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7RDR
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BU of 7rdr by Molmil
Circular tandem repeat protein with novel repeat topology and enhanced subunit contact surfaces
Descriptor: Circular tendon repeat protein
Authors:Shen, B.W, Stoddard, B.L.
Deposit date:2021-07-10
Release date:2021-09-01
Last modified:2021-11-17
Method:ELECTRON MICROSCOPY (6.5 Å)
Cite:Design of functionalised circular tandem repeat proteins with longer repeat topologies and enhanced subunit contact surfaces.
Commun Biol, 4, 2021
4YY2
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BU of 4yy2 by Molmil
Computationally designed left-handed alpha/alpha toroid with 3 repeats in space group P212121
Descriptor: SODIUM ION, dTor_3x33L
Authors:Hallinan, J.P, Bradley, P, Stoddard, B.L.
Deposit date:2015-03-23
Release date:2015-12-16
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.854 Å)
Cite:Rational design of alpha-helical tandem repeat proteins with closed architectures.
Nature, 528, 2015
4YY5
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BU of 4yy5 by Molmil
Computationally designed left-handed alpha/alpha toroid with 3 repeats in space group P43212
Descriptor: dTor_3x33L
Authors:Hallinan, J.P, Bradley, P, Stoddard, B.L.
Deposit date:2015-03-23
Release date:2015-12-16
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Rational design of alpha-helical tandem repeat proteins with closed architectures.
Nature, 528, 2015
6TXZ
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BU of 6txz by Molmil
FAB PART OF M6903 IN COMPLEX WITH HUMAN TIM3
Descriptor: Fab H, Fab L, Hepatitis A virus cellular receptor 2
Authors:Musil, D, Sood, V.
Deposit date:2020-01-15
Release date:2020-04-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.06 Å)
Cite:Identification and characterization of M6903, an antagonistic anti-TIM-3 monoclonal antibody.
Oncoimmunology, 9, 2020
5T2O
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BU of 5t2o by Molmil
Engineered variant of I-OnuI meganuclease targeting the Anopheles AGAP011377 gene; harbors 53 point mutations relative to wild-type I-OnuI
Descriptor: CALCIUM ION, DNA (26-MER), I-OnuI_e-ag011377
Authors:Stoddard, B.L, Werther, R.
Deposit date:2016-08-23
Release date:2017-05-03
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Crystallographic analyses illustrate significant plasticity and efficient recoding of meganuclease target specificity.
Nucleic Acids Res., 45, 2017
5T2H
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BU of 5t2h by Molmil
Engineered variant of I-OnuI meganuclease targeting the Human TCRa gene; harbors 43 point mutations relative to wild-type I-OnuI
Descriptor: CALCIUM ION, DNA (26-MER), I-OnuI_e-hTCRa
Authors:Stoddard, B.L, Werther, R.
Deposit date:2016-08-23
Release date:2017-05-03
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.517 Å)
Cite:Crystallographic analyses illustrate significant plasticity and efficient recoding of meganuclease target specificity.
Nucleic Acids Res., 45, 2017
5T2N
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BU of 5t2n by Molmil
Engineered variant of I-OnuI meganuclease targeting the Anopheles AGAP007280 gene; harbors 38 point mutations relative to wild-type I-OnuI
Descriptor: CALCIUM ION, DNA (26-MER), I-OnuI_e-ag007820
Authors:Stoddard, B.L, Werther, R.
Deposit date:2016-08-23
Release date:2017-05-03
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.079 Å)
Cite:Crystallographic analyses illustrate significant plasticity and efficient recoding of meganuclease target specificity.
Nucleic Acids Res., 45, 2017
6UVW
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BU of 6uvw by Molmil
Engineered variant of I-OnuI meganuclease with improved thermostability
Descriptor: CALCIUM ION, DNA (27-MER), I-OnuI-e-Therm
Authors:Werther, R, Stoddard, B.L.
Deposit date:2019-11-04
Release date:2019-12-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.551 Å)
Cite:Optimization of Protein Thermostability and Exploitation of Recognition Behavior to Engineer Altered Protein-DNA Recognition.
Structure, 28, 2020
6UWK
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BU of 6uwk by Molmil
Engineered variant of I-OnuI meganuclease with improved stability and fully altered specificity targeting human chromosome 11 trans integration site
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, DNA (27-MER), ...
Authors:Werther, R, Stoddard, B.L.
Deposit date:2019-11-05
Release date:2019-12-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.533 Å)
Cite:Optimization of Protein Thermostability and Exploitation of Recognition Behavior to Engineer Altered Protein-DNA Recognition.
Structure, 28, 2020
6UWJ
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BU of 6uwj by Molmil
Intermediate engineered variant of I-OnuI meganuclease with improved thermostability and partially altered specificity
Descriptor: CALCIUM ION, DNA (27-MER), I-OnuI-e-Therm-hChr11v2
Authors:Werther, R, Stoddard, B.L.
Deposit date:2019-11-05
Release date:2019-12-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.852 Å)
Cite:Optimization of Protein Thermostability and Exploitation of Recognition Behavior to Engineer Altered Protein-DNA Recognition.
Structure, 28, 2020
6UWH
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BU of 6uwh by Molmil
Intermediate engineered variant of I-OnuI meganuclease with improved thermostability and partially altered specificity
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, DNA (26-MER), ...
Authors:Werther, R, Stoddard, B.L.
Deposit date:2019-11-05
Release date:2019-12-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.299 Å)
Cite:Optimization of Protein Thermostability and Exploitation of Recognition Behavior to Engineer Altered Protein-DNA Recognition.
Structure, 28, 2020
6UW0
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BU of 6uw0 by Molmil
Engineered variant of I-OnuI meganuclease with improved thermostability and fully altered specificity targeting cholera toxin A subunit
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, DNA (27-MER), ...
Authors:Werther, R, Stoddard, B.L.
Deposit date:2019-11-04
Release date:2019-12-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Optimization of Protein Thermostability and Exploitation of Recognition Behavior to Engineer Altered Protein-DNA Recognition.
Structure, 28, 2020
6UWG
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BU of 6uwg by Molmil
Engineered variant of I-OnuI meganuclease with improved thermostability and E178D mutation at catalytic site
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, DNA (26-MER), ...
Authors:Werther, R, Stoddard, B.L.
Deposit date:2019-11-05
Release date:2019-12-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Optimization of Protein Thermostability and Exploitation of Recognition Behavior to Engineer Altered Protein-DNA Recognition.
Structure, 28, 2020
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數據於2024-11-06公開中

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