7RQE
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![BU of 7rqe by Molmil](/molmil-images/mine/7rqe) | Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site deacylated tRNA analog CACCA, P-site MAI-tripeptidyl-tRNA analog ACCA-IAM, and chloramphenicol at 2.40A resolution | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ... | Authors: | Syroegin, E.A, Flemmich, L, Klepacki, D, Vazquez-Laslop, N, Micura, R, Polikanov, Y.S. | Deposit date: | 2021-08-06 | Release date: | 2022-01-26 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis for the context-specific action of the classic peptidyl transferase inhibitor chloramphenicol. Nat.Struct.Mol.Biol., 29, 2022
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6JQL
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![BU of 6jql by Molmil](/molmil-images/mine/6jql) | Structure of PaaZ, a bifunctional enzyme | Descriptor: | Bifunctional protein PaaZ | Authors: | Gakher, L, Vinothkumar, K.R, Katagihallimath, N, Sowdhamini, R, Sathyanarayanan, N, Cannone, G. | Deposit date: | 2019-03-31 | Release date: | 2019-09-11 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Molecular basis for metabolite channeling in a ring opening enzyme of the phenylacetate degradation pathway. Nat Commun, 10, 2019
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5BK7
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![BU of 5bk7 by Molmil](/molmil-images/mine/5bk7) | The structure of MppP E15A mutant soaked with the substrate L-arginine | Descriptor: | (E)-N~2~-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-arginine, PLP-Dependent L-Arginine Hydroxylase MppP | Authors: | Han, L, Silvaggi, N.R. | Deposit date: | 2018-01-27 | Release date: | 2018-09-05 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.196 Å) | Cite: | Streptomyces wadayamensis MppP is a PLP-Dependent Oxidase, Not an Oxygenase. Biochemistry, 57, 2018
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7RQA
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![BU of 7rqa by Molmil](/molmil-images/mine/7rqa) | Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site MTI-tripeptidyl-tRNA analog ACCA-ITM at 2.40A resolution | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, ... | Authors: | Syroegin, E.A, Flemmich, L, Klepacki, D, Vazquez-Laslop, N, Micura, R, Polikanov, Y.S. | Deposit date: | 2021-08-06 | Release date: | 2022-01-26 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis for the context-specific action of the classic peptidyl transferase inhibitor chloramphenicol. Nat.Struct.Mol.Biol., 29, 2022
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5ZJP
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5Z9J
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![BU of 5z9j by Molmil](/molmil-images/mine/5z9j) | Identification of the functions of unusual cytochrome p450-like monooxygenases involved in microbial secondary metablism | Descriptor: | PROTOPORPHYRIN IX CONTAINING FE, Putative P450-like enzyme, TRIS(HYDROXYETHYL)AMINOMETHANE | Authors: | Lu, M, Lin, L, Zhang, C, Chen, Y. | Deposit date: | 2018-02-03 | Release date: | 2019-02-06 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Riboflavin Is Directly Involved in the N-Dealkylation Catalyzed by Bacterial Cytochrome P450 Monooxygenases. Chembiochem, 2020
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1XNV
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![BU of 1xnv by Molmil](/molmil-images/mine/1xnv) | Acyl-CoA Carboxylase Beta Subunit from S. coelicolor (PccB), apo form #1 | Descriptor: | propionyl-CoA carboxylase complex B subunit | Authors: | Diacovich, L, Mitchell, D.L, Pham, H, Gago, G, Melgar, M.M, Khosla, C, Gramajo, H, Tsai, S.-C. | Deposit date: | 2004-10-05 | Release date: | 2004-11-09 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal Structure of the beta-Subunit of Acyl-CoA Carboxylase: Structure-Based Engineering of Substrate Specificity Biochemistry, 43, 2004
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5ZAM
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![BU of 5zam by Molmil](/molmil-images/mine/5zam) | Cryo-EM structure of human Dicer and its complexes with a pre-miRNA substrate | Descriptor: | Endoribonuclease Dicer, RISC-loading complex subunit TARBP2, RNA (73-mer) | Authors: | Liu, Z, Wang, J, Cheng, H, Ke, X, Sun, L, Zhang, Q.C, Wang, H.-W. | Deposit date: | 2018-02-07 | Release date: | 2018-05-09 | Last modified: | 2020-08-05 | Method: | ELECTRON MICROSCOPY (5.7 Å) | Cite: | Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate. Cell, 173, 2018
