King, B, Thomas, C, Garcia, K.C, Furfine, E.S, Barnes, T.M. | | Deposit date: | 2012-07-25 | | Release date: | 2013-02-20 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Design of a superior cytokine antagonist for topical ophthalmic use.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4P2R
 | | Crystal structure of the 5cc7 TCR in complex with 5c1/I-Ek | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5c1 peptide, 5cc7 T-cell receptor alpha chain, ... | | Authors: | Birnbaum, M.E, Ozkan, E, Garcia, K.C. | | Deposit date: | 2014-03-04 | | Release date: | 2014-05-21 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (3.295 Å) | | Cite: | Deconstructing the Peptide-MHC Specificity of T Cell Recognition.
Cell, 157, 2014
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4P2O
 | | Crystal structure of the 2B4 TCR in complex with 2A/I-Ek | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2A peptide, 2B4 T-cell receptor alpha chain, ... | | Authors: | Birnbaum, M.E, Ozkan, E, Garcia, K.C. | | Deposit date: | 2014-03-04 | | Release date: | 2014-05-21 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.603 Å) | | Cite: | Deconstructing the Peptide-MHC Specificity of T Cell Recognition.
Cell, 157, 2014
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