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1XL8
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![BU of 1xl8 by Molmil](/molmil-images/mine/1xl8) | Crystal structure of mouse carnitine octanoyltransferase in complex with octanoylcarnitine | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CARNITINE, OCTANOYLCARNITINE, ... | Authors: | Jogl, G, Hsiao, Y.S, Tong, L. | Deposit date: | 2004-09-30 | Release date: | 2004-10-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of mouse carnitine octanoyltransferase and molecular determinants of substrate selectivity. J.Biol.Chem., 280, 2005
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5BMZ
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![BU of 5bmz by Molmil](/molmil-images/mine/5bmz) | Crystal Structure of Putative MarR Family Transcriptional Regulator HcaR from Acinetobacter sp. ADP complexed with 24mer DNA. | Descriptor: | DNA (5'-D(P*GP*AP*AP*TP*AP*TP*CP*AP*GP*TP*TP*AP*AP*AP*CP*TP*GP*AP*TP*AP*TP*TP*C)-3'), HcaR protein | Authors: | Kim, Y, Joachimiak, G, Biglow, L, Cobb, G, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2015-05-25 | Release date: | 2015-10-14 | Last modified: | 2020-01-01 | Method: | X-RAY DIFFRACTION (3.001 Å) | Cite: | Crystal Structure of Putative MarR Family Transcriptional Regulator HcaR from Acinetobacter sp. ADP complexed with 24mer DNA. To Be Published
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1MSZ
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![BU of 1msz by Molmil](/molmil-images/mine/1msz) | Solution structure of the R3H domain from human Smubp-2 | Descriptor: | DNA-binding protein SMUBP-2 | Authors: | Liepinsh, E, Leonchiks, A, Sharipo, A, Guignard, L, Otting, G. | Deposit date: | 2002-09-20 | Release date: | 2002-10-09 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the R3H domain from human Smubp-2 J.Mol.Biol., 326, 2003
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5M5Y
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![BU of 5m5y by Molmil](/molmil-images/mine/5m5y) | RNA Polymerase I elongation complex 2 | Descriptor: | DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... | Authors: | Tafur, L, Sadian, Y, Hoffmann, N.A, Jakobi, A.J, Wetzel, R, Hagen, W.J.H, Sachse, C, Muller, C.W. | Deposit date: | 2016-10-23 | Release date: | 2016-12-21 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Molecular Structures of Transcribing RNA Polymerase I. Mol. Cell, 64, 2016
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5MG9
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![BU of 5mg9 by Molmil](/molmil-images/mine/5mg9) | Putative Ancestral Mamba toxin 1 (AncTx1-W28R/I38S) | Descriptor: | 1,2-ETHANEDIOL, AncTx1-W28R/I38S, S-1,2-PROPANEDIOL, ... | Authors: | Stura, E.A, Tepshi, L, Blanchet, G, Mourier, G, Servent, D. | Deposit date: | 2016-11-21 | Release date: | 2017-05-03 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.801 Å) | Cite: | Ancestral protein resurrection and engineering opportunities of the mamba aminergic toxins. Sci Rep, 7, 2017
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1XMC
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![BU of 1xmc by Molmil](/molmil-images/mine/1xmc) | C323M mutant structure of mouse carnitine octanoyltransferase | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Peroxisomal carnitine O-octanoyltransferase | Authors: | Jogl, G, Hsiao, Y.S, Tong, L. | Deposit date: | 2004-10-01 | Release date: | 2004-10-19 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of mouse carnitine octanoyltransferase and molecular determinants of substrate selectivity. J.Biol.Chem., 280, 2005
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1XR0
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![BU of 1xr0 by Molmil](/molmil-images/mine/1xr0) | Structural Basis of SNT PTB Domain Interactions with Distinct Neurotrophic Receptors | Descriptor: | Basic fibroblast growth factor receptor 1, FGFR signalling adaptor SNT-1 | Authors: | Dhalluin, C, Yan, K.S, Plotnikova, O, Lee, K.W, Zeng, L, Kuti, M, Mujtaba, S, Goldfarb, M.P, Zhou, M.-M. | Deposit date: | 2004-10-13 | Release date: | 2004-11-02 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structural Basis of SNT PTB Domain Interactions with Distinct Neurotrophic Receptors Mol.Cell, 6, 2000
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5BQQ
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![BU of 5bqq by Molmil](/molmil-images/mine/5bqq) | Human insulin with intra-chain chemical crosslink between modified B27 and B30 | Descriptor: | CHLORIDE ION, Insulin, PHENOL, ... | Authors: | Brzozowski, A.M, Turkenburg, J.P, Jiracek, J, Zakova, L. | Deposit date: | 2015-05-29 | Release date: | 2016-02-03 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Rational steering of insulin binding specificity by intra-chain chemical crosslinking. Sci Rep, 6, 2016
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5YW8
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1XO5
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![BU of 1xo5 by Molmil](/molmil-images/mine/1xo5) | Crystal structure of CIB1, an EF-hand, integrin and kinase-binding protein | Descriptor: | CALCIUM ION, Calcium and integrin-binding protein 1 | Authors: | Gentry, H.R, Singer, A.U, Betts, L, Yang, C, Ferrara, J.D, Parise, L.V, Sondek, J. | Deposit date: | 2004-10-05 | Release date: | 2004-12-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Structural and Biochemical Characterization of CIB1 Delineates a New Family of EF-hand-containing Proteins J.Biol.Chem., 280, 2005
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5MIV
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![BU of 5miv by Molmil](/molmil-images/mine/5miv) | G307E variant of murine Apoptosis Inducing Factor in complex with NAD+ | Descriptor: | Apoptosis-inducing factor 1, mitochondrial, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Sorrentino, L, Cossu, F, Aliverti, A, Milani, M, Mastrangelo, E. | Deposit date: | 2016-11-29 | Release date: | 2017-07-12 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural bases of the altered catalytic properties of a pathogenic variant of apoptosis inducing factor. Biochem. Biophys. Res. Commun., 490, 2017
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1N4I
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![BU of 1n4i by Molmil](/molmil-images/mine/1n4i) | Solution structure of spruce budworm antifreeze protein at 5 degrees celsius | Descriptor: | thermal hysteresis protein | Authors: | Graether, S.P, Gagne, S.M, Spyracopoulos, L, Jia, Z, Davies, P.L, Sykes, B.D. | Deposit date: | 2002-10-31 | Release date: | 2003-04-08 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Spruce Budworm Antifreeze Protein: Changes in Structure and Dynamics at Low Temperature J.Mol.Biol., 327, 2003
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5MKJ
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![BU of 5mkj by Molmil](/molmil-images/mine/5mkj) | Crystal structure of the Retinoid X Receptor alpha in complex with synthetic honokiol derivative 9 and a fragment of the TIF2 co-activator. | Descriptor: | (~{E})-3-[4-oxidanyl-3-(5-prop-2-enyl-2-propoxy-phenyl)phenyl]prop-2-enoic acid, LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN-ASP, Retinoic acid receptor RXR-alpha | Authors: | Andrei, S.A, Brunsveld, L, Scheepstra, M, Ottmann, C. | Deposit date: | 2016-12-05 | Release date: | 2017-11-08 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization. ACS Chem Neurosci, 8, 2017
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5YWO
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![BU of 5ywo by Molmil](/molmil-images/mine/5ywo) | Structure of JEV-2F2 Fab complex | Descriptor: | 2F2 heavy chain, 2F2 light chain, JEV E protein, ... | Authors: | Qiu, X, Lei, Y.F, Yang, P, Gao, Q, Wang, N, Cao, L, Yuan, S, Wang, X, Xu, Z.K, Rao, Z. | Deposit date: | 2017-11-29 | Release date: | 2018-03-21 | Last modified: | 2018-09-12 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Structural basis for neutralization of Japanese encephalitis virus by two potent therapeutic antibodies Nat Microbiol, 3, 2018
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5BTE
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1XWK
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![BU of 1xwk by Molmil](/molmil-images/mine/1xwk) | 2.3 angstrom resolution crystal structure of human glutathione S-transferase M1A-1A complexed with glutathionyl-S-dinitrobenzene | Descriptor: | GLUTATHIONE S-(2,4 DINITROBENZENE), Glutathione S-transferase Mu 1 | Authors: | Patskovsky, Y, Patskovska, L, Almo, S.C, Listowsky, I. | Deposit date: | 2004-11-01 | Release date: | 2004-12-21 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Transition state model and mechanism of nucleophilic aromatic substitution reactions catalyzed by human glutathione S-transferase M1a-1a. Biochemistry, 45, 2006
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5Z1F
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![BU of 5z1f by Molmil](/molmil-images/mine/5z1f) | |